Diesel Exhaust Particles and Asthma
2
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
It has been demonstrated that particulate air pollutants, such as diesel exhaust particles (DEP), are related to allergic respiratory disorders including asthma and allergic rhinitis by extensive epidemiological studies. To perform environmental control with good cost-effective performance, it is crucial to elucidate the cellular and molecular mechanisms of effects of particulate pollutants. In vivo and in vitro studies so far strongly suggest that DEP may induce both anti- and pro-inflammatory compounds by activating their transcription. In conjunction with allergen, diesel exhaust particles can act as an adjuvant to enhance IgE antibody responses, and induce T-helper 2 (Th2) cytokine, chemokine and adhesion molecule expression. Studies have elucidated that DEP activate several signaling pathways such as mitogen-activated protein kinases and transcription factors especially NFkappaB, and these effects are thought to be via production of reactive oxygen species. Antioxidants reduce the allergic inflammatory effects of diesel exhaust particles in vitro and in mice. Therefore, host responses to DEP might be regulated by balance between antioxidants and proinflammatory responses. Recent human studies highlighted a possibility of chemoprevention against DEP-induced health effect in susceptible people.
참고문헌 (75)
- "Diesel fumes and the rising prevalence of atopy: an urban legend?", 3, pp.146~152 (2003)
- "Yu CP. Deposition of diesel exhaust particles in mammalian lungs a comparison between rodents and man. Aerosol Sci Technol 1987", pp.117~23
- "The national morbidity, mortality, and air pollution study. Part II: morbidity and mortality from air pollution in the United States", 94, pp.5~79 (2000)
- "Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution", 287, pp.1132~1141 (2002)
- "et al. An association between air pollution and mortality in six US cities. N Engl J Med 1993", pp.1753~9
- "Is daily mortality associated specifically with fine particles?", 46, pp.927~939 (1996)
- "Fine particle air pollution and mortality in 20 U.S. cities, 1987~1994", 343, pp.1742~1749 (2000)
- "Lung cancer, cardiopulmonary mortality, and long- term exposure to fine particulate air pollution", 287, pp.1132~1141 (2000)
- "Mittleman MA. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 201", pp.2810~5
- "Particles, and not gases, are associated with the risk of death in patients with chronic obstructive pulmonary disease", 30, pp.1138~1140 (2001)
- "Showdown over clean air science", 277, pp.466~469 (1997)
- "Particulate air pollution and mortality? Cleaning the air", 343, pp.1798~1799 (2000)
- "Proposed air pollutant standards", 277, pp.15~15 (1997)
- "Air pollution and bronchitic symptoms in Southern California children with asthma", 107, pp.757~760 (1999)
- "The National Morbidity, Mortality, and Air Pollution Study 2000. Part 2. Morbidity, mortality, and air pollution in the United States", (94) (2000), Mass The Health Effects Institute
- "Short-term effects of ambient sulphur dioxide and particulate matter on mortality in 12 European cities: results from the APHEA Project", 314, pp.1658~1663 (1997)
- "et al. An association between air pollution and mortality in six U.S. cities. N Engl J Med 1993", pp.1753~9
- "The role of particulate matter in exacerbation of atopic asthma", 124, pp.109~112 (2001)
- "Validation of a rhinitis symptom questionnaire (ISAAC core questions) in a population of Swiss school children visiting the school health services. SCARPOL- team. Swiss study on childhood allergy and respiratory symptom with respect to air pollution and climate. International Study of Asthma and Allergies in Childhood", 8, pp.75~82 (1997)
- "Acute effects of ambient inhalable particles in asthmatic and nonasthmatic children", 157(4), pp.1034~1043 (1998)
- "Air pollution and respiratory health among children with asthmatic or cough symptoms", 156, pp.546~552 (1997)
- "Acute effects of ambient inhalable particles in asthmatic and nonasthmatic children", 157, pp.1034~1043 (1998)
- "Environmental risk factors for respiratory and skin atopy: results from epidemiological studies in former East and West Germany", 118, pp.403~407 (1999)
- "Air quality in postunification Erfurt, East Germany: associating changes in pollutant concentrations with changes in emissions", 109, pp.325~333 (2001)
- "Urban traffic and pollutant exposure related to respiratory outcomes and atopy in a large sample of children", 21, pp.956~963 (2003)
- "Traffic-related air pollution and respiratory symptoms in children living along trunk roads in Chiba Prefecture, Japan", 13, pp.108~119 (2003)
- "Allergic susceptibility associated with diesel exhaust particle exposure: clear as mud", 57, pp.188~193 (2002)
- "Traffic volumes and respiratory health care utilization among residents in close proximity to the Peace Bridge before and after", 40, pp.855~864 (2003)
- "Saxon A. Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. J Clin Invest 1994", pp.1417~25
- "Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles", 98, pp.114~123 (1996)
- "In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines rantes, MIP-1α and MCP-3 in humans", 97, pp.140~145 (2000)
- "Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers", 159, pp.702~709 (1999)
