스트레스가 안압 및 눈물분비에 미치는 영향
The Effects of Stress on Intraocular Pressure and Lacrimal Secretion
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목적: 정신 사회적 스트레스가 안압 및 눈물분비에 미치는 영향에 대하여 알아보고자 하였다. 대상과 방법: 임상시험 공고를 통하여 모집된 사람 중 전신 질환이나 안구 건조증, 녹내장 등을 포함한 안 질환이 없는 20명, 40안을대상으로 하였다. Trier Social Stress Test (TSST)를 시행하여 정신사회적 스트레스를 유발 후 심장 박동수, 안압 및 눈물분비량을 측정하였다. 1주 후 스트레스가 완전히 완화된 상태에서 심장 박동수, 안압 및 눈물분비량을 다시 측정하여 그 수치를 대조군으로 하였다. 결과: TSST 후 심장 박동수가 유의하게 증가하여(p=0.000) 스트레스가 유발된 것을 알 수 있었다. 스트레스 완화 상태와 비교하였을때 TSST 후 평균 안압은 증가하였으며(p=0.027), 눈물 분비량 또한 증가하였다(p=0.011). 성별에 따라 분류하였을 때 남성에서는 평균안압과 눈물 분비량의 증가가 유의한 반면(p=0.031, p=0.007) 여성에서는 유의하지 않았다(p=0.336, p=0.554). 결론: 정신사회적 스트레스는 안압의 상승과 눈물 분비량의 증가를 유발할 수 있다.
Abstract
Purpose: To evaluate the effects of psychosocial stress on intraocular pressure and lacrimal secretion. Methods: Twenty normal adult volunteers (40 eyes) who had no history of systemic or ocular disease such as dry eye syndrome or glaucoma were recruited from clinical research participants. Heart rate, intraocular pressure and lacrimal secretion were measured after the Trier Social Stress Test (TSST) which induces psychosocial stress. The same measurements were taken 1 week later and the recorded measurements were considered as the control group. Results: Heart rate was elevated significantly after the TSST, indicating psychosocial stress was induced by the TSST. Compared to stress resolution status, intraocular pressure and lacrimal secretion were increased after the TSST (p =0.027, p = 0.011). Elevation of intraocular pressure and lacrimal secretion was statistically significant in males (p = 0.031,p = 0.007), but not significant in females (p = 0.336, p = 0.554). Conclusions: Psychosocial stress can increase intraocular pressure and lacrimal secretion.
참고문헌 (34)
- Hobfoll SE, "Conservation of resources. A new attempt at conceptualizing stress", Am Psychol, 44, pp.513~524 (1989)
- Theorell T, "Slow-reacting immunoglobulin in relation to social support and changes in job strain: a preliminary note", Psychosom Med, 52, pp.511~516 (1990)
- Brosschot JF, "Influence of life stress on immunological reactivity to mild psychological stress", Psychosom Med, 56, pp.216~224 (1994)
- Lederer CM Jr, "Drop size of commercial glaucoma medications", Am J Ophthalmol, 101, pp.691~694 (1986)
- Toris CB, "Effects of apraclonidine on aqueous humor dynamics in human eyes", Ophthalmology, 102, pp.456~461 (1995)
- Yoon DH, "Glaucoma, 4th ed", pp.190~191 (2008), Korean Glaucoma Society
- Kim SY, "Cornea, 2nd ed", pp.272~274 (2005), Society TKEED
- Hodges RR, "Regulatory pathways in lacrimal gland epithelium", Int Rev Cytol, 231, pp.129~196 (2003)
- Kirschbaum C, "The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting", Neuropsychobiology, 28, pp.76~81 (1993)
- Jemmott JB 3rd, "Psychosocial factors, immunologic mediation, and human susceptibility to infectious diseases: how much do we know?", Psychol Bull, 95, pp.78~108 (1984)
- Selye H, "Stress and the general adaptation syndrome", Br Med J, 1, pp.1383~1392 (1950)
- Kudielka BM, "Acute HPA axis responses, heart rate, and mood changes to psychosocial stress (TSST) in humans at different times of day", Psychoneuroendocrinology, 29, pp.983~992 (2004)
