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Additive Role of Optical Coherence Tomography Angiography Vessel Density Measurements in Glaucoma Diagnoses

성경림|권준기|권혜지
대한안과학회 (The Korean Ophthalmological Society)|2019.08|Korean Journal of Ophthalmology|제33권 제4호|pp. 315-325|DOI 10.3341/kjo.2019.0016

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키워드

GlaucomaDiagnostic techniques and proceduresOptical coherence tomography angiography
주제분류안과학

초록

Purpose: This study compared the glaucoma diagnostic abilities of optical coherence tomography (OCT) andoptical coherence tomography angiography (OCTA). In addition, the possibility of enhancing diagnostic capabilityby combining the two modalities was investigated. Methods: A total of 131 healthy eyes and 113 glaucomatous eyes were imaged by both OCT and OCTA. InOCT, glaucoma was defined as when the color of the superior or inferior quadrant of the peripapillary retinalnerve fiber layer thickness map was yellow (borderline, <5%) or red (outside normal limits, <1%). In OCTA,glaucoma was determined using the cut-off value of the superior or inferior peripapillary vessel density, calculatedafter receiver operating characteristic curve analysis. Sensitivity and specificity were determined by OCTalone, by OCTA alone, or by OCT and OCTA combined. Results: The sensitivity of OCT (86.7%) was better than that of OCTA (74.3%), whereas the specificity of OCTA(87.0%) was better than that of OCT (67.9%). When these two modalities were combined, both sensitivity andspecificity were enhanced (90.3% and 92.4%, respectively). Among the 131 eyes, 32 were misdiagnosed asglaucomatous by OCT but accurately diagnosed as normal by OCTA. These eyes were myopic, with a longeraxial length and a thinner and temporally displaced peak of peripapillary retinal nerve fiber layer thickness,causing the false positive result in OCT. Conclusions: When OCTA was combined with OCT, the specificity of glaucoma diagnoses were enhanced. OCTA may compensate for the shortcomings of OCT in the diagnosis of glaucoma.

Abstract

Purpose: This study compared the glaucoma diagnostic abilities of optical coherence tomography (OCT) andoptical coherence tomography angiography (OCTA). In addition, the possibility of enhancing diagnostic capabilityby combining the two modalities was investigated. Methods: A total of 131 healthy eyes and 113 glaucomatous eyes were imaged by both OCT and OCTA. InOCT, glaucoma was defined as when the color of the superior or inferior quadrant of the peripapillary retinalnerve fiber layer thickness map was yellow (borderline, <5%) or red (outside normal limits, <1%). In OCTA,glaucoma was determined using the cut-off value of the superior or inferior peripapillary vessel density, calculatedafter receiver operating characteristic curve analysis. Sensitivity and specificity were determined by OCTalone, by OCTA alone, or by OCT and OCTA combined. Results: The sensitivity of OCT (86.7%) was better than that of OCTA (74.3%), whereas the specificity of OCTA(87.0%) was better than that of OCT (67.9%). When these two modalities were combined, both sensitivity andspecificity were enhanced (90.3% and 92.4%, respectively). Among the 131 eyes, 32 were misdiagnosed asglaucomatous by OCT but accurately diagnosed as normal by OCTA. These eyes were myopic, with a longeraxial length and a thinner and temporally displaced peak of peripapillary retinal nerve fiber layer thickness,causing the false positive result in OCT. Conclusions: When OCTA was combined with OCT, the specificity of glaucoma diagnoses were enhanced. OCTA may compensate for the shortcomings of OCT in the diagnosis of glaucoma.

참고문헌 (33)

