EXO1 is a Potential Prognostic Biomarker in Lung Cancer
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Lung cancer is one of the most common malignancies worldwide and remains the leading cause of cancerrelated deaths. Exonuclease 1 (EXO1) is involved in several critical biological processes, including mismatch repair, double-strand break repair, and nucleotide excision repair. However, its precise role and association with lung cancer (LC) have not been fully elucidated. In this study, we investigated the clinicopathological and prognostic significance of EXO1 mRNA expression in 102 patients with LC. No statistically significant associations were observed between EXO1 expression and clinicopathological variables. However, survival analysis revealed that low EXO1 expression was significantly associated with poorer overall survival. Notably, among patients with squamous cell carcinoma (SCC), those with low EXO1 expression had significantly shorter overall survival compared to those with high expression levels. Our findings suggest that EXO1 may serve as a potential prognostic biomarker, particularly in SCC.
Abstract
Lung cancer is one of the most common malignancies worldwide and remains the leading cause of cancerrelated deaths. Exonuclease 1 (EXO1) is involved in several critical biological processes, including mismatch repair, double-strand break repair, and nucleotide excision repair. However, its precise role and association with lung cancer (LC) have not been fully elucidated. In this study, we investigated the clinicopathological and prognostic significance of EXO1 mRNA expression in 102 patients with LC. No statistically significant associations were observed between EXO1 expression and clinicopathological variables. However, survival analysis revealed that low EXO1 expression was significantly associated with poorer overall survival. Notably, among patients with squamous cell carcinoma (SCC), those with low EXO1 expression had significantly shorter overall survival compared to those with high expression levels. Our findings suggest that EXO1 may serve as a potential prognostic biomarker, particularly in SCC.