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제2형 과립각막이상증 이형접합자에서 치료레이저각막절제술 전후의 대비감도 변화

Contrast Sensitivity Changes after Phototherapeutic Keratectomy in Heterozygote Granular Corneal Dystrophy Type 2

김희영|최진석|김태환|안지선|김응권|서지형|문자윤
대한안과학회 (The Korean Ophthalmological Society)|2022.06|대한안과학회지 (Journal of The Korean Ophthalmological Society)|제63권 제6호|pp. 510-518|DOI 10.3341/jkos.2022.63.6.510

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키워드

GlareContrast sensitivityCorneal dystrophy Avellino typeKeratectomyVision tests
주제분류안과학

초록

목적: 대비감도란 배경 또는 인접 사물로부터 특정 물체의 상대적 밝기 차이를 감지하는 기능(능력)으로 다양한 환경에서의 시기능을평가할 수 있다. 제2형 과립각막이상증(granular corneal dystrophy type 2, GCD2)은 각막 기질의 혼탁으로 시기능의 저하를 일으킨다. 이에 본 저자들은 GCD2에서 치료레이저각막절제술(phototherapeutic keratectomy, PTK) 전후 대비감도를 비교하여, 치료 전후의 시기능을 비교하고자 하였다. 대상과 방법: 22명의 GCD2 이형접합자를 대상으로, PTK 전과 후의 시력과 대비감도를 측정하였다. 대비감도는 야간(3 cd/m2)과 주간(85 cd/m2) 조도에서 눈부심 0, 1, 2단계(glare [G]; G0, G1, G2), 공간주파수 1.5, 3, 6, 12, 18 cycles per degrees (cpd)에 대하여각각 검사하였다. 결과: 수술 후 1.5, 3 cpd에서 야간과 주간 조도 시, G0-2의 모든 눈부심 단계에서 대비감도의 향상을 보였다(p<0.05). 6 cpd에서는야간 시 G1, 주간 시 G0-2의 눈부심 단계에서 대비감도의 향상이 있었다(p<0.05). 반면 12, 18 cpd에서는 야간, 주간 조도 시 G0-2의모든 눈부심 단계에서 수술 전후의 대비감도 차이를 볼 수 없었다. 결론: GCD2 환자에서, PTK를 통해 대비감도가 크게 향상되었다. 각막혼탁으로 저하된 GCD2 환자의 시기능이 PTK로 인해 뚜렷이개선됨을 대비감도검사를 통해 확인하였다.

Abstract

Purpose: Contrast sensitivity, the ability to distinguish the relative difference in luminance of an object from its surrounding or adjacent objects, is a useful measure of visual function. In granular corneal dystrophy type 2 (GCD2), opacity of the corneal stroma causes deterioration in visual function. We compared the contrast sensitivity of GCD2 patients before and after phototherapeutic keratectomy (PTK) to evaluate the perioperative visual function in these patients. Methods: This study included 22 eyes of heterozygote GCD2 patients. The visual acuity and contrast sensitivity were measured before and after PTK. The contrast sensitivity was measured in mesopic and photopic background luminances, with glare (G) levels of 0-2 (G0, G1, and G2, respectively) and spatial frequencies at 1.5, 3, 6, 12, and 18 cycles per degree (cpd). Results: The contrast sensitivity increased after PTK at 1.5 and 3 cpd in mesopic and photopic conditions with G0-2 glare (p < 0.05). At 6 cpd, the contrast sensitivity increased in the mesopic condition with G1 glare, and in the photopic condition with G0-2 glare (p < 0.05). However, there was no change in contrast sensitivity at any glare level at 12 and 18 cpd after PTK. Conclusions: In GCD2 patients, the contrast sensitivity increased significantly after PTK. The vision of GCD2 patients, which is decreased due to corneal opacity, is improved after PTK.

