본문 바로가기
KERD
논문KCI 등재

An evolving integrative physiology: skeleton and energy metabolism

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류화학

초록

The adipocyte-derived hormone leptin regulates appetite and bone mass. Recent research demonstrates that reciprocally, osteoblasts have a role in controlling energy metabolism. Several genes expressed in osteoblasts are involved in this process,and one of them is the Esp gene. The remaining genes regulate Esp gene expression. OST-PTP, the protein name of Esp, regulates the carboxylation of osteocalcin secreted from osteoblasts,thus affecting insulin sensitivity and insulin secretion. This review provides evidence for a novel interpretation of the connection between bone and energy metabolism and expands our understanding of the novel physiology of bone beyond its classical functions.

Abstract

The adipocyte-derived hormone leptin regulates appetite and bone mass. Recent research demonstrates that reciprocally, osteoblasts have a role in controlling energy metabolism. Several genes expressed in osteoblasts are involved in this process,and one of them is the Esp gene. The remaining genes regulate Esp gene expression. OST-PTP, the protein name of Esp, regulates the carboxylation of osteocalcin secreted from osteoblasts,thus affecting insulin sensitivity and insulin secretion. This review provides evidence for a novel interpretation of the connection between bone and energy metabolism and expands our understanding of the novel physiology of bone beyond its classical functions.

참고문헌 (44)

  1. Teitelbaum, S. L., "Genetic regulation of osteoclast development and function", Nat. Rev. Genet., 4, pp.638~649 (2003)
  2. Harada, S., "Control of osteoblast function and regulation of bone mass", Nature, 423, pp.349~355 (2003)
  3. Raisz, L. G., "Clinical practice. Screening for osteoporosis", N. Engl. J. Med., 353, pp.164~171 (2005)
  4. Riggs, B. L., "A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men", J. Bone Miner. Res., 13, pp.763~773 (1998)
  5. Ricci, T. A., "Moderate energy restriction increases bone resorption in obese postmenopausal women", Am. J. Clin. Nutr., 73, pp.347~352 (2001)
  6. Grinspoon, S., "Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa", Ann. Intern. Med., 133, pp.790~794 (2000)
  7. Karsenty, G., "Convergence between bone and energy homeostases: leptin regulation of bone mass", Cell Metab., 4, pp.341~348 (2006)
  8. Felson, D. T., "Effects of weight and body mass index on bone mineral density in men and women: the Framingham study", J. Bone Miner. Res., 8, pp.567~573 (1993)
  9. Tremollieres, F. A., "Vertebral postmenopausal bone loss is reduced in overweight women: a longitudinal study in 155 earlypostmenopausal women", J. Clin. Endocrinol. Metab., 77, pp.683~686 (1993)
  10. Ahima, R. S., "Body fat, leptin, and hypothalamic amenorrhea", N. Engl. J. Med., 351, pp.959~962 (2004)
  11. Spiegelman, B. M., "Obesity and the regulation of energy balance", Cell, 104, pp.531~543 (2001)
  12. Auwerx, J., "Leptin", Lancet, 351, pp.737~742 (1998)
  13. Ducy, P., "Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass", Cell, 100, pp.197~207 (2000)
  14. Ahima, R. S., "Leptin regulation of neuroendocrine systems", Front. Neuroendocrinol., 21, pp.263~307 (2000)
  15. Elefteriou, F., "Leptin regulation of bone resorption by the sympathetic nervous system and CART", Nature, 434, pp.514~520 (2005)
  16. Martin, A., "Leptin modulates both resorption and formation while preventing disuse-induced bone loss in tail-suspended female rats", Endocrinology, 146, pp.3652~3659 (2005)
  17. Cornish, J., "Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo", J. Endocrinol., 175, pp.405~415 (2002)
  18. Elefteriou, F., "Serum leptin level is a regulator of bone mass", Proc. Natl. Acad. Sci. U.S.A., 통권 : 101, pp.3258~3263 (2004)
  19. Lian, J., "Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression", Proc. Natl. Acad. Sci. U.S.A., 통권 : 86, pp.1143~1147 (1989)
  20. Hauschka, P. V., "Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone", Physiol. Rev., 69, pp.990~1047 (1989)
  21. Price, P. A., "Gla-containing proteins of bone", Connect. Tissue. Res., 21, pp.51~57 (1989)
  22. Hetzel, P. G., "Coumarin embryopathy in an extremely low birth weight infant associated with neonatal hepatitis and ocular malformations", Eur. J. Pediatr., 165, pp.358~360 (2006)
  23. Obrant, K. J., "The proportion of carboxylated to total or intact osteocalcin in serum discriminates warfarin-treated patients from control subjects", J. Bone. Miner. Res., 14, pp.555~560 (1999)
  24. Sayinalp, S., "Increasing serum osteocalcin after glycemic control in diabetic men", Calcif. Tissue Int., 57, pp.422~425 (1995)
  25. Lee, N. K., "Endocrine regulation of energy metabolism by the skeleton", Cell, 130, pp.456~469 (2007)
  26. Mauro, L. J., "Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation", J. Biol. Chem., 269, pp.30659~30667 (1994)
  27. Dacquin, R., "Knock-in of nuclear localised betagalactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar", Dev. Dyn., 229, pp.826~834 (2004)
  28. Ferron, M., "An ELISA-based method to quantify osteocalcin carboxylation in mice", Biochem. Biophys. Res. Commun. (2010)
  29. Ferron, M., "Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice", Proc. Natl. Acad. Sci. U.S.A., 통권 : 105, pp.5266~5270 (2008)
  30. Yoshizawa, T., "The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts", J. Clin. Invest., 119, pp.2807~2817 (2009)
  31. Rached, M. T., "FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice", J. Clin. Invest., 120, pp.357~368 (2010)
  32. Yang, X., "ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome", Cell, 117, pp.387~398 (2004)
  33. Accili, D., "FoxOs at the crossroads of cellular metabolism, differentiation, and transformation", Cell, 117, pp.421~426 (2004)
  34. Nakae, J., "Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1", Nat. Genet., 32, pp.245~253 (2002)
  35. Matsumoto, M., "Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver", Cell Metab., 6, pp.208~216 (2007)
  36. Nakae, J., "The forkhead transcription factor Foxo1 regulates adipocyte differentiation", Dev. Cell., 7, pp.119~129 (2003)
  37. Rached, M. T., "FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice", J. Clin. Invest., 120, pp.357~368 (2010)
  38. Hinoi, E., "The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity", J. Cell Biol., 183, pp.1235~1242 (2008)
  39. Morioka, T., "Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice", J. Clin. Invest., 117, pp.2860~2868 (2007)
  40. Takeda, S., "Leptin regulates bone formation via the sympathetic nervous system", Cell, 111, pp.305~317 (2002)
  41. Hinoi, E., "An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion", Ann. N. Y. Acad. Sci., 1173, pp.E20~E30 (2009)
  42. Hwang, Y. C., "The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects", Diabetes Metab. Res. Rev., 25, pp.768~772 (2009)
  43. Winhofer, Y., "Osteocalcin is related to enhanced insulin secretion in gestational diabetes mellitus", Diabetes Care, 33, pp.139~143 (2010)
  44. Pittas, A. G., "Association between serum osteocalcin and markers of metabolic phenotype", J. Clin. Endocrinol. Metab., 94, pp.827~832 (2009)

이 간행물의 다른 논문 (9건)