Comparison between 0.1% Nepafenac and 1% Prednisolone Eye Drop in Postoperative Management Following Micro-incisional Cataract Surgery
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Purpose: To compare the efficacy of 0.1% nepafenac and 1% prednisolone acetate eye drop in postoperative inflammationcontrol in micro-incisional cataract surgery. Methods: We conducted a prospective, randomized, comparative, single-blind study. All the patients underwent temporal2.2-mm micro-incisional cataract surgery. They were randomized into two groups (group A and B). Group A received 0.1%nepafenac eye drops 4 times/day for 4 weeks and group B received 1% prednisolone acetate eye drops in tapering doses for4 weeks after surgery. Both the groups received moxifloxacin 0.5% eye drops 4 times/day for 2 weeks. Patients were examinedon 1st, 7th, and 30th postoperative days and parameters of postoperative inflammation were evaluated and noted ateach visit. Results: A total of 200 patients were enrolled in the study. However, five patients lost to follow up, group A had 97 and groupB had 98 patients respectively. Results were statistically insignificant in terms of the difference in lid edema, conjunctival congestion,corneal edema, anterior chamber cells and flare between the two groups with p-values >0.05 for each parameter ateach visit. However, the difference in mean central macular thickness between the groups was significant (205.713 ± 17.14 vs. 220.984 ± 32.83 in group A and B, respectively, p ≤ 0.001) at 1 month. Also, the mean pain score was significantly lower (p =0.018) in the nepafenac group at day 7 of surgery. Conclusions: Nepafenac is equally effective and non-inferior to prednisolone acetate in suppression and prevention of inflammationin postoperative period.
Abstract
Purpose: To compare the efficacy of 0.1% nepafenac and 1% prednisolone acetate eye drop in postoperative inflammationcontrol in micro-incisional cataract surgery. Methods: We conducted a prospective, randomized, comparative, single-blind study. All the patients underwent temporal2.2-mm micro-incisional cataract surgery. They were randomized into two groups (group A and B). Group A received 0.1%nepafenac eye drops 4 times/day for 4 weeks and group B received 1% prednisolone acetate eye drops in tapering doses for4 weeks after surgery. Both the groups received moxifloxacin 0.5% eye drops 4 times/day for 2 weeks. Patients were examinedon 1st, 7th, and 30th postoperative days and parameters of postoperative inflammation were evaluated and noted ateach visit. Results: A total of 200 patients were enrolled in the study. However, five patients lost to follow up, group A had 97 and groupB had 98 patients respectively. Results were statistically insignificant in terms of the difference in lid edema, conjunctival congestion,corneal edema, anterior chamber cells and flare between the two groups with p-values >0.05 for each parameter ateach visit. However, the difference in mean central macular thickness between the groups was significant (205.713 ± 17.14 vs. 220.984 ± 32.83 in group A and B, respectively, p ≤ 0.001) at 1 month. Also, the mean pain score was significantly lower (p =0.018) in the nepafenac group at day 7 of surgery. Conclusions: Nepafenac is equally effective and non-inferior to prednisolone acetate in suppression and prevention of inflammationin postoperative period.
참고문헌 (39)
- El-Harazi SM, "Control of intra-ocular inflammation associated with cataract surgery", Curr Opin Ophthalmol, 12, pp.4~8 (2001)
- Kato K, "Management of postoperative inflammation and dry eye after cataract surgery", Cornea, 38(Suppl 1), pp.S25~S33 (2019)
- Bardoloi N, "Efficacy and safety of dropless cataract surgery", Indian J Ophthalmol, 68, pp.1081~1085 (2020)
- Sahu S, "Effect of topical ketorolac 0.4%, nepafenac 0.1%, and bromfenac 0.09% on postoperative inflammation using laser flare photometry in patients having phacoemulsification", J Cataract Refract Surg, 41, pp.2043~2048 (2015)
- Miyake K, "Nepafenac 0.1%versus fluorometholone 0.1% for preventing cystoid macular edema after cataract surgery", J Cataract Refract Surg, 37, pp.1581~1588 (2011)
- Nagpal M, "Topical nepafenac 0.1% alone versus prednisolone acetate 1% as postoperative anti-inflammatory agents in small gauge vitrectomy", Indian J Ophthalmol, 62, pp.606~609 (2014)
- DeCroos FC, "Perioperative antibiotics and anti-inf lammatory agents in cataract surgery", Curr Opin Ophthalmol, 19, pp.22~26 (2008)
- Heier JS, "Ketorolac versus prednisolone versus combination therapy in the treatment of acute pseudophakic cystoid macular edema", Ophthalmology, 107, pp.2034~2038 (2000)
