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논문KCI 등재

Integrin activation

Mark H. Ginsberg
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2014.12|BMB Reports|제47권 제12호|pp. 655-659

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참고문헌

키워드

Cell adhesionSignal transductionIntegrinNanodiscTalinTransmembrane domain
주제분류화학

초록

Integrin-mediated cell adhesion is important for development,immune responses, hemostasis and wound healing. Integrinsalso function as signal transducing receptors that can controlintracellular pathways that regulate cell survival, proliferation,and cell fate. Conversely, cells can modulate the affinity of integrinsfor their ligands a process operationally defined as integrinactivation. Analysis of activation of integrins has nowprovided a detailed molecular understanding of this uniqueform of “inside-out” signal transduction and revealed newparadigms of how transmembrane domains (TMD) can transmitlong range allosteric changes in transmembrane proteins. Here, we will review how talin and mediates integrin activationand how the integrin TMD can transmit these inside out signals.

Abstract

Integrin-mediated cell adhesion is important for development,immune responses, hemostasis and wound healing. Integrinsalso function as signal transducing receptors that can controlintracellular pathways that regulate cell survival, proliferation,and cell fate. Conversely, cells can modulate the affinity of integrinsfor their ligands a process operationally defined as integrinactivation. Analysis of activation of integrins has nowprovided a detailed molecular understanding of this uniqueform of “inside-out” signal transduction and revealed newparadigms of how transmembrane domains (TMD) can transmitlong range allosteric changes in transmembrane proteins. Here, we will review how talin and mediates integrin activationand how the integrin TMD can transmit these inside out signals.

참고문헌 (42)

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