트리클로로에틸렌의 직업적 노출에 의한 과민성 박탈 피부염 및 간염 1예
A Case of Hypersensitive Exfoliative Dermatitis with Hepatitis after a Occupational Exposure to Trichloroethylene
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A 20-year-old man was admitted to the hospital because of pruritus, pyrexia and maculopapular skin rash. Three weeks before admission, he engaged in silicon waterproofing work with trichloroethylene (TCE). The levels of liver enzymes increased and exfoliative dermatitis was developed on the trunk and face. After treatment with systemic corticosteroids, antihistamine and liver supplements, liver function and skin lesions were improved remarkably. The levels of serum IgE increased and the pathological examination of skin specimen revealed T lymphocyte-mediated inflammatory reaction. Since other causes could not be found through the multiple allergen simultaneous test (MAST) and other allergy tests, we assumed that exfoliative dermatitis and hepatitis were caused by T lymphocyte hypersensitivity to TCE, which was confirmed by the patch test after his symptoms were improved.
Abstract
A 20-year-old man was admitted to the hospital because of pruritus, pyrexia and maculopapular skin rash. Three weeks before admission, he engaged in silicon waterproofing work with trichloroethylene (TCE). The levels of liver enzymes increased and exfoliative dermatitis was developed on the trunk and face. After treatment with systemic corticosteroids, antihistamine and liver supplements, liver function and skin lesions were improved remarkably. The levels of serum IgE increased and the pathological examination of skin specimen revealed T lymphocyte-mediated inflammatory reaction. Since other causes could not be found through the multiple allergen simultaneous test (MAST) and other allergy tests, we assumed that exfoliative dermatitis and hepatitis were caused by T lymphocyte hypersensitivity to TCE, which was confirmed by the patch test after his symptoms were improved.
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