중심장액맥락망막병증 환자에서 유리체내 베바시주맙 주입술의 단기효과
The Short-term Effect of Intravitreal Bevacizumab for Treatment of Central Serous Chorioretinopathy
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목적: 중심장액맥락망막병증 환자에서 유리체내 bevacizumab 주입술의 유용성에 대해 알아보고자 하였다. 대상과 방법: 3개월 이상 증상이 지속되어 bevacizumab 1.25 mg 유리체내 주입술을 시행한 42명의 중심장액맥락망막병증 환자에대해 후향적으로 연구하였다. 1개월째에 시행한 시력측정, 안저검사, 빛간섭단층촬영 결과로 시력변화 및 감각신경망막박리 호전여부를 조사하였다. 결과: 증상의 지속기간은 평균 3.9±2.31개월이었고, bevacizumab 유리체내 주입술 전의 평균 교정시력은 0.53±0.31이었다. 시술1개월 후 평균 교정시력은 0.72±0.29로 상승하였으며, 42안 중 32안(76.2%)에서 안저검사 및 빛간섭단층촬영상 감각신경망막박리가소멸되었다. 감각신경망막박리가 지속된 10안 중 5안에 대해 bevacizumab 유리체내 주입술을 다시 시행하였고, 재시행 1개월 후에3안에서 감각신경망막박리의 호전을 보였다. 재시행하지 않은 환자들은 1개월 후에도 감각신경망막박리가 모두 지속되었다. 결론: 유리체내 bevacizumab 주입술은 중심장액맥락망막병증의 호전에 단기적인 도움이 되는 것으로 생각된다.
Abstract
Purpose: To determine whether intravitreal bevacizumab is effective for the treatment of central serous chorioretinopathy. Methods: We retrospectively examined 42 eyes after intravitreal bevacizumab (1.25 mg) injection for central serous chorioretinopathy. After 1 month, improvement of vision and change in sensory retinal detachment were evaluated with a fundus examination and optical coherence tomography. Results: The mean duration of symptoms was 3.9±2.31 months. After intravitreal bevacizumab injection, mean best corrected visual acuity improved from 0.53±0.31 to 0.72±0.29 at 1 month. In addition, neurosensory retinal detachment disappeared in 32patients (76.2%). Five patients among ten who did not show improvement of neurosensory retinal detachment underwent reinjection of bevaczumab, and three of those reinjected showed the resolution of neurosensory retinal detachment at another 1 month. No improvement was seen among the patients who did not undergo reinjection. Conclusions: Intravitreal bevacizumab injection appears to have a short-term benefit for the treatment of central serous chorioretinopathy.
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