A Case of Acute Encephalopathy in Respiratory Syncytial Virus Sepsis Syndrome
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초록
Respiratory syncytial virus (RSV) is the most common and important etiologic agent of early childhood respiratory infections, resulting in significant morbidity and mortality. Extrapulmonary manifestations combined with respiratory symptoms are being reported more frequently in severe RSV infection, but the encephalopathy associated with this infection is not well recognized. RSV encephalopathy was present with impaired consciousness, cyanosis, sucking disorder preceding convulsive seizures. The authors describe the symptoms and outcomes of an 8monthold boy, who present with acute encephalopathy and had prematurity, bronchopulmonary dysplasia as comorbidities. The boy developed sepsis syndrome, characterized by hypotension, hepatic and renal dysfunctions, later found to be infected with RSV. He finally recovered after treatment with immumoglobulin and supportive care but required portable mechanical ventilation, nasogastric tube feeding, and anticonvulsant medication at discharge.
Abstract
Respiratory syncytial virus (RSV) is the most common and important etiologic agent of early childhood respiratory infections, resulting in significant morbidity and mortality. Extrapulmonary manifestations combined with respiratory symptoms are being reported more frequently in severe RSV infection, but the encephalopathy associated with this infection is not well recognized. RSV encephalopathy was present with impaired consciousness, cyanosis, sucking disorder preceding convulsive seizures. The authors describe the symptoms and outcomes of an 8monthold boy, who present with acute encephalopathy and had prematurity, bronchopulmonary dysplasia as comorbidities. The boy developed sepsis syndrome, characterized by hypotension, hepatic and renal dysfunctions, later found to be infected with RSV. He finally recovered after treatment with immumoglobulin and supportive care but required portable mechanical ventilation, nasogastric tube feeding, and anticonvulsant medication at discharge.
참고문헌 (16)
- Sweetman LL, "Neurologic complications associated with respiratory syncytial virus", Pediatr Neurol, 32, pp.307~310 (2005)
- Hall CB, "Clinical and epidemiologic features of respiratory syncytial virus", Curr Top Microbiol Immunol, 372, pp.39~57 (2013)
- Kho N, "Respiratory syncytial virus infection and neurologic abnormalities : retrospective cohort study", J Child Neurol, 19, pp.859~864 (2004)
- Kliegman R., "Nelson Textbook of Pediatrics", pp.1126~1129 (2011), Elsevier
- Willson DF, "Complications in infants hospitalized for bronchiolitis or respiratory syncytial virus pneumonia", J Pediatr, 143(5 Suppl), pp.S142~S149 (2003)
- Ng YT, "Encephalopathy associated with respiratory syncytial virus bronchiolitis", J Child Neurol, 16, pp.105~108 (2001)
- Inoue S, "Early infantile patients of RS viral bronchiolitis with afebrile convulsions", No to Hattatsu, 35, pp.347~349 (2003)
- Antonucci R, "Acute encephalopathy associated with respiratory syncytial virus infections in childhood. A literature review", Minerva Pediatr, 57, pp.137~142 (2005)
- 박수경, "극소 저체중 출생아에서 SynagisⓇ (palivizumab) 접종이 respiratory syncytial virus 감염으로 인한 재입원에 미치는 영향", Korean Journal of Pediatrics, 53(3), pp.358~363 (2010), 대한소아과학회
- Njoku DB, "Atypical extrapulmonary presentations of severe respiratory syncytial virus infection requiring intensive care", Clin Pediatr(Phila), 32, pp.455~460 (1993)
- Eisenhut M., "Extrapulmonary manifestations of severe respiratory syncytial virus infection - a systemic review", Crit Care, 10, pp.R107~ (2006)
- Ralston S, "Incidence of apnea in infants hospitalized with respiratory syncytial virus bronchiolitis : a systemic review", J Pediatr, 155, pp.728~733 (2009)
- Van Steensel-Moll HA, "Respiratory syncytial virus infections in children admitted to the intensive care unit", Pediatrie, 44, pp.583~588 (1989)
- Kawashima H, "Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations", J Infect Chemother, 18, pp.827~831 (2012)
- Park A, "Respiratory syncytial virus-related encephalitis : magnetic resonance imaging findings with diffuse-weighted study", Neuroradiology, 56, pp.163~168 (2014)
- Ichiyama T, "Serum and CSF levels of cytokines in acute encephalopathy following prolonged febrile seizures", Brain Dev, 30, pp.47~52 (2008)