- Charmandari E, "Endocrinology of the stress response", Annu Rev Physiol, 67, pp.259~284 (2005)
- Andersen ML, "Different stress modalities result in distinct steroid hormone responses by male rats", Braz J Med Biol Res, 37, pp.791~797 (2004)
- von Dawans B, "The Trier Social Stress Test for Groups (TSST-G): A new research tool for controlled simultaneous social stress exposure in a group format", Psychoneuroendocrinology, 36, pp.514~522 (2011)
- Kudielka BM, "Differential heart rate reactivity and recovery after psychosocial stress (TSST) in healthy children, younger adults, and elderly adults: the impact of age and gender", Int J Behav Med, 11, pp.116~121 (2004)
- Buske-Kirschbaum A, "Attenuated free cortisol response to psychosocial stress in children with atopic dermatitis", Psychosom Med, 59, pp.419~426 (1997)
- Eglen RM, "Therapeutic opportunities from muscarinic receptor research", Trends Pharmacol Sci, 22, pp.409~414 (2001)
- Büscher R, "Human adrenoceptor polymorphisms: evolving recognition of clinical importance", Trends Pharmacol Sci, 20, pp.94~99 (1999)
- Yamamoto K, "The relationship between IMPS-measured stress score and intraocular pressure among public school workers", J Physiol Anthropol, 27, pp.43~50 (2008)
- Brody S, "Intraocular pressure changes: the influence of psychological stress and the Valsalva maneuver", Biol Psychol, 51, pp.43~57 (1999)
- Kass MA, "Hormonal regulation of intraocular pressure", Surv Ophthalmol, 22, pp.153~176 (1977)
- Haas JS, "Glaucoma secondary to benign adrenal adenoma", Am J Ophthalmol, 78, pp.497~500 (1974)
- Camras CB, "The role of endogenous prostaglandins in clinically-used and investigational glaucoma therapy", Prog Clin Biol Res, 312, pp.459~475 (1989)
- Krupin T, "Decreased basal tear production associated with general anesthesia", Arch Ophthalmol, 95, pp.107~108 (1977)
- Seifert P, "Distribution pattern of nervous tissue and peptidergic nerve fibers in accessory lacrimal glands", Curr Eye Res, 16, pp.298~302 (1997)
- Dartt DA, "Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases", Prog Retin Eye Res, 28, pp.155~177 (2009)
- Dartt DA, "Vasoactive intestinal polypeptide stimulation of protein secretion from rat lacrimal gland acini", Am J Physiol, 247(5 Pt 1), pp.502~509 (1984)
- Ding C, "Sympathetic neural control of the mouse lacrimal gland", Invest Ophthalmol Vis Sci, 44, pp.1513~1520 (2003)
- Yasui T, "Correlation between vasodilatation and secretion in the lacrimal gland elicited by stimulation of the cornea and facial nerve root of the cat", Invest Ophthalmol Vis Sci, 38, pp.2476~2482 (1997)
- Meneray MA, "Effect of sensory denervation on the structure and physiologic responsiveness of rabbit lacrimal gland", Cornea, 17, pp.99~107 (1998)
- Dartt DA, "Alpha 1-adrenergic agonist- stimulated protein secretion in rat exorbital lacrimal gland acini", Exp Eye Res, 58, pp.423~429 (1994)
- Seeman TE, "Gender differences in age-related changes in HPA axis reactivity", Psychoneuroendocrinology, 26, pp.225~240 (2001)
- Traustadóttir T, "Gender differences in cardiovascular and hypothalamic-pituitary-adrenal axis responses to psychological stress in healthy older adult men and women", Stress, 6, pp.133~140 (2003)