Current Practice Pattern for Dry Eye Patients in South Korea: A Multicenter Study
3
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Purpose: To assess current practice patterns for dry eye patients in South Korea and to evaluate the preferenceaccording to the ages and clinic types of physicians. Methods: Dry eye patients (n = 1,612) were enrolled in this multicenter cross-sectional, observational study. Theseverity level of dry eye patients was classified based on the Korean guidelines for dry eye treatment. Themedical records of the enrolled dry eye patients were evaluated, and the practice styles and the preferenceswere analyzed according to the ages and clinic types of physicians. Results: Of all patients, dry eye level 1 was most common (47.5%), followed by level 2 (33.5%), level 3 (9.1%), andlevel 4 (1.1%). Topical anti-inflammatory agents were used in 70.7% of patients with dry eye level 2 and in 80.6%of patients at levels 3 and 4. Topical anti-inflammatory agents were also used in 48.7% of patients with dry eyelevel 1. Preservative-free artificial tears were preferred at all dry eye levels. The use of topical anti-inflammatoryagents did not differ with investigator ages, but older physicians preferred preserved artificial tears more thanyounger ones. Physicians at referral hospitals also tended to use topical anti-inflammatory agents and preservative-free artificial tears earlier, beginning at dry eye level 1, than those who worked at private eye clinics. Conclusions: Topical anti-inflammatory agents were commonly prescribed for the treatment of dry eye patientsin South Korea, even from dry eye level 1. Preservative-free artificial tears were preferred at all dry eye levels. Practice styles differed somewhat depending on the ages and clinic types of physicians.
Abstract
Purpose: To assess current practice patterns for dry eye patients in South Korea and to evaluate the preferenceaccording to the ages and clinic types of physicians. Methods: Dry eye patients (n = 1,612) were enrolled in this multicenter cross-sectional, observational study. Theseverity level of dry eye patients was classified based on the Korean guidelines for dry eye treatment. Themedical records of the enrolled dry eye patients were evaluated, and the practice styles and the preferenceswere analyzed according to the ages and clinic types of physicians. Results: Of all patients, dry eye level 1 was most common (47.5%), followed by level 2 (33.5%), level 3 (9.1%), andlevel 4 (1.1%). Topical anti-inflammatory agents were used in 70.7% of patients with dry eye level 2 and in 80.6%of patients at levels 3 and 4. Topical anti-inflammatory agents were also used in 48.7% of patients with dry eyelevel 1. Preservative-free artificial tears were preferred at all dry eye levels. The use of topical anti-inflammatoryagents did not differ with investigator ages, but older physicians preferred preserved artificial tears more thanyounger ones. Physicians at referral hospitals also tended to use topical anti-inflammatory agents and preservative-free artificial tears earlier, beginning at dry eye level 1, than those who worked at private eye clinics. Conclusions: Topical anti-inflammatory agents were commonly prescribed for the treatment of dry eye patientsin South Korea, even from dry eye level 1. Preservative-free artificial tears were preferred at all dry eye levels. Practice styles differed somewhat depending on the ages and clinic types of physicians.
참고문헌 (16)
- Pflugfelder SC, "Altered cytokine balance in the tear f luid and conjunctiva of patients with Sjogren’s syndrome keratoconjunctivitis sicca", Curr Eye Res, 19, pp.201~211 (1999)
- Tsubota K, "Conjunctival epithelium expression of HLA-DR in dry eye patients", Ophthalmologica, 213, pp.16~19 (1999)
- Li DQ, "Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells", Invest Ophthalmol Vis Sci, 45, pp.4302~4311 (2004)
- De Paiva CS, "Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye", Exp Eye Res, 83, pp.526~535 (2006)
- Baudouin C, "The pathology of dry eye", Surv Ophthalmol, 45(Suppl 2), pp.S211~S220 (2001)
- Turner K, "Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion", Cornea, 19, pp.492~496 (2000)
- Brignole F, "Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A", Invest Ophthalmol Vis Sci, 42, pp.90~95 (2001)
- Kunert KS, "Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine", Arch Ophthalmol, 120, pp.330~337 (2002)
- Behrens A, "Dysfunctional tear syndrome:a Delphi approach to treatment recommendations", Cornea, 25, pp.900~907 (2006)
- "Management and therapy of dry eye disease: report of the Management and Therapy Subcommittee of the International Dry Eye WorkShop (2007)", Ocul Surf, 5, pp.163~178 (2007)
- Jackson WB, "Management of dysfunctional tear syndrome:a Canadian consensus", Can J Ophthalmol, 44, pp.385~394 (2009)
- Wilson SE, "Agreement of physician treatment practices with the international task force guidelines for diagnosis and treatment of dry eye disease", Cornea, 26, pp.284~289 (2007)
- Gasset AR, "Cytotoxicity of ophthalmic preservatives", Am J Ophthalmol, 78, pp.98~105 (1974)
- Wilson FM 2nd, "Adverse external ocular effects of topical ophthalmic medications", Surv Ophthalmol, 24, pp.57~88 (1979)
- Burstein NL, "Corneal cytotoxicity of topically applied drugs, vehicles and preservatives", Surv Ophthalmol, 25, pp.15~30 (1980)
- Nelson JD, "Simultaneous evaluation of tear turnover and corneal epithelial permeability by fluorophotometry in normal subjects and patients with keratoconjunctivitis sicca (KCS)", Trans Am Ophthalmol Soc, 93, pp.709~753 (1995)