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MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN

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초록

HER2-overexpressing breast cancers are characterized byfrequent distant metastasis and often develop resistance aftershort-term effective treatment with the monoclonal antibodydrug, trastuzumab. Here, we found that the oncogenic miRNA,miR-221, inhibited apoptosis, induced trastuzumab resistanceand promoted metastasis of HER2-positive breast cancers. Thetumor suppressor PTEN was identified as a miR-221 target;overexpression of PTEN abrogated the aforementionedmiR-221-induced malignant phenotypes of the cells. Thesefindings indicate that miR-221 may promote trastuzumabresistance and metastasis of HER2-positive breast cancers bytargeting PTEN, suggesting its role as a potential biomarker forprogression and poor prognosis, and as a novel target fortrastuzumab-combined treatment of breast cancers.

Abstract

HER2-overexpressing breast cancers are characterized byfrequent distant metastasis and often develop resistance aftershort-term effective treatment with the monoclonal antibodydrug, trastuzumab. Here, we found that the oncogenic miRNA,miR-221, inhibited apoptosis, induced trastuzumab resistanceand promoted metastasis of HER2-positive breast cancers. Thetumor suppressor PTEN was identified as a miR-221 target;overexpression of PTEN abrogated the aforementionedmiR-221-induced malignant phenotypes of the cells. Thesefindings indicate that miR-221 may promote trastuzumabresistance and metastasis of HER2-positive breast cancers bytargeting PTEN, suggesting its role as a potential biomarker forprogression and poor prognosis, and as a novel target fortrastuzumab-combined treatment of breast cancers.

참고문헌 (28)

  1. Andersson, J., "A population-based study on the first forty-eight breast cancer patients receiving trastuzumab (Herceptin) on a named patient basis in Sweden", Acta. Oncol, 41, pp.276~281 (2002)
  2. Cobleigh, M. A., "Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease", J. Clin. Oncol, 17, pp.2639~2648 (1999)
  3. Slamon, D. J., "Human breast cancer: correlation of relapse and survival with amplification of the HER-2", neu oncogene, 1987, pp.235, 177~182
  4. Slamon, D. J., "Studies of the HER-2", neu proto-oncogene in human breast and ovarian cancer, 1989, pp.244, 707~712
  5. Owens, M. A., "HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues", Clin. Breast Cancer, 5, pp.63~69 (2004)
  6. Ross, J. S, "Targeted therapy in breast cancer: The HER-2", neu gene and protein, 2004, pp.3, 379~398
  7. Baselga, J., "Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2", neu-overexpressing metastatic breast cancer, 1996, pp.14, 737~744
  8. Menard, S., "HER2 as a prognostic factor in breast cancer", Oncology, 61(Suppl 2), pp.67~72 (2001)
  9. Press, M. F., "HER-2", neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas, 1997, pp.15, 2894~2904
  10. Bartel, D. P., "MicroRNAs: genomics, biogenesis, mechanism, and function", Cell, 116, pp.281~297 (2004)
  11. Ahmad, A., "Phosphoglucose isomerase", autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells, 2011, pp.71, 3400~3409
  12. Adams, B. D., "Involvement of microRNAs in breast cancer", Semin. Reprod. Med, 26, pp.522~536 (2008)
  13. Zhang, C. Z., "Inhibitory effect of knocking down microRNA-221 and microRNA-222 on glioma cell growth in vitro and in vivo", Zhonghua Zhong Liu Za Zhi, 31, pp.721~726 (2009)
  14. Galardi, S., "miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1", J. Biol. Chem, 282, pp.23716~23724 (2007)
  15. Zhang, C. Z., "MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN", BMC Cancer, 10, pp.367~ (2010)
  16. Felicetti, F., "The promyelocytic leukemia zinc finger microRNA-221", 222 pathway controls melanoma progression through multiple oncogenic mechanisms, 2008, pp.68, 2745~2754
  17. Rao, X., "MicroRNA-221", 222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways, 2011, pp.30, 1082~1097
  18. Thompson, C., "Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex", Mol. Cancer, 10, pp.62~79 (2011)
  19. Miller, T. W., "Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer", Breast Cancer Research, 13, pp.224~ (2011)
  20. Hollander, M. C., "PTEN loss in the continuum of common cancers, rare syndromes and mouse models", Nat. Rev. Cancer, 11, pp.289~301 (2011)
  21. O'Brien, N. A., "Activated phosphoinositide 3-Kinase", AKT signaling confers resistance to trastuzumab but not lapatinib mol, 2010, pp.9, 1489~1502
  22. Li, J., "Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells", Mol. Cell Biochem, 357(1-2), pp.31~38 (2011)
  23. Liu, Z. L., "MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radio resistance in non-small cell lung cancer cells by targeting PTEN", Mol. Cell Biochem, 372, pp.35~45 (2013)
  24. Wu, Z., "Upregulation of miR-153 promotes cell proliferation via downregulation of the PTEN tumor suppressor gene in human prostate cancer", Prostate, 73, pp.596~604 (2013)
  25. Eccles, S. A., "The role of c-erbB-2", HER2, J. Mammary Gland Biol. Neoplasia, pp.2002, 6[DOI]
  26. Esteva, F. J., "Molecular prognostic factors for breast cancer metastases and survival", Sem. Radiat. Oncol, 12, pp.319~328 (2002)
  27. Garofalo, M., "miR-221 & 222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation", Cancer Cell, 16, pp.498~509 (2009)
  28. Johanna, C. B., "Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma", Cancer, 97, pp.2972~2977 (2003)

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