살리실산제제에 의한 급성 전신성 발진성 농포증 1예
A Case of Acute Generalized Exanthematous Pustulosis Induced by Sodium Salicylate
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Background: Acute generalized exanthematous pustulosis (AGEP) is a rare disease mostly related to drug eruption. The skin lesions present as widespread sterile pustules on erythematous bases, usually accompanied by fever and leukocytosis. Case History: A 62 year old woman presented with generalized multiple tiny pustules and erythematous confluent patches on the trunk and proximal extremities. Two weeks ago, a sodium salicylate agent was injected at a local clinic to subside chilling sensation. The skin lesion appeared 10days after the injection and was accompanied by a high fever. Results: Laboratory tests revealed leukocytosis and elevated erythrocyte sedimentation rate. The histopathological examination of the skin biopsy specimen showed subcorneal spongiform pustules with perivascular inflammatory cell infiltration. The patient was diagnosed with AGEP and treated with systemic steroids and antihistamines. The lesion resolved after 3 weeks. Conclusion: Herein, we report a rare case of AGEP induced by sodium salicylate injection.
Abstract
Background: Acute generalized exanthematous pustulosis (AGEP) is a rare disease mostly related to drug eruption. The skin lesions present as widespread sterile pustules on erythematous bases, usually accompanied by fever and leukocytosis. Case History: A 62 year old woman presented with generalized multiple tiny pustules and erythematous confluent patches on the trunk and proximal extremities. Two weeks ago, a sodium salicylate agent was injected at a local clinic to subside chilling sensation. The skin lesion appeared 10days after the injection and was accompanied by a high fever. Results: Laboratory tests revealed leukocytosis and elevated erythrocyte sedimentation rate. The histopathological examination of the skin biopsy specimen showed subcorneal spongiform pustules with perivascular inflammatory cell infiltration. The patient was diagnosed with AGEP and treated with systemic steroids and antihistamines. The lesion resolved after 3 weeks. Conclusion: Herein, we report a rare case of AGEP induced by sodium salicylate injection.
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