A Case of Encephalitis Caused by Epstein-Barr Virus Infection
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
An 11-year-old girl was diagnosed with encephalitis due to Epstein-Barr virus(EBV). She was admitted to our hospital due to convulsion and decreased consciousness after several days of fever, sore throat and headache. Cerebrospinal fluid analysis showed lymphocyte-dominant pleocytosis and markedly elevated levels of protein. Magnetic resonance imaging(MRI) finding was normal, except for marked leptomeningeal enhancement. Even though she had signs and symptoms of infectious mononucleosis, EBV infection could not be considered as the underlying cause of the encephalitis until IgM for the viral capsid antigen of EBV had been detected in her blood. After treatment with acyclovir, a high dose of methylprednisolone and intravenous immunoglobulin, the neurological symptoms improved rapidly. She has not suffered from any neurological complications in the four months since being discharged. EBV infection should be considered as the main etiology in cases of childhood encephalitis, although there is no evidence of infectious mononucleosis existed.
Abstract
An 11-year-old girl was diagnosed with encephalitis due to Epstein-Barr virus(EBV). She was admitted to our hospital due to convulsion and decreased consciousness after several days of fever, sore throat and headache. Cerebrospinal fluid analysis showed lymphocyte-dominant pleocytosis and markedly elevated levels of protein. Magnetic resonance imaging(MRI) finding was normal, except for marked leptomeningeal enhancement. Even though she had signs and symptoms of infectious mononucleosis, EBV infection could not be considered as the underlying cause of the encephalitis until IgM for the viral capsid antigen of EBV had been detected in her blood. After treatment with acyclovir, a high dose of methylprednisolone and intravenous immunoglobulin, the neurological symptoms improved rapidly. She has not suffered from any neurological complications in the four months since being discharged. EBV infection should be considered as the main etiology in cases of childhood encephalitis, although there is no evidence of infectious mononucleosis existed.
참고문헌 (14)
- Bale JF Jr., "Human herpesviruses and neurological disorders of childhood", Semin Pediatr Neurol, 6, pp.278~287 (1999)
- Doja A., "Pediatric Epstein- barr virus-associated encephalitis: 10-year review", J Child Neurol, 21, pp.385~391 (2006)
- Domachowske JB., "Acute manifestations and neurologic sequelae of Epstein-Barr virus encephalitis in children", Pediatr Infect Dis J, 15, pp.871~875 (1996)
- Volpi A., "Epstein-Barr virus and human herpesvirus type 8 infections of the central nervous system", Herpes, 11(2), pp.120A~127A (2004)
- Jenson HB., "Epstein-Barr Virus in :Nelson Textbook of pediatrics", pp.1372~1376 (2007), W.B. Saunders Co
- Häusler M., "Neurological complications of acute and persistent Epstein- barr virus infection in paediatric patients", J Med Virol, 68, pp.253~263 (2002)
- Hoover SE., "Epstein-Barr virus in :Infections of the Central Nervous System", pp.175~183 (2004), Lippincott-Raven Publishers
- Booss J., "Viral Encephalitis in Humans" (2003), American Society for Microbiology
- Schnell RG., "Infectious mononucleosis: Neurologic and EEG findings", Medicine, 45, pp.51~63 (1966)
- James FB Jr., "Viral infections of the nervous system in :Pediatric neurology: principles & practice", pp.1609~1610 (2006), Mosby
- Baumgarten E., "Life-threatening infectious mononucleosis: Is it correlated with virus-induced T cell proliferation?", Clin Infect Dis, 19, pp.152~156 (1994)
- Sullivan JL., "Treatment of life-threatening Epstein-Barr virus infection with acyclovir", Am J Med, 73, pp.262~266 (1982)
- Fujimoto H., "Epstein-barr virus infections of the central nervous system", Intern Med, 42, pp.33~40 (2003)
- Grillo E., "Epstein-barr virus acute encephalomyelitis in a 13-year-old boy", Eur J Paediatr Neurol, 12, pp.417~420 (2008)