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약물 과민반응 증후군: 바이러스 재활성화 연관성에 대한 문헌 고찰

Drug Hypersensitivity Syndrome: A Literature Review of Associated Viral Reactivation

장윤석|송우정
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)|2011.06|천식 및 알레르기|제31권 제2호|pp. 77-83

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키워드

humanDrug hypersensitivityDrug eruptionsHerpesvirus 6Virus activation
주제분류임상병리학

초록

Drug hypersensitivity syndrome is a severe adverse drug reaction characterized by skin eruption and systemic manifestations, such as fever, eosinophilia, lymph node enlargement, hepatitis and renal dysfunction. The pathogenic mechanism of this syndrome is considered multifactorial but still remains to be elucidated. An interesting point is a possible association between drug reaction and herpesvirus reactivation. Since the first case reported by Descamps et al in 1997, there have been scores of reported cases suggesting this association, also being supported by clinical observation of flare-up of disease during the recovery phase. The purpose of this review is to describe its clinical characteristics and to evaluate the possibility of drug and viral interactions in the development of this syndrome through a literature review.

Abstract

Drug hypersensitivity syndrome is a severe adverse drug reaction characterized by skin eruption and systemic manifestations, such as fever, eosinophilia, lymph node enlargement, hepatitis and renal dysfunction. The pathogenic mechanism of this syndrome is considered multifactorial but still remains to be elucidated. An interesting point is a possible association between drug reaction and herpesvirus reactivation. Since the first case reported by Descamps et al in 1997, there have been scores of reported cases suggesting this association, also being supported by clinical observation of flare-up of disease during the recovery phase. The purpose of this review is to describe its clinical characteristics and to evaluate the possibility of drug and viral interactions in the development of this syndrome through a literature review.

참고문헌 (53)

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관련 논문AI추천

Drug Reaction with Eosinophilia and Systemic Symptoms Associated with Reactivation of Epstein-Barr Virus and/or Cytomegalovirus Leading to Hemophagocytic Syndrome in One of Two PatientsAiping Wang, Hui Qu, Jianhua Liang, Lingling Liu, Mingyue Wang, Ping Tu, Ruoyu Li, Xiaowen Wang대한피부과학회 · Annals of Dermatology2018 · 제30권 제1호DRESS (drug reaction with eosinophilia and systemic symptoms) 증후군에 속발된 거대세포바이러스 재활성화 관련 독성표피괴사융해 1예고영일, 손세영, 심다운, 유지은대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2020 · 제8권 제1호1차 및 2차 항결핵제에 의한 DRESS (drug reaction with eosinophilia and systemic symptom) 증후군 1예와 문헌고찰강동윤, 강성윤, 강혜련, 손경희, 이창훈, 장동연, 황영훈대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2017 · 제5권 제2호혈관염을 동반한 DRESS 증후군 1예고영일, 박상훈, 위정욱, 윤병조, 진남철, 한의령대한천식알레르기학회 · 천식 및 알레르기2010 · 제30권 제4호Drug rash with eosinophilia and systemic symptoms syndrome following cholestatic hepatitis A: a case report박소은, 심주현, 안지현, 유은실, 윤선영, 이단비, 이유미, 이주호, 이한주, 이효정대한간학회 · Clinical and Molecular Hepatology2012 · 제18권 제1호9세 소아에서 아세트아미노펜에 의한 드레스증후군 1예양승, 백혜성, 송한솔, 최우혁, 최원복, 황일태대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2016 · 제4권 제4호

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