- "Acute exposure to diesel exhaust increases IL-8 and GRO-α production in healthy human airways", 161, pp.550~557 (2000)
- "Comparison of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients and the effect of diesel exhaust particles in vitro", 102, pp.771~782 (1998)
- "Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel", 23, pp.82~86 (2004)
- "Health effects of acute exposure to air pollution. Part I: Healthy and asthmatic subjects exposed to diesel exhaust", 112, pp.1~30 (2003)
- "et al. Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice. J Allergy Clin Immunol 1986", pp.616~23
- "Biological effects of diesel exhaust particles (DEP) III. Pathogenesis of asthma like symptoms in mice", 21, pp.199~209 (1996)
- "Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice", 156, pp.36~42 (1997)
- "Diesel exhaust enhances allergic airway inflammation and hyperresponsiveness in mice", 157, pp.1138~1144 (1998)
- "Diesel exhaust particulate induces airway hyperresponsiveness in a murine model: essential role of GM-CSF", 104, pp.1024~1030 (1999)
- "Platelet-derived growth factor is involved in the augmentation of airway responsiveness through remodeling of airways in diesel exhaust particulate-treated mice", 107, pp.135~142 (2001)
- "Long-term inhalation of diesel exhaust affects cytokine expression in murine lung tissues: comparison between low- and high-dose diesel exhaust exposure", 28, pp.493~506 (2002)
- "Inhalation of diesel exhaust for three months affects major cytokine expression and induces bronchus-associated lymphoid tissue formation in murine lungs", 29, pp.607~622 (2003)
- "Diesel exhaust particles suppress in vivo IFN-gamma production by inhibiting cytokine effects on NK and NKT cells", 172, pp.3808~3813 (2004)
- "Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models", 112, pp.905~914 (2003)
- "Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro", 101, pp.778~785 (1998)
- "Diesel exhaust particles induce NF-κB activation in human bronchial epithelial cells in vitro: importance in cytokine transcription", 162, pp.4705~4701 (1999)
- "Diesel exhaust particles up-regulate expression of intracellular adhesion molecule-1 (ICAM-1) in human bronchial epithelial cells", 120, pp.356~362 (2001)
- "Mechanisms of GM-CSF increase by diesel exhaust particles in human airway epithelial cells", 278, pp.L25~L32 (2000)
- "Benzene-extracted components are important for the major activity of diesel exhaust particles", 24, pp.419~426 (2001)
- "Diesel exposure favors Th2 cell recruitment by mononuclear cells and alveolar macrophages from allergic patients by differentially regulating macrophage-derived chemokine and IFN-γ-induced protein-10 production", 168, pp.5912~5219 (2002)
- "Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages", 169, pp.4531~4541 (2002)
- "Effects of diesel exhaust on murine alveolar macrophages and a macrophage cell line", 28, pp.201~217 (2002)
- "Enhanced human IgE production results from exposure to the aromatic hydrocarbons from diesel exhaust: direct effects on B-cell IgE production", 95, pp.103~115 (1995)
- "The environmental pollutant pyrene induces the production of IL-4", 105, pp.796~802 (2000)
- "Effect of diesel on chemokines and chemokine receptors involved in helper T cell type 1", type 2 recruitment in patients with asthma, 2003, pp.168, 215~221
- "Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils", 109, pp.847~853 (2002)
- "Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by Human bronchial epithelial cells and N-acetylcysteine attenuates p38 MAP kinase activation", 161, pp.280~285 (2000)
- "Macrophage activation by polycyclic aromatic hydrocarbons: evidence for the involvement of stress-activated protein kinases, activator protein-1, and antioxidant response elements", 161, pp.942~951 (1998)
- "Regulation of gene expression by oxygen: NF-κB and HIF-1, two extremes", 33, pp.1231~1242 (2002)
- "H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activation", 27, pp.1197~1202 (1999)
- "UV activates growth factor receptors via reactive oxygen intermediates", 133, pp.211~220 (1996)
- "Nuclear factor-κB- a pivotal transcription factor in chronic inflammatory diseases", 336, pp.1066~1071 (1997)
- "The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin", 33, pp.1371~1379 (2003)
- "Organic compounds from diesel exhaust particles elicit a proinflammatory response in human airway epithelial cells and induce cytochrome p450 1a1 expression", 25, pp.515~521 (2001)
- "Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element", 165, pp.3393~3401 (2000)
- "cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles", 67, pp.241~246 (2002)
- "Oxidative-stress potency of organic extracts of diesel exhaust and urban fine particles in rat heart microvessel endothelial cells", 187, pp.161~170 (2003)
- "Peroxynitrite formation by diesel exhaust particles in alveolar cells: Links to pulmonary inflammation", 9, pp.1~8 (2000)
- "Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal admini-", 20, pp.1573~1576 (1999)
- "Involvement of superoxide and nitric oxide on airway inflammation and hyperresponsiveness induced by diesel exhaust particles in mice", 25, pp.635~644 (1998)
- "Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization", 168, pp.2560~2567 (2002)
- "Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study", 363, pp.119~125 (2004)
- "Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City", 59, pp.8~10 (2004)