  1. Weinreb RN, "The pathophysiology and treatment of glaucoma : a review", JAMA, 311, pp.1901~1911 (2014)
  2. Kountouras J, "Primary open-angle glaucoma : pathophysiology and treatment", Lancet, 364, pp.1311~1312 (2004)
  3. Gemenetzi M, "Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment", Eye (Lond), 26, pp.355~369 (2012)
  4. Jia Y, "Quantitative OCT angiography of optic nerve head blood flow", Biomed Opt Express, 3, pp.3127~3137 (2012)
  5. Jia Y, "Optical coherence tomography angiography of optic disc perfusion in glaucoma", Ophthalmology, 121, pp.1322~1332 (2014)
  6. Leveque PM, "Optic disc vascularization in glaucoma : value of spectral-domain optical coherence tomography angiography", J Ophthalmol, 2016, pp.6956717~ (2016)
  7. Li J, "Reproducibility of perfusion parameters of optic disc and macula in rhesus monkeys by optical coherence tomography angiography", Chin Med J(Engl), 129, pp.1087~1090 (2016)
  8. Liu L, "Optical coherence tomography angiography of the peripapillary retina in glaucoma", JAMA Ophthalmol, 133, pp.1045~1052 (2015)
  9. Mammo Z, "Quantitative optical coherence tomography angiography of radial peripapillary capillaries in glaucoma, glaucoma suspect, and normal eyes", Am J Ophthalmol, 170, pp.41~49 (2016)
  10. Mansoori T, "Measurement of radial peripapillary capillary density in the normal human retina using optical coherence tomography angiography", J Glaucoma, 26, pp.241~246 (2017)
  11. Mo S, "Visualization of radial peripapillary capillaries using optical coherence tomography angiography : the effect of image averaging", PLoS One, 12, pp.e0169385~ (2017)
  12. Rao HL, "Diagnostic ability of peripapillary vessel density measurements of optical coherence tomography angiography in primary open-angle and angle-closure glaucoma", Br J Ophthalmol, 101, pp.1066~1070 (2017)
  13. Yu J, "Macular perfusion in healthy Chinese : an optical coherence tomography angiogram study", Invest Ophthalmol Vis Sci, 56, pp.3212~3217 (2015)
  14. Bojikian KD, "Optic disc perfusion in primary open angle and normal tension glaucoma eyes using optical coherence tomography-based microangiography", PLoS One, 11, pp.e0154691~ (2016)
  15. Wang X, "Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma : an optical coherence tomography angiography study", Graefes Arch Clin Exp Ophthalmol, 253, pp.1557~1564 (2015)
  16. Kwon J, "Glaucoma diagnostic capabilities of foveal avascular zone parameters using optical coherence tomography angiography according to visual field defect location", J Glaucoma, 26, pp.1120~1129 (2017)
  17. Rao HL, "regional comparisons of optical coherence tomography angiography vessel density in primary open-angle glaucoma", Am J Ophthalmol, 171, pp.75~83 (2016)
  18. Rao HL, "A comparison of the diagnostic ability of vessel density and structural measurements of optical coherence tomography in primary open angle glaucoma", PLoS One, 12, pp.e0173930~ (2017)
  19. Sung KR, "Comparison of retinal nerve fiber layer thickness measured by Cirrus HD and Stratus optical coherence tomography", Ophthalmology, 116, pp.1264~1270 (2009)
  20. Sung KR, "Imaging of the retinal nerve fibre layer with spectral domain optical coherence tomography for glaucoma diagnosis", Br J Ophthalmol, 95, pp.909~914 (2011)
  21. Asrani S, "Artifacts in spectral-domain optical coherence tomography measurements in glaucoma", JAMA Ophthalmol, 132, pp.396~402 (2014)
  22. Aykut V, "Influence of axial length on peripapillary retinal nerve fiber layer thickness in children : a study by RTVue spectral-domain optical coherence tomography", Curr Eye Res, 38, pp.1241~1247 (2013)
  23. Dhami A, "Correlation of retinal nerve fiber layer thickness and axial length on Fourier domain optical coherence tomography", J Clin Diagn Res, 10, pp.NC15~NC17 (2016)
  24. Hirasawa K, "Determination of axial length requiring adjustment of measured circumpapillary retinal nerve fiber layer thickness for ocular magnification", PLoS One, 9, pp.e107553~ (2014)
  25. Oner V, "Effect of axial length on retinal nerve fiber layer thickness in children", Eur J Ophthalmol, 24, pp.265~272 (2014)
  26. Yamashita T, "Correlations between retinal nerve fiber layer thickness and axial length, peripapillary retinal tilt, optic disc size, and retinal artery position in healthy eyes", J Glaucoma, 26, pp.34~40 (2017)
  27. Suh MH, "Deep retinal layer microvasculature dropout detected by the optical coherence tomography angiography in glaucoma", Ophthalmology, 123, pp.2509~2518 (2016)
  28. Garway-Heath DF, "Mapping the visual field to the optic disc in normal tension glaucoma eyes", Ophthalmology, 107, pp.1809~1815 (2000)
  29. Chung JK, "Glaucoma diagnostic ability of the optical coherence tomography angiography vessel density parameters", Curr Eye Res, 42, pp.1458~1467 (2017)
  30. Hwang YH, "Characteristics of peripapillary retinal nerve fiber layer thickness in eyes with myopic optic disc tilt and rotation", J Glaucoma, 21, pp.394~400 (2012)
  31. Hwang YH, "Myopic optic disc tilt and the characteristics of peripapillary retinal nerve fiber layer thickness measured by spectral-domain optical coherence tomography", J Glaucoma, 21, pp.260~265 (2012)
  32. Mauschitz MM, "Systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness measurements in the European eye epidemiology(E3)population", Ophthalmology, 125, pp.1526~1536 (2018)
  33. Lee EJ, "OCT angiography of the peripapillary retina in primary open-angle glaucoma", Invest Ophthalmol Vis Sci, 57, pp.6265~6270 (2016)

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