비측 미숙아망막병증의 고찰
A Review of Nasal Retinopathy of Prematurity Cases
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목적: 비측 미숙아망막병증의 발생학적 임상양상과 원인에 대해 알아보고자 하였다. 대상과 방법: 레이저 광응고술을 받은 56명의 111안을 대상으로 하여 비측과 이측 미숙아망막병증을 구분하였고, 태생 시 및 첫 진단 시재태주수와 발생 위치, 레이저 치료 시점과 횟수에 대해 연구하였다. 결과: 비측 미숙아망막병증을 가진 환아는 33안(29.7%)이었고, 비측 미숙아망막병증 환아의 평균 재태주수는 28.43주로 이측 29.44주보다 빨랐다(p=0.022). 레이저 광응고술을 받은 평균 재태주수도 비측에서 36.61주로 39.71주의 이측보다 빨랐으며(p=0.001), 레이저평균 시행횟수는 2936.03회로 이측의 1611.83회보다 많았다(p=0.0001). 안저검사상 비측의 무혈관부위가 이측보다 넓은 환아는 없었으며 레이저 치료 후 진행률은 비측에서 33.3%, 이측에서 8.97%로 유의한 차이가 있었다(p=0.001). 결론: 비측 미숙아망막병증은 비전형적으로 비측 무혈관부위가 이측보다 넓기 때문이 아니라 비측에서 미숙아망막병증이 더 일찍 발생하기 때문이고, 이 경우에 더욱 심한 병의 경과를 가진다는 것을 알 수 있었다.
Abstract
Purpose: The present study evaluated the developmental characteristics and causes of nasal retinopathy of prematurity (ROP). Methods: A total of 111 eyes from 56 ROP-affected infants who had been treated with laser photocoagulation by retina specialists at the nasal site were examined. The gestational age at birth and diagnosis, location of the lesion, time, and number of laser photocoagulation therapies for nasal and temporal ROP were analyzed. Results: Thirty-three cases (29.7%) were diagnosed with nasal ROP. The mean gestational age at birth was 28.43 weeks for nasal ROP, and 29.44 weeks for temporal ROP (p = 0.022). Additionally, the average gestational age of infants who received laser photocoagulation was 36.61 weeks for nasal ROP, and 39.71 weeks for temporal ROP (p = 0.001). The average number of ROP laser photocoagulation trials was 2936.03 for nasal ROP, and 1611.83 for temporal ROP (p = 0.0001). No case was observed with a wider avascular area in the nasal retina than in the temporal retina. Additionally, compared to the temporal ROP, the nasal ROP showed significant difference in progression rates, 33.3% in the nasal group and 8.97% in the temporal group (p = 0.001). Conclusions: Nasal ROP was due to the ROP lesions developing earlier in the nasal than the temporal retina, although not due to any atypically wider nasal avascular area. In these cases, nasal ROP showed more disease progression compared to temporal ROP.
참고문헌 (26)
- Terry TL, "Retrolental fibroplasia in the premature infant: V. further studies on fibroplastic overgrowth of the persistent tunica vasculosa lentis", Trans Am Ophthalmol Soc, 42, pp.383~396 (1944)
- Hardy RJ, "Risk analysis of prethreshold retinopathy of prematurity", Arch Ophthalmol, 121, pp.1697~1701 (2003)
- Watts P, "Intraventricular haemorrhage and stage 3 retinopathy of prematurity", Br J Ophthalmol, 84, pp.596~599 (2000)
- Gibson DL, "Retinopathy of prematurity- induced blindness: birth weight-specific survival and new epidemic", Pediatrics, 86, pp.405~412 (1990)
- Nissenkorn I, "Myopia in premature babies with and without retinopathy of prematurity", Br J Ophthalmol, 67, pp.170~173 (1983)
- Hungerford J, "Ocular sequelae of preterm birth and their relation to ultrasound evidence of cerebral damage", Br J Ophthalmol, 70, pp.463~468 (1986)
- "Multicenter trial of cryotherapy for retinopathy of prematurity. Preliminary results. Cryotherapy for retinopathy of prematurity cooperative group", Arch Ophthalmol, 106, pp.471~479 (1988)
- "Multicenter trial of cryotherapy for retinopathy of prematurity. One-year outcome-structure and function. Cryotherapy for retinopathy of prematurity cooperative group", Arch Opthalmol, 108, pp.1408~1416 (1990)
- McNamara JA, "Laser photocoagulation for stage 3+ retinopathy of prematurity", Ophthalmology, 98, pp.576~580 (1991)
- Hunter DG, "Diode laser photocoagulation for threshold retinopathy of prematurity. A randomized study", Ophthalmology, 100, pp.238~244 (1993)
- Trese MT, "Scleral buckling for retinopathy of prematurity", Ophthalmology, 101, pp.23~26 (1994)
- Zilis JD, "Advanced retinopathy of prematurity. The anatomic and visual results of vitreous surgery", Ophthalmology, 97, pp.821~826 (1990)
- Keith CG, "4Ocular morbidity in infants of very low birth weight", Br J Ophthalmol, 67, pp.302~305 (1983)
- Tasman W, "Management of retinopathy of prematurity", Ophthalmology, 92, pp.995~999 (1985)
- Ben-Sira I, "Retinopathy of prematurity", Surv Ophthalmol, 33, pp.1~16 (1988)
- Noonan CP, "Trends in the management of stage 3 retinopathy of prematurity", Br J Ophthalmol, 80, pp.278~281 (1996)
- "Early treatment for retinopathy of prematurity cooperative group", Arch Ophthalmol, 121, pp.1684~1694 (2003)
- Cogan DG, "Development and senescence of the human retinal vasculature", Trans Ophthalmol Soc UK, 83, pp.465~489 (1963)
- Patz A, "The role of oxygen in retrolental fibroplasia. Pediatrics", Pediatrics, 504, pp.504~524 (1957)
- Donahue ML, "Retinal vascular endothelial growth factor (VEGF) mRNA expression is altered in relation to neovascularization in oxygen induced retinopathy", Curr Eye Res, 15, pp.175~184 (1996)
- Kretzer FL, "Vitamin E protects against retinopathy of prematurity through action on spindle cells", Nature, 309, pp.793~795 (1984)
- Flynn JT, "Retinopathy of prematurity", Pediatr Clin North Am, 34, pp.1487~1516 (1987)
- Michaelson IC, "The mode of development of the vascular system of the retina with some observations on its significance of certain retinal diseases", Trans Ophthalmol Soc UK, 68, pp.157~180 (1948)
- Nissenkorn I, "Nasal versus temporal preretinal vasoproliferation in retinopathy of prematurity", Br J Ophthalmol, 73, pp.747~749 (1989)
- Capone A Jr, "Diode-laser photocoagulation for zone I threshold retinopathy of prematurity", Am J Ophthal, 116, pp.444~450 (1993)
- Palmer EA, "Incidence and early course of retinopathy of prematurity", Ophthalmology, 98, pp.1628~1640 (1991)