참고문헌 (50)

  1. Richman J, "Contrast sensitivity basics and a critique of currently available tests", J Cataract Refract Surg, 39, pp.1100~1106 (2013)
  2. Pelli DG, "Measuring contrast sensitivity", Vision Res, 90, pp.10~14 (2013)
  3. Ginsburg AP, "Contrast sensitivity : determining the visual quality and function of cataract, intraocular lenses and refractive surgery", Curr Opin Ophthalmol, 17, pp.19~26 (2006)
  4. Vasavada VA, "Contrast sensitivity assessment in pediatric cataract surgery : comparison of preoperative and early postoperative outcomes", J Cataract Refract Surg, 40, pp.1862~1867 (2014)
  5. Ichhpujani P, "Contrast sensitivity and glaucoma", J Glaucoma, 29, pp.71~75 (2020)
  6. Faria BM, "Evaluating contrast sensitivity in age-related macular degeneration using a novel computer-based test, the spaeth", richman contrast sensitivity test, 2015, pp.35, 1465~1473
  7. Owsley C, "Contrast sensitivity, acuity, and the perception of 'real-world' targets", Br J Ophthalmol, 71, pp.791~796 (1987)
  8. Augustin VA, "Influence of corneal guttae and nuclear cataract on contrast sensitivity", Br J Ophthalmol, 105, pp.1365~1370 (2021)
  9. Bal T, "Influence of cataract morphology on straylight and contrast sensitivity and its relevance to fitness to drive", Ophthalmologica, 225, pp.105~111 (2011)
  10. Keane PA, "Effects of retinal morphology on contrast sensitivity and reading ability in neovascular age-related macular degeneration", Invest Ophthalmol Vis Sci, 51, pp.5431~5437 (2010)
  11. Hawkins AS, "Comparison of contrast sensitivity, visual acuity, and humphrey visual field testing in patients with glaucoma", J Glaucoma, 12, pp.134~138 (2003)
  12. Lahav K, "Reduced mesopic and photopic foveal contrast sensitivity in glaucoma", Arch Ophthalmol, 129, pp.16~22 (2011)
  13. Koh S, "The effect of ocular surface regularity on contrast sensitivity and straylight in dry eye", Invest Ophthalmol Vis Sci, 58, pp.2647~2651 (2017)
  14. Lee JH, "Prevalence of granular corneal dystrophy type 2(avellino corneal dystrophy)in the Korean population", Ophthalmic Epidemiol, 17, pp.160~165 (2010)
  15. Park JE, "Prevalence of granular corneal dystrophy type 2-related TGFBI p.R124H variant in a South Korean population", Mol Vis, 27, pp.283~287 (2021)
  16. Han KE, "Clinical findings and treatments of granular corneal dystrophy type 2(avellino corneal dystrophy) : a review of the literature", Eye Contact Lens, 36, pp.296~299 (2010)
  17. Jun I, "Long-term clinical outcomes of phototherapeutic keratectomy in corneas with granular corneal dystrophy type 2 exacerbated after LASIK", J Refract Surg, 34, pp.132~139 (2018)
  18. Kim SW, "Characteristic features of granular deposit formation in granular corneal dystrophy type 2", Cornea, 30, pp.848~854 (2011)
  19. Kim HS, "Association between visual acuity and the corneal area occupied by granular lesions, linear lesions, or diffuse haze in patients with granular corneal dystrophy type 2", Cornea, 37, pp.542~547 (2018)
  20. Hong JP, "Analysis of deposit depth and morphology in granular corneal dystrophy type 2 using fourier domain optical coherence tomography", Cornea, 30, pp.729~738 (2011)
  21. Nakamura T, "Refractive outcomes after phototherapeutic refractive keratectomy for granular corneal dystrophy", Cornea, 37, pp.548~553 (2018)
  22. Fagerholm P, "Phototherapeutic keratectomy : 12 years of experience", Acta Ophthalmol Scand, 81, pp.19~32 (2003)
  23. Jung SH, "Phototherapeutic keratectomy in diffuse stromal haze in granular corneal dystrophy type 2", Cornea, 32, pp.296~300 (2013)
  24. Wilson SE, "Phototherapeutic keratectomy : science and art", J Refract Surg, 33, pp.203~210 (2017)
  25. Han KE, "Pathogenesis and treatments of TGFBI corneal dystrophies", Prog Retin Eye Res, 50, pp.67~88 (2016)
