Iron Deficiency Anemia: The Possible Risk Factor of Complex Febrile Seizure and Recurrence of Febrile Seizure
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Purpose: A relationship between Febrile seizure (FS) and iron deficiency anemia (IDA) has been found in several studies. However, few studies have focused on the role of IDA in complex febrile seizures (CFS) and simple febrile seizures (SFS) and there is no report on whether IDA is a risk factor for recurrence. The aim of this study was to investigate the role of IDA in SFS and CFS and to examine the effect of IDA on recurrence. Methods: Patients (n=166) who had been diagnosed with FS were enrolled in our study. Subjects were divided into the following groups for analysis: the SFS and CFS groups, recurrence and non-recurrence groups. The onset age was compared in each group of patients and laboratory test results based on IDA were compared. Results: Between the SFS and the CFS groups, there was no significant difference in laboratory test results based on IDA. There was a significant difference in onset age between the two groups and the onset age tended to be lower in the CFS group (24.00 vs. 16.49 months) (P=0.004). Comparing recurrence and non-recurrence groups, the mean corpuscular volume was significantly different (P=0.043) with the recurrence group having a lower mean corpuscular volume level (78.92 vs. 77.48). The onset age in the recurrence group was lower (26.02 vs. 19.68 months). Conclusion: This study suggests that onset age could be a risk factor for CFS, and IDA may not contribute to elevating the risk of CFS. However, IDA may play an important role in the recurrence of FS.
Abstract
Purpose: A relationship between Febrile seizure (FS) and iron deficiency anemia (IDA) has been found in several studies. However, few studies have focused on the role of IDA in complex febrile seizures (CFS) and simple febrile seizures (SFS) and there is no report on whether IDA is a risk factor for recurrence. The aim of this study was to investigate the role of IDA in SFS and CFS and to examine the effect of IDA on recurrence. Methods: Patients (n=166) who had been diagnosed with FS were enrolled in our study. Subjects were divided into the following groups for analysis: the SFS and CFS groups, recurrence and non-recurrence groups. The onset age was compared in each group of patients and laboratory test results based on IDA were compared. Results: Between the SFS and the CFS groups, there was no significant difference in laboratory test results based on IDA. There was a significant difference in onset age between the two groups and the onset age tended to be lower in the CFS group (24.00 vs. 16.49 months) (P=0.004). Comparing recurrence and non-recurrence groups, the mean corpuscular volume was significantly different (P=0.043) with the recurrence group having a lower mean corpuscular volume level (78.92 vs. 77.48). The onset age in the recurrence group was lower (26.02 vs. 19.68 months). Conclusion: This study suggests that onset age could be a risk factor for CFS, and IDA may not contribute to elevating the risk of CFS. However, IDA may play an important role in the recurrence of FS.
참고문헌 (23)
- Syndi Seinfeld D, "Recent research on febrile seizures:a review", J Neurol Neurophysiol, 4 (2013)
- Shinnar S, "Febrile seizures", J Child Neurol, 17(17Suppl 1), pp.S44~S52 (2002)
- Ghasemi F, "Iron-deficiency anemia in children with febrile seizure: a case-control study", Iran J Child Neurol, 8, pp.38~44 (2014)
- Graves RC, "Febrile seizures: risks, evaluation, and prognosis", Am Fam Physician, 85, pp.149~153 (2012)
- van Stuijvenberg M, "Temperature, age, and recurrence of febrile seizure", Arch Pediatr Adolesc Med, 152, pp.1170~1175 (1998)
- Kobrinsky NL, "Does iron deficiency raise the seizure threshold?", J Child Neurol, 10, pp.105~109 (1995)
- Bidabadi E, "Association between iron deficiency anemia and first febrile convulsion: A case-control study", Seizure, 18, pp.347~351 (2009)
- Sharif MR, "The relationship between iron deficiency and febrile convulsion: a casecontrol study", Glob J Health Sci, 8, pp.185~189 (2015)
- Hartfield DS, "The association between iron deficiency and febrile seizures in childhood", Clin Pediatr (Phila), 48, pp.420~426 (2009)
- Naveed ur R, "Association between iron deficiency anemia and febrile seizures", J Coll Physicians Surg Pak, 15, pp.338~340 (2005)
- Pisacane A, "Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years", Bmj, 313, pp.343~ (1996)
- Kwak BO, "Relationship between iron deficiency anemia and febrile seizures in children: a systematic review and meta- analysis", Seizure, 52, pp.27~34 (2017)
- Ozaydin E, "Differences in iron deficiency anemia and mean platelet volume between children with simple and complex febrile seizures", Seizure, 21, pp.211~214 (2012)
- Berg AT, "Predictors of recurrent febrile seizures. A prospective cohort study", Arch Pediatr Adolesc Med, 151, pp.371~378 (1997)
- Berg AT, "A prospective study of recurrent febrile seizures", N Engl J Med, 327, pp.1122~1127 (1992)
- Kliegman R, "Nelson textbook of pediatrics", pp.2310~ (2016)
- 전윤수, "영아에서 철결핍 빈혈과 열성경련과의 상관관계", Clinical and Experimental Pediatrics, 53(3), pp.392~396 (2010), 대한소아청소년과학회
- Lozoff B, "Long-lasting neural and behavioral effects of iron deficiency in infancy", Nutr Rev, 64, pp.S34~S43 (2006)
- Rouault TA, "Brain iron metabolism", Semin Pediatr Neurol, 13, pp.142~148 (2006)
- Beard JL, "Neurobehavioral analysis of developmental iron deficiency in rats", Behav Brain Res, 134, pp.517~524 (2002)
- Angulo-Kinzler RM, "Twenty-four-hour motor activity in human infants with and without iron deficiency anemia", Early Hum Dev, 70, pp.85~101 (2002)
- Idjradinata P, "Reversal of developmental delays in irondeficient anaemic infants treated with iron", Lancet, 341, pp.1~4 (1993)
- Aziz KT, "Iron deficiency anaemia as risk factor for simple febrile seizures: a case control study", J Ayub Med Coll Abbottabad, 29, pp.316~319 (2017)