본문 바로가기
KERD
논문KCI 등재

쯔쯔가무시병에서 발생한 전포도막염 1예

Case of Tsutsugamushi Disease With Anterior Uveitis

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류안과학

초록

목적: 전포도막염과 상안검에 가피를 동반한 쯔쯔가무시병 환자 1예를 보고하고자 한다. 증례요약: 56세 여자환자가 우안의 통증과 점진적인 시력저하를 주소로 내원하였다. 전신검사상 우측 목부위의 림프절이 촉진되었고 이마와 윗눈꺼풀 부위에 가피가 관찰되었다. 세극등검사상에서 우안결막충혈과 상공막혈관의 확장이 보였으며 심한 전방 염증이 관찰 되었다. 안저검사상 특이소견은 없었다. 진단을 위해 내과에 혈액검사를 의뢰하였으며 쯔쯔가무시 병으로 확진되었다. 환자 눈상태는 스테로이드 치료에 대해 반응을 보여 3주 후 안과적 검사상 호전되었고 6개월 후의 추적진료상에서도 정상이었다. 결론: 쯔쯔가무시병으로 결막염, 윤부염등은 보고된바 있으나 전포도막염을 동반한 경우는 그동안 보고된바가 없었다. 전포도막염은 전신상태 호전과 함께 스테로이드에 반응하였다.

Abstract

Purpose: To report a single case of tsutsugamushi disease with anterior uveitis and eschars on the upper eyelid. Case summary: A 56-year-old female patient complained of ocular pain and gradually decreasing visual acuity in her right eye. On physical examination, lymphadenopathy was palpable on the right side of the neck, and eschars were observed on the forehead and upper eyelid. On slit lamp examination, conjunctival injection, episcleral vessel dilations and severe intraocular inflammatory reaction were observed. Fundus examination showed no abnormal findings. A blood test was submitted for analysis, and tsutsugamushi disease was diagnosed. The patient’s ocular manifestations responded well to treatment with steroids. After three weeks, the patient showed improvement on ocular examination, and no problems were observed at the six-month follow-up. Conclusions: Although ocular manifestation of tsutusgamushi disease with conjunctivitis and limbitis has previously been reported, ocular manifestation of tsutusgamushi disease with anterior uveitis has not been reported. Anterior uveitis may respond satisfactorily to steroid treatment, along with improvement in systemic conditions.

참고문헌 (27)

  1. Tachibana N, "Tsutsugamushi disease", Jpn J Clin Med, 43, pp.728~732 (1985)
  2. Kim YW, "Patterns of Acute Febrile Illness (Murine Typhus, Scrub Typhus, Leptospirosis and Hemorrhagic Fever with Renal Syndrome) from 1986 to 1990 in Korea", J Korean Soc Microbiol, 26, pp.431~441 (1991)
  3. La Scola B, "Laboratory diagnosis of rickettsioses: current approaches to diagnosis of old and new rickettsial diseases", J Clin Microbiol, 35, pp.2715~2727 (1997)
  4. Suto T, "Rapid serologic diagnosis of tsutsugamushi disease employing the immunoperoxidase reaction with cell cultured rickettsia", Clin Virol, 8, pp.425~429 (1980)
  5. Seong SY, "Orientia tsutsugamushi infection: overview and immune responses", Microbes Infect, 3, pp.11~21 (2001)
  6. Ogawa M, "Scrub typhus in Japan: epidemiology and clinical features of cases reported in 1998", Am J Trop Med Hyg, 67, pp.162~165 (2002)
  7. Bang HA, "Comparative research on epidemiological aspects of tsutsugamushi disease (scrub typhus) between Korea and Japan", Jpn J Infect Dis, 61, pp.148~150 (2008)
  8. Ree HI, "Determination and geographical distribution of Orientia tsutsugamushi serotypes in Korea by nested polymersae chain reaction", Am J Trop Med Hyg, 65, pp.528~534 (2001)
  9. Tachibana N, "Tsutsugamushi disease", Jpn J Clin Med, 43, pp.728~732 (1985)
  10. Yamasaku F, "Handbook of internal medicine", pp.251~253 (1979), Nakayama-Shoten
  11. Yamashita T, "Newly isolated strains of Rickettsia tsutsugamushi in Japan identified by using monoclonal antibodies to Karp, Gilliam, and Kato strains", J Clin Microbiol, 26, pp.1859~1860 (1988)
  12. Chang WH, "Seroepidemiological Survey of Scrub Typhus in Korea", Infect Chemother, 26, pp.181~188 (1993)
  13. Kweon SS, "Rapid increase of scrub typhus, South Korea, 2001-2006", Emerg Infect Dis, 15, pp.1127~1129 (2009)
  14. Brown GW, "Scrub typhus;pathogenesis and clinical syndrome, Biology of rickettsial disease", pp.93~100 (1988), CRC Press
  15. Luksameetanasan R, "Patient and sample-related factors that effect the success of in vitro isolation of Orientia tsutsugamushi", Southeast Asian J Trop Med Public Health, 38, pp.91~96 (2007)
  16. Hanson B, "Identification and partial characterization of Rickettsia tsutsugamushi major protein immunogens", Infect Immun, 50, pp.603~609 (1985)
  17. Kim DM, "Usefulness of nested PCR for the diagnosis of scrub typhus in clinical practice:a prospective study", Am J Trop Med Hyg, 75, pp.542~545 (2006)
  18. Chi WC, "Scrub typhus associated with multiorgan failure: a case report", Scand J Infect Dis, 29, pp.634~635 (1997)
  19. 김동민, "Scrub Typhus:확진된 76예의 임상 소견에 대한 전향적 연구", Infection and Chemotherapy, 38(4), pp.186~191 (2006), 대한감염학회
  20. Kim DM, "Distribution of eschars on the body of scrub typhus patients: A prospective study", Am J Trop Med Hyg, 76, pp.806~809 (2007)
  21. 김소영, "하안검의 가피와 안질환을 동반한 쯔쯔가무시병 2 예", 대한안과학회지, 47(11), pp.1834~1839 (2006), 대한안과학회
  22. Kuwabara Y, "Iridocyclitis in tsutsugamushi disease", Jpn Rev Clin Ophthalmol, 15, pp.101~106 (1919)
  23. Yoneyama T, "An insect bite lesion of the eyelid in tsutsugamushi disease", Jpn J Clin Ophthalmol, 5, pp.752~753 (1951)
  24. Kato T, "Conjunctival Injection, Episcleral Vessel Dilatation, and Subconjunctival Hemorrhage in Patients with New Tsutsugamushi Disease", Jpn J Ophthalmol, 41, pp.196~199 (1997)
  25. Walker DH, "Rickettsial vasculitis", Am Heart J, 100, pp.896~906 (1980)
  26. Jerrells TR, "Development of specific and cross-reactive lymphocyte proliferative responses during chronic immunizing infections with Rickettsia tsutsugamushi", Infect Immun, 40, pp.147~156 (1983)
  27. Kang JI, "Acute sensorineural hearing loss and severe otalgia due to scrub typhus", BMC Inf Dis, 9, pp.173~ (2009)

관련 논문AI추천

이 간행물의 다른 논문 (19건)