Vitamin K1 근육주사 후 발생한 피부염 1예
A Case of Vitamin K1 Induced Allergic Dermititis
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Background: Vitamin K1 (phytonadione), a fat-soluble vitamin,has widely been used to correct bleeding tendency. Although delayed hypersensitivity to vitamin K in new borns is relatively well known, it has rarely been reported in adults. Case History: A 39-year-old woman with thyroid cancer presented with eczematous erythema and severe itching sense with local heat on her right buttock that occurred after intramuscular injection of vitamin K1 7 days ago. She had received intramuscular injections of vitamin K1 to correct bleeding tendency before total thyroidectomy. Results: The pathologic findings of a skin biopsy specimen revealed vacuolar dermatitis with perivascular inflammatory cell infiltration. The skin lesion rapidly improved after administration of oral prednisolone (30 mg/day), a topical steroid,and an oral antihistamine for 5 days. After resolution of the primary lesion, a patch test with vitamin K1 was performed. The patient showed a positive reaction to vitamin K1 with an erythematous plaque with blistering at vitamin K1 injection site. Conclusion: We report here in a case of vitamin K1-induced delayed hypersensitivity reaction confirmed by a patch test.
Abstract
Background: Vitamin K1 (phytonadione), a fat-soluble vitamin,has widely been used to correct bleeding tendency. Although delayed hypersensitivity to vitamin K in new borns is relatively well known, it has rarely been reported in adults. Case History: A 39-year-old woman with thyroid cancer presented with eczematous erythema and severe itching sense with local heat on her right buttock that occurred after intramuscular injection of vitamin K1 7 days ago. She had received intramuscular injections of vitamin K1 to correct bleeding tendency before total thyroidectomy. Results: The pathologic findings of a skin biopsy specimen revealed vacuolar dermatitis with perivascular inflammatory cell infiltration. The skin lesion rapidly improved after administration of oral prednisolone (30 mg/day), a topical steroid,and an oral antihistamine for 5 days. After resolution of the primary lesion, a patch test with vitamin K1 was performed. The patient showed a positive reaction to vitamin K1 with an erythematous plaque with blistering at vitamin K1 injection site. Conclusion: We report here in a case of vitamin K1-induced delayed hypersensitivity reaction confirmed by a patch test.
참고문헌 (19)
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