Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis
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Purpose: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS)patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine thepresence of antibodies against Toxocara canis in AS patients with ANGAU. Methods: Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAUwas accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determinedby enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were alsotested to verify non-specific reactions. Results: The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients withANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positivefor T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens inthe serum samples of patients with AS. Conclusions: These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patientswith AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated withthe pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation.
Abstract
Purpose: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS)patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine thepresence of antibodies against Toxocara canis in AS patients with ANGAU. Methods: Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAUwas accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determinedby enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were alsotested to verify non-specific reactions. Results: The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients withANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positivefor T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens inthe serum samples of patients with AS. Conclusions: These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patientswith AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated withthe pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation.
참고문헌 (31)
- Rosenbaum JT, "Acute anterior uveitis and spondyloarthropathies", Rheum Dis Clin North Am, 18, pp.143~151 (1992)
- Gran JT, "The outcome of ankylosing spondylitis:a study of 100 patients", Br J Rheumatol, 36, pp.766~771 (1997)
- Robertson LP, "A longitudinal study of disease activity and functional status in a hospital cohort of patients with ankylosing spondylitis", Rheumatology, 43, pp.1565~1568 (2004)
- Smith JR, "HLA-B27: associated uveitis", Ophthalmol Clin North Am, 15, pp.297~307 (2002)
- Quinnell RJ, "Genetics of susceptibility to human helminth infection", Int J Parasitol, 33, pp.1219~1231 (2003)
- Despommier D, "Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects", Clin Microbiol Rev, 16, pp.265~272 (2003)
- Rubinsky-Elefant G, "Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms", Ann Trop Med Parasitol, 104, pp.3~23 (2010)
- Bocanegra TS, "Musculoskeletal syndromes in parasitic diseases", Rheum Dis Clin North Am, 19, pp.505~513 (1993)
- Zaccone P, "Parasitic worms and inflammatory diseases", Parasite Immunol, 28, pp.515~523 (2006)
- Peng SL, "Rheumatic manifestations of parasitic diseases", Semin Arthritis Rheum, 31, pp.228~247 (2002)
- Williams D, "Arthritis and arthralgia associated with toxocaral infestation", Br Med J (Clin Res Ed), 283, pp.192~ (1981)
- Brocq O, "Reactive arthritis induced by Strongyloides stercoralis", Rev Rhum Engl Ed, 63, pp.217~219 (1996)
- Richter J, "Arthritis associated with Strongyloides stercoralis infection in HLA B-27-positive African", Parasitol Res, 99, pp.706~707 (2006)
- Kuk S, "Seroprevalance of toxocara antibodies in multiple sclerosis and ankylosing spondylitis", Indian J Med Sci, 60, pp.297~299 (2006)
- Van der Linden S, "Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria", Arthritis Rheum, 27, pp.361~368 (1984)
- Jimenez-Balderas FJ, "A study on parasites in Mexican rheumatic disease patients", J Egypt Soc Parasitol, 42, pp.271~280 (2012)
- Altman DG, "Practical statistics for medical research", pp.229~276 (1991), Chapman and Hall
- Embil JA, "Seroepidemiologic survey of Toxocara canis infection in urban and rural children", Public Health, 102, pp.129~133 (1988)
- Park SP, "Five cases of ocular toxocariasis confirmed by serology", Korean J Parasitol, 38, pp.267~273 (2000)
- Elefant GR, "A serological follow-up of toxocariasis patients after chemotherapy based on the detection of IgG, IgA, and IgE antibodies by enzyme-linked immunosorbent assay", J Clin Lab Anal, 20, pp.164~172 (2006)
- De Visser L, "Diagnosis of ocular toxocariasis by establishing intraocular antibody production", Am J Ophthalmol, 145, pp.369~374 (2008)
- Tinoco-Gracia L, "Seroprevalence of larva migrans of toxocara canis and evaluation of associated risk factors among children in a mexico-united states border region", Int J Appl Res Vet Med, 6, pp.130~136 (2008)
- Romero-Nunez C, "Presence and viability of Toxocara spp in soils public parks, gardens and houses in dog feces Nezahualcoyotl, Mexico", Rev Cient, 21, pp.195~201 (2011)
- Romero-Nunez C, "Prevalence and risk factors associated with toxocara canis infection in children", ScientificWorldJournal, 2013, pp.572089~ (2013)
- Ponce-Macotela M, "Medical parasitology", pp.249~256 (2004), Mcgraw-Hill-Inter-americana
- Martinez-Barbabosa I, "Prevalence of anti-T. canis antibodies in stray dogs in Mexico City", Vet Parasitol, 153, pp.270~276 (2008)
- Barisani-Asenbauer T, "Treatment of ocular toxocariasis with albendazole", J Ocul Pharmacol Ther, 17, pp.287~294 (2001)
- Khan MA, "Comparison of clinical features in HLA-B27 positive and negative patients with ankylosing spondylitis", Arthritis Rheum, 20, pp.909~912 (1977)
- Jaakkola E, "Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis", Ann Rheum Dis, 65, pp.775~780 (2006)
- Niederer R, "Uveitis screening: HLAB27antigen and ankylosing spondylitis in a New Zealand population", N Z Med J, 119, pp.U1886~ (2006)
- Braakenburg AM, "Human leukocyte antigen-B27-associated uveitis: long-term follow-up and gender differences", Am J Ophthalmol, 145, pp.472~479 (2008)