Therapeutic Effect of Diode Laser Photodynamic Therapy with ICG Dye in ARMD: A Case Report
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Abstract
Purpose: To evaluate the diode laser photodynamic therapy efficacy on choroidal neovascularization (CNV) in the treatment of three patients with age-related macular degeneration (ARMD). Methods: The authors selected three patients with ARMD whose vision has decreased due to CNV, and applied diode laser treatment after injecting an indocyanine green (ICG) solution. The patients were followed for at least three months after treatment, and examinations included evaluating vision changes and possible leakage on fluorescein angiography (FAG). Results: The final vision of two patients improved by more than one line on the Early Treatment Diabetic Retinopathy Study (ETDRS) chart after at least three months of follow-up. However, the final vision of the third patient decreased by one line on ETDRS chart. FAG was done in all patients, and in two of the patients, there was no evidence of leakage at the laser-applied site. In the other patient, there was evidence of minimal leakage, with the area of leakage decreasing by more than fifty percent. Side effects of ICG were not found during or after the photodynamic therapy sessions. Conclusions: The photodynamic usage of ICG treatment of CNV in patients with ARMD, was effective in preventing or improving the visual outcome. Compared to the widely used verteporfin, ICG is more stable and is more cost effective. The authors therefore came to a conclusion that ICG can be very useful in the treatment of CNV. However, further studies are necessary.
참고문헌 (22)
- Bressler SB, "Natural course of choroidal neovascular membranes within the foveal avascular zone in senile macular degeneration", 93, pp.157~63 (1982)
- Guyer DR, "Subfoveal choroidal neovascular membranes in age-related macular degeneration", 104, pp.702~5 (1986)
- Klein BE, "Cataract and macular degeneration in older Americans", 104, pp.702~5 (1982)
- Ferris, "Senile macular degeneration:Review of epidemiologic features", 118, pp.132~51 (1983)
- Macular Photocoagulation Study Group, "Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration:results of a randomized clinical trial", 109, pp.1220~31 (1991)
- Bergink GJ, "A randomized controlled clinical trial of the efficacy of radiation therapy in the control of subfoveal choroidal neovascularization in age-related macular degeneration:radiation versus observation", 236, pp.321~325 (1998)
- Hart PM, "Therapy for subfoveal choroidal neovascularization of age-related macular degeneration:results of follow up in a non- randomized study", 80, pp.1046~1050 (1996)
- Macular Photocoagulation Study group, "Laser photocoagulation of subfoveal recurrent neovascular lesions in age- related macular degeneration:results of a randomized clinical trial", 109, pp.1232~41 (1991)
- Schimdt-Erfurth U, "In vivo uptake of liposomal benzoporphyrin derivative and photothrombosis in experimental corneal neovascularization", 17, pp.178~188 (1995)
- Thomas EL, "Closure of experimental subretinal neovascular vessels with dihematoporphyrin ether augmented argon green laser photocoagulation", 46, pp.881~6 (1987)
- Gomer CJ, "Preclinical examination of first and second generation photosensitizers used in photocynamic therapy", 54, pp.1093~107 (1991)
- Schmidt-Erfuth U, "Mechanisms of action of photodynamic therapy with Verteporfin for the treatment of age-related macular degeneration", 45, pp.195~214 (2000)
- Meredith TA, "Photodynamic therapy of subfoveal choroidal neovascularization (CNV) in age-related macular degeneration (AMD) using verteporfin: two-year results-VIP report #5 (ARVO Abstrac)", 42, pp.S304~ (2001)
- Miller JW, "Photodynamic therapy with Verteporfin for choroidal neovascularization caused by age-related macular degeneration:results of a single treatment in a phase1 and 2 study", 117, pp.1161~1173 (1999)
- Schmidt-Erfurth U, "Photodynamic therapy with Verteporfin for choroidal neovascularization caused by age-related macular degeneration:results of retreatment in a phase 1 and 2 study", 117, pp.1177~1187 (1999)
- Aveline B, "Photophysical and photosensitizing properties of benzoporphyrin derivative monoacir ring A(BPD-MA)", 59, pp.328~35 (1994)
- Flower RW, "Clinical infrared absorption angiography of the choroid", 73, pp.458~9 (1972)
- Puliafito Ca, "Dye-enhanced photocoagulation of choroidal neovascularization", 29, pp.414~9 (1988)
- Fox I, "New dyes for continuous recording of dilution curves in whole blood independent of variations in blood oxygen saturation", 187, pp.599~606 (1956)
- Bracanto R, "Histopathology of diode laser and argon laser in rabbit retina", 30, pp.1504~10 (1989)
- Akira Obana, "A retrospective pilot study of indocyanine green enhanced diode laser photocoagulation for subfoveal choroidal neovascularization associated with age-related macular degeneration", 44, pp.668~676 (2000)
- Kang BD, "The effect of photodynamic therapy with ICG in the treatment of CNV", 45, pp.2119~2126 (2004)