Autologous Platelet-rich Plasma Eye Drops in the Treatment of Recurrent Corneal Erosions
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Purpose: To evaluate the effect of platelet-rich plasma (PRP) eye drops in the treatment of recurrent cornealerosions (RCE). Methods: A total of 47 eyes were included in this retrospective study. Clinical records of 20 consecutive patientswith RCE who had been treated with conventional lubricant eye drops (conventional treatment group) fromJune 2006 to December 2008 and 27 consecutive patients treated with autologous PRP eye drops in additionto lubricant eye drops (PRP eye drops treated group) from January 2009 to September 2014 were reviewed. Major and minor recurrences were recorded and compared between two groups. Results: This study included 31 men and 16 women. The mean age was 44.5 ± 14.5 years (range, 19 to 86years), and the mean follow-up duration was 14.9 ± 14.4 months (range, 6 to 64 months). Of the 27 casesin the PRP eye drops treated group, there were seven major recurrences in six eyes (22.2%) and ten minorrecurrences in seven eyes (25.9%). In contrast, 16 eyes (80.0%) from the 20 patients in the conventional lubricanteye drops treated group had major recurrences, and all patients in this group reported minor recurrences. The mean frequency of recurrence was 0.06 ± 0.08 per month in the PRP eye drops treated group and 0.39 ±0.24 per month in the conventional treatment group (p = 0.003). No side effects were noted in any of the patientsover the follow-up period. Conclusions: The use of PRP eye drops for the treatment of RCE was shown to be effective in reducing therecurrence rate without any significant complications.
Abstract
Purpose: To evaluate the effect of platelet-rich plasma (PRP) eye drops in the treatment of recurrent cornealerosions (RCE). Methods: A total of 47 eyes were included in this retrospective study. Clinical records of 20 consecutive patientswith RCE who had been treated with conventional lubricant eye drops (conventional treatment group) fromJune 2006 to December 2008 and 27 consecutive patients treated with autologous PRP eye drops in additionto lubricant eye drops (PRP eye drops treated group) from January 2009 to September 2014 were reviewed. Major and minor recurrences were recorded and compared between two groups. Results: This study included 31 men and 16 women. The mean age was 44.5 ± 14.5 years (range, 19 to 86years), and the mean follow-up duration was 14.9 ± 14.4 months (range, 6 to 64 months). Of the 27 casesin the PRP eye drops treated group, there were seven major recurrences in six eyes (22.2%) and ten minorrecurrences in seven eyes (25.9%). In contrast, 16 eyes (80.0%) from the 20 patients in the conventional lubricanteye drops treated group had major recurrences, and all patients in this group reported minor recurrences. The mean frequency of recurrence was 0.06 ± 0.08 per month in the PRP eye drops treated group and 0.39 ±0.24 per month in the conventional treatment group (p = 0.003). No side effects were noted in any of the patientsover the follow-up period. Conclusions: The use of PRP eye drops for the treatment of RCE was shown to be effective in reducing therecurrence rate without any significant complications.
