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논문KCI 등재

Fibroblast Growth Factor2 유전자의 단일염기유전자다형과 천식의 중증도와의 연관성분석

Association study between asthma severity and single nucleotide polymorphisms of fibroblast growth factor 2

임은영|오선영|권혁수|장윤석|김상헌|김태범|김윤근|김경묵|김유영|정이영|조상헌|민경업|권용은|박홍우|박혜경|신은순
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)|2004.12|천식 및 알레르기|제24권 제4호|pp. 421-427

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참고문헌

주제분류임상병리학

초록

Abstract

Background: Thickening of subepithelial reticular layer is one of the main features of airway remodeling in asthma and is known to be enhanced in severe asthmatics. Fibroblast growth factor 2 (FGF2) is a main growth factor in wound healing process after immunologic and nonimmunologic injury. Objective: This study was aimed to evaluate the association between asthma severity and genetic polymorphisms of FGF2 gene. Method: One hundred six asthmatics and twenty healthy controls were enrolled. Severe asthma was defined by a condition that require treatment with high-dose inhaled corticosteroids and other controller medications to achieve good asthma control. Single nucleotide polymorphisms (SNPs) of FGF2 gene were discovered by direct DNA sequencing in the 30 asthmatic and 20 healthy subjects. The discovered SNPs were scored by single base extension method in the asthmatics. Result: Three synonymous SNPs (662T＞C, 65471A＞G, and 754C＞G) of FGF2 gene were discovered and scored. The genotype frequencies of those SNPs were not different between asthmatics and controls. The frequencies of individual SNPs and haplotypes of 662T＞C and 754C＞G were not different between severe and mild to moderate asthmatics. Conclusion: The SNPs of FGF2 gene were not associated with asthma severity.

참고문헌 (25)

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