Ophthalmologic Features of Lennox-Gastaut Syndrome
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Purpose: To describe the characteristics and frequency of ophthalmologic findings in patients with Lennox-Gastaut syndrome (LGS). Methods: The medical records of patients diagnosed with LGS at Seoul National University Children’s Hospitalfrom January 2004 to August 2014 were retrospectively reviewed. The records of 34 patients (mean age ±standard deviation, 2.66 ± 3.51 years; male, 58.8%) were reviewed. The primary measure was the incidenceof ophthalmologic manifestations. Results: Of the 34 patients, 88.2% had at least one ocular abnormality. Refractive error (52.9%) was the mostfrequently observed ophthalmologic manifestation in patients with LGS, followed by strabismus (32.4%), corticalvisual impairment (23.5%), and retinopathy of prematurity (8.8%). Among these cases, seven patientshad exotropia and three had esotropia. Conclusions: LGS is a childhood-onset epileptic encephalopathy with variable ophthalmologic manifestations,the most frequent being refractive errors. Patients with suspected LGS should be examined regularly becauseophthalmological features can change during their disease course.
Abstract
Purpose: To describe the characteristics and frequency of ophthalmologic findings in patients with Lennox-Gastaut syndrome (LGS). Methods: The medical records of patients diagnosed with LGS at Seoul National University Children’s Hospitalfrom January 2004 to August 2014 were retrospectively reviewed. The records of 34 patients (mean age ±standard deviation, 2.66 ± 3.51 years; male, 58.8%) were reviewed. The primary measure was the incidenceof ophthalmologic manifestations. Results: Of the 34 patients, 88.2% had at least one ocular abnormality. Refractive error (52.9%) was the mostfrequently observed ophthalmologic manifestation in patients with LGS, followed by strabismus (32.4%), corticalvisual impairment (23.5%), and retinopathy of prematurity (8.8%). Among these cases, seven patientshad exotropia and three had esotropia. Conclusions: LGS is a childhood-onset epileptic encephalopathy with variable ophthalmologic manifestations,the most frequent being refractive errors. Patients with suspected LGS should be examined regularly becauseophthalmological features can change during their disease course.
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