전기방사에 의해 제조된 수수 추출물 함유 폴리비닐알코올 복합 나노 섬유의 생리활성 특성
Bioactive Characteristics of Sorghum Extract/Poly(vinyl alcohol) Composite Nanoweb Produced by Electrospinning
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Sorghum is a rich source in phytochemicals, such as tannins, phenolic acids, anthocyanins, phytosterols and policosanols. Sorghum has been known to have antimicrobial, antiinflammatory, antioxidant properties. In this study, poly(vinyl alcohol)(PVA)- sorghum extract(SE) composite nanoweb was produced by electrospinning and its characteristics including bioactivities were investigated. The SE had antimicrobial and antiinflammatory activities as well as a reduced cytotoxicity. The PVA-SE nanoweb had a highly enhanced antimicrobial activity compared to PVA nanoweb. The amount of proinflammatory cytokine released from macrophages treated with the PVA-SE nanoweb was reduced. The PVA-SE nanoweb can be a potential candidate for medical and cosmeceutical materials providing antimicrobial and antiinflammatory activities with a low degree of cytotoxicity.
Abstract
Sorghum is a rich source in phytochemicals, such as tannins, phenolic acids, anthocyanins, phytosterols and policosanols. Sorghum has been known to have antimicrobial, antiinflammatory, antioxidant properties. In this study, poly(vinyl alcohol)(PVA)- sorghum extract(SE) composite nanoweb was produced by electrospinning and its characteristics including bioactivities were investigated. The SE had antimicrobial and antiinflammatory activities as well as a reduced cytotoxicity. The PVA-SE nanoweb had a highly enhanced antimicrobial activity compared to PVA nanoweb. The amount of proinflammatory cytokine released from macrophages treated with the PVA-SE nanoweb was reduced. The PVA-SE nanoweb can be a potential candidate for medical and cosmeceutical materials providing antimicrobial and antiinflammatory activities with a low degree of cytotoxicity.
참고문헌 (32)
- S. Arai, "Recent Trends in Functional Food Science and the Industry in Japan", Biosci. Biotechnol. Biochem, 66(10), pp.2017~ (2002)
- H. R. Grimmer, "Antimutagenicity of Polyphenol-rich Fraction from Sorghum Bicolor Grain", J. Sci. Food Agric, 59(2), pp.251~ (1992)
- H. Y. Kil, "Antioxidant and Antimicrobial Activities of Crude SorghumExtract", Food Chem, 115(4), pp.1234~ (2009)
- J. M. Awika, "Anthocyanins from Black Sorghum and Their Antioxidant Properties", Food Chem, 90(1-2), pp.293~ (2004)
- L. Dykes, "Sorghum andMillet Phenols and Antioxidants", J. Cereal Sci, 44(3), pp.236~ (2006)
- J. M. Awika, "Sorghum Phytochemicals and Their Potential Impact on Human Health", Phytochemistry, 65(9), pp.1199~ (2004)
- J. M. Awika, "Processing of Sorghum(Sorghum Bicolor) and Content", J. Agric. Food Chem, 51(18), pp.5516~ (2003)
- H. Wang, "Oxygen Radical Absorbing Capacity of Anthocyanins", J. Agric. Food Chem, 45(2), pp.304~ (1997)
- S. N. Ryu, "High Performance LiquidChromatographicDetermination ofAnthocyanin Pigments in SomeVarieties ofBlackRice", J. FoodDrug Anal, 6(4), pp.729~ (1998)
