Orbital Lymphangioma: Characteristics and Treatment Outcomes of 12 Cases
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Purpose: To report the patient characteristics and treatment outcomes in 12 cases of orbital lymphangioma. Methods: In this study, orbital lymphangioma was diagnosed based on clinical, radiologic (computed tomography,magnetic resonance imaging), and histologic findings when possible. Patients whose vision was notcompromised by orbital lymphangioma, or that did not have increased intraocular pressure (IOP), receivedoral corticosteroids. Orbital lymphangioma that affected vision or increased IOP was treated by surgery, whichincluded aspiration of blood or partial resection with or without injection of a sclerosant. Results: Four patients without compromised vision responded well to oral corticosteroids. Eight patients withcompromised vision underwent some form of surgery. Bleeding recurred in three patients after aspiration ofblood and in two after partial resection and intralesional injection of a sclerosant. Overall, five patients weretreated successfully by aspiration of blood, intralesional injection of a sclerosant, and application of continuousnegative pressure by appropriate drainage. Partial resection was successful in two patients with organized hematoma. Conclusions: Orbital lymphangioma that does not compromise vision can be treated medically using oral corticosteroids. Patients with threatened vision or elevated IOP due to acute hemorrhage should be treated by aspirationof blood, intralesional injection of a sclerosant, and application of continuous negative pressure. Partialresection may be effective only in patients with organized hematoma.
Abstract
Purpose: To report the patient characteristics and treatment outcomes in 12 cases of orbital lymphangioma. Methods: In this study, orbital lymphangioma was diagnosed based on clinical, radiologic (computed tomography,magnetic resonance imaging), and histologic findings when possible. Patients whose vision was notcompromised by orbital lymphangioma, or that did not have increased intraocular pressure (IOP), receivedoral corticosteroids. Orbital lymphangioma that affected vision or increased IOP was treated by surgery, whichincluded aspiration of blood or partial resection with or without injection of a sclerosant. Results: Four patients without compromised vision responded well to oral corticosteroids. Eight patients withcompromised vision underwent some form of surgery. Bleeding recurred in three patients after aspiration ofblood and in two after partial resection and intralesional injection of a sclerosant. Overall, five patients weretreated successfully by aspiration of blood, intralesional injection of a sclerosant, and application of continuousnegative pressure by appropriate drainage. Partial resection was successful in two patients with organized hematoma. Conclusions: Orbital lymphangioma that does not compromise vision can be treated medically using oral corticosteroids. Patients with threatened vision or elevated IOP due to acute hemorrhage should be treated by aspirationof blood, intralesional injection of a sclerosant, and application of continuous negative pressure. Partialresection may be effective only in patients with organized hematoma.
참고문헌 (27)
- Guinto G, "Orbital lymphangiomas", World Neurosurg, pp.708~709 (2014)
- Rootman J, "Orbital-adnexal lymphangiomas: a spectrum of hemodynamically isolated vascular hamartomas", Ophthalmology, 93, pp.1558~1570 (1986)
- Russin JJ, "Surgical management, outcomes, and recurrence rate of orbital lymphangiomas", J Clin Neurosci, 22, pp.877~882 (2015)
- 이가현, "Successful Treatment of Orbital Lymphangioma with Intralesional Bleomycin and Application of Continuous Negative Pressure", Korean Journal of Ophthalmology, 29(1), pp.70~72 (2015), 대한안과학회
- Saha K, "Orbital lymphangiomas: a review of management strategies", Curr Opin Ophthalmol, 23, pp.433~438 (2012)
- Boulos PR, "Intralesional injection of Tisseel fibrin glue for resection of lymphangiomas and other thin-walled orbital cysts", Ophthal Plast Reconstr Surg, 21, pp.171~176 (2005)
- Gandhi NG, "Sildenafil for pediatric orbital lymphangioma", JAMA Ophthalmol, 131, pp.1228~1230 (2013)
- Tunc M, "Orbital lymphangioma: an analysis of 26 patients", Br J Ophthalmol, 83, pp.76~80 (1999)
- Jastrzebski A, "Isolated conjunctival lymphangioma", Can J Ophthalmol, 46, pp.369~370 (2011)
- Haik BG, "Magnetic resonance imaging of orbital lymphangiomas", Am J Ophthalmol, 103, pp.724~725 (1987)
- Kazim M, "Orbital lymphangioma: correlation of magnetic resonance images and intraoperative findings", Ophthalmology, 99, pp.1588~1594 (1992)
- Bisdorff A, "Intracranial vascular anomalies in patients with periorbital lymphatic and lymphaticovenous malformations", AJNR Am J Neuroradiol, 28, pp.335~341 (2007)
- Bond JB, "Magnetic resonance imaging of orbital lymphangioma with and without gadolinium contrast enhancement", Ophthalmology, 99, pp.1318~1324 (1992)
- Graeb DA, "Orbital lymphangiomas: clinical, radiologic, and pathologic characteristics", Radiology, 175, pp.417~421 (1990)
- Harris GJ, "An analysis of thirty cases of orbital lymphangioma: pathophysiologic considerations and management recommendations", Ophthalmology, 97, pp.1583~1592 (1990)
- Wilson ME, "Conservative management of childhood orbital lymphangioma", Ophthalmology, 96, pp.484~489 (1989)
- Wiegand S, "Sclerotherapy of lymphangiomas of the head and neck", Head Neck, 33, pp.1649~1655 (2011)
- Gochi A, "The prognostic advantage of preoperative intratumoral injection of OK-432for gastric cancer patients", Br J Cancer, 84, pp.443~451 (2001)
- Katano M, "The past, the present and future of the OK-432 therapy for patients with malignant effusions", Anticancer Res, 18, pp.3917~3925 (1998)
- Giguere CM, "Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial", Arch Otolaryngol Head Neck Surg, 128, pp.1137~1144 (2002)
- Suzuki Y, "Management of orbital lymphangioma using intralesional injection of OK-432", Br J Ophthalmol, 84, pp.614~617 (2000)
- Yoon JS, "Intralesional injection of OK-432 for vision-threatening orbital lymphangioma", Arch Clin Exp Ophthalmol, 245, pp.1031~1035 (2007)
- Saitta P, "Bleomycin in dermatology:a review of intralesional applications", Dermatol Surg, 34, pp.1299~1313 (2008)
- Muir T, "Intralesional bleomycin injection (IBI) treatment for haemangiomas and congenital vascular malformations", Pediatr Surg Int, 19, pp.766~773 (2004)
- Gooding C, "Intralesional bleomycin: a potential treatment for refractory orbital lymphangiomas", Ophthal Plast Reconstr Surg, 30, pp.e65~e67 (2014)
- Swetman GL, "Sildenafil for severe lymphatic malformations", N Engl J Med, 366, pp.384~386 (2012)
- Portnow LH, "Fractionated radiotherapy in the management of benign vascular tumors", Am J Clin Oncol, 35, pp.557~561 (2012)