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A Case of Oculomotor Nerve Palsy and Choroidal Tuberculous Granuloma Associated with Tuberculous Meningoencephalitis

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We report a rare case of oculomotor nerve palsy and choroidal tuberculous granuloma associated with tuberculous meningoencephalitis. A 15-year-old male visited our hospital for an acute drop of the left eyelid and diplopia. He has been on anti-tuberculous drugs (isoniazid, rifampin) for 1 year for his tuberculous encephalitis. A neurological examination revealed a conscious clear patient with isolated left oculomotor nerve palsy, which manifested as ptosis, and a fundus examination revealed choroidal tuberculoma. Other anti-tuberculous drugs (pyrazinamide, ethambutol) and a steroid (dexamethasone) were added. After 3 months on this medication, ptosis of the left upper eyelid improved and the choroidal tuberculoma decreasedin size, but a right homonymous visual field defect remained. When a patient with tuberculous meningitis presents with abrupt onset oculomotor nerve palsy, rapid re-diagnosis should be undertaken and proper treatment initiated, because the prognosis is critically dependent on the timing of adequate treatment.

Abstract

We report a rare case of oculomotor nerve palsy and choroidal tuberculous granuloma associated with tuberculous meningoencephalitis. A 15-year-old male visited our hospital for an acute drop of the left eyelid and diplopia. He has been on anti-tuberculous drugs (isoniazid, rifampin) for 1 year for his tuberculous encephalitis. A neurological examination revealed a conscious clear patient with isolated left oculomotor nerve palsy, which manifested as ptosis, and a fundus examination revealed choroidal tuberculoma. Other anti-tuberculous drugs (pyrazinamide, ethambutol) and a steroid (dexamethasone) were added. After 3 months on this medication, ptosis of the left upper eyelid improved and the choroidal tuberculoma decreasedin size, but a right homonymous visual field defect remained. When a patient with tuberculous meningitis presents with abrupt onset oculomotor nerve palsy, rapid re-diagnosis should be undertaken and proper treatment initiated, because the prognosis is critically dependent on the timing of adequate treatment.

참고문헌 (6)

  1. Desai HG, "Ophthalmological aspects of tuberculous meningitis", J Indian Med Assoc, 49, pp.429~32 (1967)
  2. Johnson RT, "Current therapy in neurologic disease, 7th", pp.158~60 (2005), Philadelphia: mosby
  3. Milla E, "Bilateral optic papillitis following mycoplasma pneumoniae pneumonia", Opthalmologica, 212, pp.344~6 (1998)
  4. Kocen RS, "Neurological complications of tuberculosis: some unusual manifestation", Q J Med, 39, pp.17~30 (1970)
  5. Levecq LJ, "Solitary choroidal tuberculoma in an immunocompetent patient", Arch Ophthalmol, 123, pp.864~6 (2005)
  6. Amitava AK, "Neuro-ophthalmic features in pediatric tubercular meningoencephalitis", J Pediatr Ophthalmol Strabismus, 38, pp.229~34 (2001)

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