Clinical Characteristics of Juvenile-onset Open Angle Glaucoma
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Purpose: To demonstrate the clinical characteristics of juvenile-onset open angle glaucoma (JOAG) and to evaluatethe prognostic factors for visual field (VF) progression in eyes with JOAG. Methods: The medical records of 125 eyes of 72 patients with JOAG were analyzed retrospectively. At leastfour reliable VF tests were required to determine the VF progression, and the progression was defined usingthe modified Anderson criteria. Comparisons in clinical manifestations among groups were performed usingindependent t-test, and generalized estimating equations were also conducted. Results: The mean follow-up duration was 94.4 ± 50.5 months. Patients with JOAG showed a male preponderance(64%), myopia (-4.99 ± 4.01 diopters) and a severe elevation of intraocular pressure (35.6 ± 10.8 mmHg). Forty-two JOAG patients (58%) had complained of symptoms associated with vision and pain; however, onethirdpresented with no definite symptoms. Fifty-seven patients were diagnosed with JOAG in both eyes, andthey were significantly older (p = 0.039) and had a greater family history (p = 0.035) than patients with unilateralJOAG. The progression group exhibited a significantly higher intraocular pressure at the last visit (p = 0.023)than the non-progression group. Conclusions: Because patients with considerable JOAG had no definite symptoms, periodic eye examinationsare needed. To prevent the VF’s progression, JOAG patients may require more careful management of intraocularpressure.
Abstract
Purpose: To demonstrate the clinical characteristics of juvenile-onset open angle glaucoma (JOAG) and to evaluatethe prognostic factors for visual field (VF) progression in eyes with JOAG. Methods: The medical records of 125 eyes of 72 patients with JOAG were analyzed retrospectively. At leastfour reliable VF tests were required to determine the VF progression, and the progression was defined usingthe modified Anderson criteria. Comparisons in clinical manifestations among groups were performed usingindependent t-test, and generalized estimating equations were also conducted. Results: The mean follow-up duration was 94.4 ± 50.5 months. Patients with JOAG showed a male preponderance(64%), myopia (-4.99 ± 4.01 diopters) and a severe elevation of intraocular pressure (35.6 ± 10.8 mmHg). Forty-two JOAG patients (58%) had complained of symptoms associated with vision and pain; however, onethirdpresented with no definite symptoms. Fifty-seven patients were diagnosed with JOAG in both eyes, andthey were significantly older (p = 0.039) and had a greater family history (p = 0.035) than patients with unilateralJOAG. The progression group exhibited a significantly higher intraocular pressure at the last visit (p = 0.023)than the non-progression group. Conclusions: Because patients with considerable JOAG had no definite symptoms, periodic eye examinationsare needed. To prevent the VF’s progression, JOAG patients may require more careful management of intraocularpressure.
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