Effect of Cataract Grade according to Wide-Field Fundus Images on Measurement of Macular Thickness in Cataract Patients
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: To investigate the effects of cataract grade based on wide-field fundus imaging on macular thickness measured by spectral domain optical coherence tomography (SD-OCT) and its signal-to-noise ratio (SNR). Methods: Two hundred cataract patients (200 eyes) with preoperative measurements by wide-field fundus imaging and macular SD-OCT were enrolled. Cataract severity was graded from 1 to 4 according to the degree of macular obscuring by cataract artifact in fundus photo images. Cataract grade based on wide-field fundus image, the Lens Opacity Classification System III, macular thickness, and SD-OCT SNR were compared. All SD-OCT B-scan images were evaluated to detect errors in retinal layer segmentation. Results: Cataract grade based on wide-field fundus imaging was positively correlated with grade of posterior subcapsular cataracts (rho = 0.486, p < 0.001), but not with nuclear opalescence or cortical cataract using the Lens Opacity Classification System III. Cataract grade was negatively correlated with total macular thickness (rho = -0.509, p < 0.001) and SD-OCT SNR (rho = -0.568, p < 0.001). SD-OCT SNR was positively correlated with total macular thickness (rho = 0.571, p < 0.001). Of 200 eyes, 97 (48.5%) had segmentation errors on SD-OCT. As cataract grade increased and SD-OCT SNR decreased, the percentage of eyes with segmentation errors on SD-OCT increased. All measurements of macular thickness in eyes without segmentation errors were significantly greater than those of eyes with segmentation errors. Conclusions: Posterior subcapsular cataracts had profound effects on cataract grade based on wide-field fundus imaging. As cataract grade based on wide-field fundus image increased, macular thickness tended to be underestimated due to segmentation errors in SD-OCT images. Segmentation errors in SD-OCT should be considered when evaluating macular thickness in eyes with cataracts.
Abstract
Purpose: To investigate the effects of cataract grade based on wide-field fundus imaging on macular thickness measured by spectral domain optical coherence tomography (SD-OCT) and its signal-to-noise ratio (SNR). Methods: Two hundred cataract patients (200 eyes) with preoperative measurements by wide-field fundus imaging and macular SD-OCT were enrolled. Cataract severity was graded from 1 to 4 according to the degree of macular obscuring by cataract artifact in fundus photo images. Cataract grade based on wide-field fundus image, the Lens Opacity Classification System III, macular thickness, and SD-OCT SNR were compared. All SD-OCT B-scan images were evaluated to detect errors in retinal layer segmentation. Results: Cataract grade based on wide-field fundus imaging was positively correlated with grade of posterior subcapsular cataracts (rho = 0.486, p < 0.001), but not with nuclear opalescence or cortical cataract using the Lens Opacity Classification System III. Cataract grade was negatively correlated with total macular thickness (rho = -0.509, p < 0.001) and SD-OCT SNR (rho = -0.568, p < 0.001). SD-OCT SNR was positively correlated with total macular thickness (rho = 0.571, p < 0.001). Of 200 eyes, 97 (48.5%) had segmentation errors on SD-OCT. As cataract grade increased and SD-OCT SNR decreased, the percentage of eyes with segmentation errors on SD-OCT increased. All measurements of macular thickness in eyes without segmentation errors were significantly greater than those of eyes with segmentation errors. Conclusions: Posterior subcapsular cataracts had profound effects on cataract grade based on wide-field fundus imaging. As cataract grade based on wide-field fundus image increased, macular thickness tended to be underestimated due to segmentation errors in SD-OCT images. Segmentation errors in SD-OCT should be considered when evaluating macular thickness in eyes with cataracts.
