Methazolamide와 acetazolamide 복용후 유발된 천식 1례

Abstract

Acetazolamide and methazolamide are carbonic anhydrase inhibitors commonly used for lowering intraocular pressure in glaucoma and other ophthalmic diseases. They are unsubstituted sulfonamide derivatives that are known to cause many adverse side effects, including hyperchloremic metabolic acidosis, drowsiness, paresthesis, fever, rash and interstitial nephritis. A case of Steven-Johnson syndrome resulting from allergic reaction of anhydrase Inhibitor has recently been reported but cases of acetazolamide- and methazolamide- induced asthma in adults as respiratory response have not been reported in Korea. We report a case of methazolamide- and acetazolamide- induced asthma with a review of the literature. (Korean J Asthma, Allergy Clin Immunol 2004;24:261-264)