상측분절시신경형성부전 환자와 정상안압녹내장 환자의 망막신경섬유층 두께 비교
Analysis of Retinal Nerve Fiber Layer Thickness of Superior Segmental Optic Hypoplasia and Normal-Tension Glaucoma
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목적: 상측분절시신경형성부전(SSOH)환자와 하부시야에 이상을 보이는 정상안압녹내장(NTG)환자에서 빛간섭단층촬영을 이용하여 측정한 망막신경섬유층을 비교 분석하고자 하였다. 대상과 방법: SSOH군과 NTG군 각각 10안을 대상으로 임상양상을 살펴보고 빛간섭단층촬영을 시행하여 망막신경섬유층의 두께를 측정한 후 비교하여 분석하였다. 결과: 망막신경섬유층의 평균두께는 SSOH군 79.60 ± 12.54 μm, NTG군 77.10 ± 8.52 μm로 유의한 차이를 보이지 않았으며(p=0.089),4사분역의 망막신경섬유층 두께도 두 군에서 차이가 없었으나(p＞0.05), 상측과 상비측에 해당하는 12, 1, 2시 방향에서 NTG군이 SSOH 군에 비해 유의하게 망막신경섬유층이 두꺼웠으며(p=0.029, 0.007, 0.043), 하이측에 해당하는 6, 7시는 SSOH군이 NTG군에 비해유의하게 망막신경섬유층이 두꺼웠다(p=0.029, 0.007). 결론: NTG환자와 SSOH환자의 망막신경섬유층의 두께를 비교하였을 때, SSOH환자가 상비측은 얇았으나, 하이측은 두꺼운 것으로 나타나, 두 질병의 망막신경섬유층의 결손 형태에 차이가 있었다.
Abstract
Purpose: To analyze the peripapillary retinal nerve fiber layer (RNFL) in superior segmental optic hypoplasia (SSOH) patients and normal tension glaucoma (NTG) patients with inferior visual field defects using optical coherence tomography (OCT). Methods: Ten eyes of 10 patients with SSOH and 10 eyes of 10 patients with NTG were evaluated. The peripapillary RNFL thickness measured by OCT was compared between the 2 groups. Results: The mean RNFL thickness was not significantly different between SSOH patients (79.60 ± 12.54 μm) and NTG patients (77.10 ± 8.52 μm) (p = 0.089). Among the quadrant parameters, there were no significant differences between the 2 groups (p > 0.05). In a clock-hour analysis, the peripapillary RNFL thickness of the NTG group was significantly thicker than the SSOH group in 12, 1, and 2 o’clock (p = 0.029, 0.007, 0.043, respectively). In contrast, the peripapillary RNFL thickness of the SSOH group was significantly thicker than the SSOH group in 6, and 7 o’clock (p = 0.029, 0.007, respectively). Conclusions: Peripapillary RNFL thickness in patients with SSOH was thinner than in those with NTG in the superonasal region, but thicker in the inferotemporal region indicating a different retinal nerve fiber defect pattern between the 2diseases.
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