참고문헌 (30)
- Fujimoto JG, "Optical biopsy and imaging using optical coherence tomography", Nat Med, 1, pp.970~972 (1995)[DOI]
- Leung CK, "Diagnosing glaucoma progression with optical coherence tomography", Curr Opin Ophthalmol, 25, pp.104~111 (2014)[DOI]
- Xu G, "Retinal nerve fiber layer progression in glaucoma: a comparison between retinal nerve fiber layer thickness and retardance", Ophthalmology, 120, pp.2493~2500 (2013)[DOI]
- Savastano MC, "Differential vulnerability of retinal layers to early age-related macular degeneration: evidence by SD-OCT segmentation analysis", Invest Ophthalmol Vis Sci, 55, pp.560~566 (2014)[DOI]
- Belair ML, "Incidence of cystoid macular edema after cataract surgery in patients with and without uveitis using optical coherence tomography", Am J Ophthalmol, 148, pp.128~135 (2009)[DOI]
- Lee DW, "Effect of media opacity on retinal nerve fiber layer thickness measurements by optical coherence tomography", J Ophthalmic Vis Res, 5, pp.151~157 (2010)
- Mastropasqua L, "Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography in silicone oil-filled eyes", Ophthalmologica, 215, pp.91~96 (2001)[DOI]
- El-Ashry M, "The effect of phacoemulsification cataract surgery on the measurement of retinal nerve fiber layer thickness using optical coherence tomography", Curr Eye Res, 31, pp.409~413 (2006)[DOI]
- Kim NR, "Influence of cataract on time domain and spectral domain optical coherence tomography retinal nerve fiber layer measurements", J Glaucoma, 21, pp.116~122 (2012)
- Kok PH, "The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography", Acta Ophthalmol, 91, pp.418~424 (2013)[DOI]
- Nakatani Y, "Effect of cataract and its removal on ganglion cell complex thickness and peripapillary retinal nerve fiber layer thickness measurements by fourier-domain optical coherence tomography", J Glaucoma, 22, pp.447~455 (2013)[DOI]
- von Jagow B, "Macular thickness after uneventful cataract surgery determined by optical coherence tomography", Graefes Arch Clin Exp Ophthalmol, 245, pp.1765~1771 (2007)[DOI]
- van Velthoven ME, "Influence of cataract on optical coherence tomography image quality and retinal thickness", Br J Ophthalmol, 90, pp.1259~1262 (2006)[DOI]
- Friberg TR, "Ultrawide angle fluorescein angiographic imaging: a comparison to conventional digital acquisition systems", Ophthalmic Surg Lasers Imaging, 39, pp.304~311 (2008)[DOI]
- Wessel MM, "Ultra-wide-field angiography improves the detection and classification of diabetic retinopathy", Retina, 32, pp.785~791 (2012)[DOI]
- Mudvari SS, "Ultra-wide-field imaging for cytomegalovirus retinitis", Ophthalmic Surg Lasers Imaging, 41, pp.311~315 (2010)[DOI]
- Silva PS, "Peripheral lesions identified by mydriatic ultrawide field imaging: distribution and potential impact on diabetic retinopathy severity", Ophthalmology, 120, pp.2587~2595 (2013)[DOI]
- Inoue M, "Wide-field fundus imaging using the Optos Optomap and a disposable eyelid speculum", JAMA Ophthalmol, 131, pp.226~ (2013)[DOI]
- Chylack LT Jr, "The Lens Opacities Classification System III: the Longitudinal Study of Cataract Study Group", Arch Ophthalmol, 111, pp.831~836 (1993)[DOI]
- 최한뉘, "부분결합레이저간섭계로 안구생체계측 가능 여부에 따른 백내장수술의 합병증 발생빈도", 대한안과학회지, 58(7), pp.804~810 (2017), 대한안과학회
- Domalpally A, "Quantitative analysis of the Stratus optical coherence tomography fast macular thickness map reports", Indian J Ophthalmol, 58, pp.131~136 (2010)[DOI]
- Balasubramanian M, "Effect of image quality on tissue thickness measurements obtained with spectral domain-optical coherence tomography", Opt Express, 17, pp.4019~4036 (2009)[DOI]
- Chua BE, "Effects of cataract type and location on visual function: the Blue Mountains Eye Study", Eye (Lond), 18, pp.765~772 (2004)[DOI]
- Lobo CL, "Macular alterations after small-incision cataract surgery", J Cataract Refract Surg, 30, pp.752~760 (2004)[DOI]
- McColgin AZ, "Control of intraocular inflammation associated with cataract surgery", Curr Opin Ophthalmol, 11, pp.3~6 (2000)[DOI]
- Akcay BI, "Quantitative analysis of macular thickness following uneventful and complicated cataract surgery", Clin Ophthalmol, 6, pp.1507~1511 (2012)
- Moghimi S, "Topical latanoprost does not cause macular thickening after uncomplicated cataract surgery", J Ophthalmic Vis Res, 7, pp.289~294 (2012)
- Sari ES, "The effect of intracameral anesthesia on macular thickness and ganglion cell-inner plexiform layer thickness after uneventful phacoemulsification surgery: prospective and randomized controlled trial", Graefes Arch Clin Exp Ophthalmol, 252, pp.433~439 (2014)[DOI]
- Falcao MS, "Choroidal and macular thickness changes induced by cataract surgery", Clin Ophthalmol, 8, pp.55~60 (2014)
- Cagini C, "Macular thickness measured by optical coherence tomography in a healthy population before and after uncomplicated cataract phacoemulsification surgery", Curr Eye Res, 34, pp.1036~1041 (2009)[DOI]