  26. Das S, "Excimer laser phototherapeutic keratectomy for granular and lattice corneal dystrophy : a comparative study", J Refract Surg, 21, pp.727~731 (2005)
  27. Rapuano CJ, "Phototherapeutic keratectomy : who are the best candidates and how do you treat them?", Curr Opin Ophthalmol, 21, pp.280~282 (2010)
  28. Applegate RA, "Corneal aberrations and visual performance after radial keratotomy", J Refract Surg, 14, pp.397~407 (1998)
  29. Dinh R, "Recurrence of corneal dystrophy after excimer laser phototherapeutic keratectomy", Ophthalmology, 106, pp.1490~1497 (1999)
  30. Inoue T, "Recurrence of corneal dystrophy resulting from an R124H Big-h3 mutation after phototherapeutic keratectomy", Cornea, 21, pp.570~573 (2002)
  31. Hohberger B, "Measuring contrast sensitivity in normal subjects with OPTEC 6500 : influence of age and glare", Graefes Arch Clin Exp Ophthalmol, 245, pp.1805~1814 (2007)
  32. Aslam TM, "Principles of disability glare measurement : an ophthalmological perspective", Acta Ophthalmol Scand, 85, pp.354~360 (2007)
  33. Abrahamsson M, "Impairment of contrast sensitivity function(CSF)as a measure of disability glare", Invest Ophthalmol Vis Sci, 27, pp.1131~1136 (1986)
  34. Patterson EJ, "Understanding disability glare : light scatter and retinal illuminance as predictors of sensitivity to contrast", J Opt Soc Am A Opt Image Sci Vis, 32, pp.576~585 (2015)
  35. Mainster MA, "Glare's causes, consequences, and clinical challenges after a century of ophthalmic study", Am J Ophthalmol, 153, pp.587~593 (2012)
  36. Paulsson LE, "Contrast sensitivity in the presence of a glare light. theoretical concepts and preliminary clinical studies", Invest Ophthalmol Vis Sci, 19, pp.401~406 (1980)
  37. Cabrerizo J, "Changes in color vision and contrast sensitivity after descemet membrane endothelial keratoplasty for fuchs endothelial dystrophy", Cornea, 33, pp.1010~1015 (2014)
  38. Oie Y, "Evaluation of visual quality in patients with fuchs endothelial corneal dystrophy", Cornea, 35(Suppl 1), pp.S55~S58 (2016)
  39. Koh S, "Quantitative evaluation of visual function in patients with cornea verticillata associated with Fabry disease", Acta Ophthalmol, 97, pp.e1098~104 (2019)
  40. Lasa MS, "Contrast and glare sensitivity. association with the type and severity of the cataract", Ophthalmology, 99, pp.1045~1049 (1992)
  41. "Visual acuity" (2017)[URL]
  42. Iyer KK, "Conducting shorter VEP tests to estimate visual acuity via assessment of SNR", Doc Ophthalmol, 126, pp.21~28 (2013)
  43. Elliott DB, "Assessing the reliability, discriminative ability, and validity of disability glare tests", Invest Ophthalmol Vis Sci, 34, pp.108~119 (1993)
  44. Legge GE, "Psychophysics of reading--II. Low vision", Vision Res, 25, pp.253~265 (1985)
  45. Marron JA, "Visual factors and orientation-mobility performance", Am J Optom Physiol Opt, 59, pp.413~426 (1982)
  46. Regan D, "Low-contrast letter charts as a test of visual function", Ophthalmology, 90, pp.1192~1200 (1983)
  47. Moon JW, "Homozygous granular corneal dystrophy type II(avellino corneal dystrophy) : natural history and progression after treatment", Cornea, 26, pp.1095~1100 (2007)
  48. Jun I, "Compound heterozygous mutations in TGFBI cause a severe phenotype of granular corneal dystrophy type 2", Sci Rep, 11, pp.6986~ (2021)
  49. Watanabe S, "Relationship between corneal guttae and quality of vision in patients with mild Fuchs' endothelial corneal dystrophy", Ophthalmology, 122, pp.2103~2109 (2015)
  50. Strang NC, "Effects of defocus and pupil size on human contrast sensitivity", Ophthalmic Physiol Opt, 19, pp.415~426 (1999)

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