참고문헌 (34)
- Dursun D, "Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids", Am J Ophthalmol, 132, pp.8~13 (2001)
- Hope-Ross MW, "Oral tetracycline in the treatment of recurrent corneal erosions", Eye (Lond), 8(Pt 4), pp.384~388 (1994)
- Buxton JN, "Superficial epithelial keratectomy in the treatment of epithelial basement membrane dystrophy:a preliminary report", Arch Ophthalmol, 101, pp.392~395 (1983)
- Soong HK, "Diamond burr superficial keratectomy for recurrent corneal erosions", Br J Ophthalmol, 86, pp.296~298 (2002)
- McLean EN, "Recurrent erosion:treatment by anterior stromal puncture", Ophthalmology, 93, pp.784~788 (1986)
- 김서영, "난치성 반복각막진무름에서 엔디야그레이저전측각막실질 미세천자술", 대한안과학회지, 56(3), pp.331~338 (2015), 대한안과학회
- 최문정, "반복각막진무름에서 Nd:YAG Laser 치료와 보존적 치료의 비교", 대한안과학회지, 56(5), pp.687~693 (2015), 대한안과학회
- Forster W, "Phototherapeutic keratectomy in corneal diseases", Refract Corneal Surg, 9(2Suppl), pp.S85~S90 (1993)
- Nishida T, "Synergistic effects of substance P with insulin-like growth factor-1 on epithelial migration of the cornea", J Cell Physiol, 169, pp.159~166 (1996)
- van Setten GB, "Epidermal growth factor is a constant component of normal human tear fluid", Graefes Arch Clin Exp Ophthalmol, 227, pp.184~187 (1989)
- Gupta A, "Transforming growth factor beta-1 and beta-2 in human tear fluid", Curr Eye Res, 15, pp.605~614 (1996)
- Liu L, "An optimised protocol for the production of autologous serum eyedrops", Graefes Arch Clin Exp Ophthalmol, 243, pp.706~714 (2005)
- Tsubota K, "Treatment of dry eye by autologous serum application in Sjogren’s syndrome", Br J Ophthalmol, 83, pp.390~395 (1999)
- Ogawa Y, "Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease", Bone Marrow Transplant, 31, pp.579~583 (2003)
- Noble BA, "Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease", Br J Ophthalmol, 88, pp.647~652 (2004)
- Kojima T, "The effect of autologous serum eyedrops in the treatment of severe dry eye disease: a prospective randomized case-control study", Am J Ophthalmol, 139, pp.242~246 (2005)
- Tananuvat N, "Controlled study of the use of autologous serum in dry eye patients", Cornea, 20, pp.802~806 (2001)
- Tsubota K, "Treatment of persistent corneal epithelial defect by autologous serum application", Ophthalmology, 106, pp.1984~1989 (1999)
- Poon AC, "Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies", Br J Ophthalmol, 85, pp.1188~1197 (2001)
- Young AL, "The use of autologous serum tears in persistent corneal epithelial defects", Eye (Lond), 18, pp.609~614 (2004)
- Jeng BH, "Autologous serum 50% eyedrops in the treatment of persistent corneal epithelial defects", Cornea, 28, pp.1104~1108 (2009)
- Matsumoto Y, "Autologous serum application in the treatment of neurotrophic keratopathy", Ophthalmology, 111, pp.1115~1120 (2004)
- del Castillo JM, "Treatment of recurrent corneal erosions using autologous serum", Cornea, 21, pp.781~783 (2002)
- Knighton DR, "Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet-derived wound healing formula", Surg Gynecol Obstet, 170, pp.56~60 (1990)
- Lynch SE, "Growth factors in wound healing: single and synergistic effects on partial thickness porcine skin wounds", J Clin Invest, 84, pp.640~646 (1989)
- Alio JL, "Use of autologous platelet-rich plasma in the treatment of dormant corneal ulcers", Ophthalmology, 114, pp.1286.e1~1293.e1 (2007)
- Alio JL, "Treatment of ocular surface syndrome after LASIK with autologous platelet-rich plasma", J Refract Surg, 23, pp.617~619 (2007)
- Kim KM, "Effect of autologous platelet-rich plasma on persistent corneal epithelial defect after infectious keratitis", Jpn J Ophthalmol, 56, pp.544~550 (2012)
- Marx RE, "Platelet-rich plasma: growth factor enhancement for bone grafts", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 85, pp.638~646 (1998)
- Peng Y, "Platelet rich plasma clot releasate preconditioning induced PI3K", AKT, Stem Cells Dev, pp.2013, 22[DOI]
- Holzer MP, "Combination of transepithelial phototherapeutic keratectomy and autologous serum eyedrops for treatment of recurrent corneal erosions", J Cataract Refract Surg, 31, pp.1603~1606 (2005)
- Hartwig D, "Epitheliotrophic capacity of a growth factor preparation produced from platelet concentrates on corneal epithelial cells: a potential agent for the treatment of ocular surface defects?", Transfusion, 44, pp.1724~1731 (2004)
- Sakimoto T, "Upregulation of matrix metalloproteinase in tear fluid of patients with recurrent corneal erosion", Jpn J Ophthalmol, 51, pp.343~346 (2007)
- Nurden AT, "Platelets, inflammation and tissue regeneration", Thromb Haemost, 105(Suppl 1), pp.S13~S33 (2011)