Optical Coherence Tomography-based Diagnosis of Polypoidal Choroidal Vasculopathy in Korean Patients
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Purpose: To evaluate the efficacy of an optical coherence tomography (OCT)-based diagnosis of polypoidalchoroidal vasculopathy (PCV) in Korean patients. Methods: This retrospective, observational case series included 263 eyes of 263 patients (147 eyes with PCVand 116 eyes with typical exudative, age-related macular degeneration [AMD]) who had been diagnosed withtreatment naïve exudative AMD. Eyes with three or more of the following OCT findings were diagnosed withPCV: multiple retinal pigment epithelial detachment (RPED), a sharp RPED peak, an RPED notch, a hyporeflectivelumen representing polyps, and hyperreflective intraretinal hard exudates. The OCT-based diagnosiswas compared with the gold-standard indocyanine green angiography-based method. The sensitivity andspecificity of the OCT-based diagnosis was also estimated. An additional analysis was performed using achoroidal thickness criterion. Eyes with a subfoveal choroidal thickness greater than 300 μm were also diagnosedwith PCV despite having only two OCT features. Results: In eyes with PCV, three or more OCT features were observed in 126 of 147 eyes (85.7%), and the incidenceof typical exudative AMD was 16 of 116 eyes (13.8%). The sensitivity and specificity of an OCT-baseddiagnosis were 85.7% and 86.2%, respectively. After applying the choroidal thickness criterion, the sensitivityincreased from 85.7% to 89.8%, and the specificity decreased from 86.2% to 84.5%. Conclusions: The OCT-based diagnosis of PCV showed a high sensitivity and specificity in Korean patients. The addition of a choroidal thickness criterion improved the sensitivity of the method with a minimal decreasein its specificity.
Abstract
Purpose: To evaluate the efficacy of an optical coherence tomography (OCT)-based diagnosis of polypoidalchoroidal vasculopathy (PCV) in Korean patients. Methods: This retrospective, observational case series included 263 eyes of 263 patients (147 eyes with PCVand 116 eyes with typical exudative, age-related macular degeneration [AMD]) who had been diagnosed withtreatment naïve exudative AMD. Eyes with three or more of the following OCT findings were diagnosed withPCV: multiple retinal pigment epithelial detachment (RPED), a sharp RPED peak, an RPED notch, a hyporeflectivelumen representing polyps, and hyperreflective intraretinal hard exudates. The OCT-based diagnosiswas compared with the gold-standard indocyanine green angiography-based method. The sensitivity andspecificity of the OCT-based diagnosis was also estimated. An additional analysis was performed using achoroidal thickness criterion. Eyes with a subfoveal choroidal thickness greater than 300 μm were also diagnosedwith PCV despite having only two OCT features. Results: In eyes with PCV, three or more OCT features were observed in 126 of 147 eyes (85.7%), and the incidenceof typical exudative AMD was 16 of 116 eyes (13.8%). The sensitivity and specificity of an OCT-baseddiagnosis were 85.7% and 86.2%, respectively. After applying the choroidal thickness criterion, the sensitivityincreased from 85.7% to 89.8%, and the specificity decreased from 86.2% to 84.5%. Conclusions: The OCT-based diagnosis of PCV showed a high sensitivity and specificity in Korean patients. The addition of a choroidal thickness criterion improved the sensitivity of the method with a minimal decreasein its specificity.
참고문헌 (22)
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