- D. H. Hahn, "Sorghum Phenolic Acids, Their HPLC Separation and Their Relation to Fungal Resistance", Cereal Chem, 60(4), pp.255~ (1983)
- R. D. Waniska, "Effects of Growth Conditions on Grain Molding and Phenals in Sorghum Caryopsis", J. Cereal Sci, 10(3), pp.217~ (1989)
- R. Gujer, "Glucosylated Flavonoids and Other Phenolic Compounds from Sorghum", Phytochemistry, 25(6), pp.1431~ (1986)
- "J. Agric. Food Chem", 2003, 538~
- 곽충실, "한국산 메밀, 수수, 기장, 율무의 항산화효과 및 돌연변이억제효과", 한국식품영양과학회지, 33(6), pp.921~929 (2004), 한국식품영양과학회
- Y. H. Choi, "Inhibition Effect of Various Cereal and Bean Extracts on Carcinogenicity In Vitro", Korean J. Food Sci. Technol, 30(4), pp.964~ (1998)
- 류혜숙, "수수 물 추출물이 마우스 면역세포와 항체 생성능에 미치는 영향", 대한영양사협회 학술지, 12(1), pp.82~88 (2006), 대한영양사협회
- M. H. Dicko, "Evaluation of the Effect of Germination on Phenolic Compounds and Antioxidant Activities in Sorghum Varieties", J. Agric. Food Chem, 53(7), pp.2581~ (2005)
- 이하규, "한국산 잡곡류의 이화학적 특성과 항산화활성", 한국식품영양과학회지, 39(9), pp.1399~1404 (2010), 한국식품영양과학회
- I. K. Kim, "Fabrication and Characterization of Electrospun Zein Nanofibers Containing Sorghum Extract", M.S, pp.2012
- S. B. Yang, "Incorporation of Sorghum Extract into Electrospun Zein Nanofibers and Their Characterization", J. Nanosci. Nanotechnol, 17(12), pp.9002~ (2017)
- E. Chiellini, "Biodegradation of Poly(vinyl alcohol) BasedMaterials", Prog. Polym. Sci, 28(6), pp.963~ (2003)
- Q. Dong, "Poly(vinyl alcohol)-Based PolymericMembrane: Preparation and Tensile Properties", J. Appl. Polym. Sci, 122(2), pp.1350~ (2011)
- P. Alexy, "Poly(vinyl alcohol) Stabilisation in Thermoplastic Processing", Polym. Degrad. Stabil, 78(3), pp.413~ (2002)
- P. Y. Zhuang, "Modification ofChitosanMembranewith Poly(vinyl alcohol)and Biocompatibility Evaluation", Int. J. Biol. Macromol, 50(3), pp.658~ (2012)
- M. H. Huang, "Evaluation of Glucan", Poly(vinyl alcohol) BlendWound Dressing Using Rat Models, 2008, pp.346(1-2), 38~
- G. Paradossi, "Poly(vinyl alcohol) asVersatileBiomaterial for Potential Biomedical Applications", J. Mater. Sci. Mater. Med, 14(8), pp.687~ (2003)
- S. Y. Seo, "Alginate-BasedComposite SpongeContaining SilverNanoparticles Synthesized In Situ", Carbohydr. Polym, 90(1), pp.109~ (2012)
- S. Estevez-Arecoa, "Release Kinetics of Rosemary(Rosmarinus officinalis)Polyphenols from Polyvinyl Alcohol(PVA)ElectrospunNanofibers in Several Food Simulants", Food Packaging and Shelf Life, 18, pp.42~ (2018)
- H. J. Lee, "Antimicrobial Polyethyleneimine-SilverNanoparticles in a Stable Colloidal Dispersion", Colloid Surf. BBiointerfaces, 88(1), pp.505~ (2011)
- "ISO10993-5, Biological Evaluation ofMedicalDevices-Part 5: Tests for in vitro Cytotoxicity", ~ (2007)
- 강현, "Anti-Oxidative and Anti-Neuroinflammatory Effect of Ethanol Extracts from Walnuts's (Juglans regia L.) Shell", 대한의생명과학회지, 24(4), pp.365~371 (2018), 대한의생명과학회[DOI]
- G. H. Lee, "Antioxidative andAntiinflammatory Activities of Quercetin-Loaded Silica Nanoparticles", Colloid Surf. B-Biointerfaces, 143, pp.511~ (2016)