- Chinchurreta Capote AM, "Comparative study of the efficacy and safety of bromfenac, nepafenac and diclofenac sodium for the prevention of cystoid macular edema after phacoemulsification", Int J Ophthalmol, 11, pp.1210~1216 (2018)
- Yuksel B, "Topical nepafenac for prevention of post-cataract surgery macular edema in diabetic patients: patient selection and perspectives", Clin Ophthalmol, 11, pp.2183~2190 (2017)
- Chylack LT Jr, "The lens opacities classification system III. The longitudinal study of cataract study group", Arch Ophthalmol, 111, pp.831~836 (1993)
- Vasavada AR, "Stop, chop, chop, and stuff", J Cataract Refract Surg, 22, pp.526~529 (1996)
- Vasavada A, "Step-by-step chop in situ and separation of very dense cataracts", J Cataract Refract Surg, 24, pp.156~159 (1998)
- Bardoloi N, "Pure phaco:phacoemulsification without ophthalmic viscosurgical devices", J Cataract Refract Surg, 46, pp.174~178 (2020)
- Jabs DA, "Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop", Am J Ophthalmol, 140, pp.509~516 (2005)
- Fu C, "Bimanual microincision cataract surgery versus coaxial microincision cataract surgery:a meta-analysis of randomized controlled trials and cohort studies", J Ophthalmol, 2017, pp.3737603~ (2017)
- Shentu X, "Coaxial microincision cataract surgery versus standard coaxial small-incision cataract surgery: a meta-analysis of randomized controlled trials", PLoS One, 11, pp.e0146676~ (2016)
- Luo L, "Clinical evaluation of three incision size-dependent phacoemulsification systems", Am J Ophthalmol, 153 (2012)
- Can I, "Coaxial, microcoaxial, and biaxial microincision cataract surgery: prospective comparative study", J Cataract Refract Surg, 36, pp.740~746 (2010)
- Wilczynski M, "Comparison of surgically induced astigmatism after coaxial phacoemulsification through 1.8 mm microincision and bimanual phacoemulsification through 1.7 mm microincision", J Cataract Refract Surg, 35, pp.1563~1569 (2009)
- Alio JL, "Visual outcome of microincision cataract surgery with implantation of an Acri. Smart lens", J Cataract Refract Surg, 31, pp.1549~1556 (2005)
- Solomon KD, "Topical ketorolac tromethamine 0.5% ophthalmic solution in ocular inf lammation after cataract surgery", Ophthalmology, 108, pp.331~337 (2001)
- Lane SS, "Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery", J Cataract Refract Surg, 33, pp.53~58 (2007)
- Ke TL, "Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers", Inflammation, 24, pp.371~384 (2000)
- Walters T, "In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac", J Cataract Refract Surg, 33, pp.1539~1545 (2007)
- Simone JN, "Effects of anti-inflammatory drugs following cataract extraction", Curr Opin Ophthalmol, 12, pp.63~67 (2001)
- Keates RH, "Clinical trial of flurbiprofen to maintain pupillary dilation during cataract surgery", Ann Ophthalmol, 16, pp.919~921 (1984)
- Gwon A, "Ocufen (flurbiprofen) in the treatment of ocular pain after radial keratotomy", CLAO J, 20, pp.131~138 (1994)
- Stark WJ, "Reduction of pupillary constriction during cataract surgery using suprofen", Arch Ophthalmol, 104, pp.364~366 (1986)
- Keates RH, "The effect of topical indomethacin ophthalmic solution in maintaining mydriasis during cataract surgery", Ann Ophthalmol, 16, pp.1116~1121 (1984)
- Koay P, "The emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology", Br J Ophthalmol, 80, pp.480~485 (1996)
- Arshinoff S, "Use of topical nonsteroidal anti-inflammatory drugs in excimer laser photorefractive keratectomy", J Cataract Refract Surg, 20(Suppl), pp.216~222 (1994)
- Bucci FA Jr, "Prostaglandin E2 inhibition of ketorolac 0.45%, bromfenac 0.09%, and nepafenac 0.1% in patients undergoing phacoemulsif ication", Adv Ther, 28, pp.1089~1095 (2011)
- Miyake K, "Comparison of diclofenac and fluorometholone in preventing cystoid macular edema after small incision cataract surgery: a multicentered prospective trial", Jpn J Ophthalmol, 44, pp.58~67 (2000)
- Naithani P, "Role of topical nepafenac in prevention and treatment of macular edema after vitreoretinal surgery", Retina, 32, pp.250~255 (2012)
- Flach AJ, "The effect of ketorolac tromethamine in reducing postoperative inflammation: double-mask parallel comparison with dexamethasone", Ann Ophthalmol, 21, pp.407~411 (1989)
- Simone JN, "Comparison of the efficacy and safety of ketorolac tromethamine 0.5% and prednisolone acetate 1% after cataract surgery", J Cataract Refract Surg, 25, pp.699~704 (1999)
- Brennan KM, "A comparison of topical non-steroidal anti-inflammatory drugs to steroids for control of post cataract inflammation", Insight, 18, pp.8~9 (1993)
- Gaynes BI, "Topical nonsteroidal anti-inflammatory drugs for ophthalmic use: a safety review", Drug Saf, 25, pp.233~250 (2002)