젖소에서 epinephrine 및 insulin에 의한 대사 조절
Roles of Epinephrine and Insulin in the Regulation of Metabolism in Dairy Cow
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초록
젖소의 분만 전․후기는 일반적으로 전환기라고 칭하며 분만후 유생산을 준비하기 위해 동물체내 대사 및 생리적 상태가 급격히 변화하는 시기라 할 수 있다. 젖소는 이 시기에 간조직에서 당신합성을 통해 유당합성을 위한 glucose의 생산을 촉진하고, 지방조직에서는 분만 전부터 지질을 축적하고 비유개시에 맞추어 혈중 NEFA (nonesterified fatty acid)의 농도를 증가시켜 유지방 합성을 준비한다. 이러한 대사조절에 epinephrine 및 insulin이 조절 호르몬으로 작용하여 유생산을 위한 탄수화물 및 지질대사를 변화시키고 사료 섭취량의 부족에 기인한 전체 에너지의 감소를 체내 영양소의 재분배로 충족시킨다.
Abstract
The transition from pregnancy to lactation, commonly referred to as the "transition period" is characterized by dramatic changes in metabolic processes and their regulation in order to prepare the dairy cow for parturition and lactogenesis. An important adaptation to lactation is the increase in gluconeogenesis by the liver to meet the tremendous increase in demand of glucose for lactose synthesis, and the accumulation of lipid in adipose tissue during pregnancy, its mobilization that begins prior to lactation and the dramatic increase in plasma NEFA concentration early lactation. Epinephrine and insulin, the homeostatic regulators of metabolism are responsible for the adaptations of lipid and carbohydrate metabolism in support of milk production along with mobilization of body fat to meet overall energy demands because dry matter intake is insufficient to meet these demands during early lactation.
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