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A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification

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Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. In this review, we propose a mechanism that controls GSCs and their cell fate through selective activation, repression and mobilization of the specific mRNAs. This mechanism is acutely controlled by known signal transduction pathways (e.g., Notch signaling and Ras-ERK MAPK signaling pathways) and P granule (analogous to mammalian germ granule)-associated mRNA regulators (FBF-1, FBF-2, GLD-1, GLD-2, GLD-3, RNP-8 and IFE-1). Importantly, all regulators are highly conserved in many multi-cellular animals. Therefore, GSCs from a simple animal may provide broad insight into vertebrate stem cells (e.g., hematopoietic stem cells) and their cell fate specification.

Abstract

Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. In this review, we propose a mechanism that controls GSCs and their cell fate through selective activation, repression and mobilization of the specific mRNAs. This mechanism is acutely controlled by known signal transduction pathways (e.g., Notch signaling and Ras-ERK MAPK signaling pathways) and P granule (analogous to mammalian germ granule)-associated mRNA regulators (FBF-1, FBF-2, GLD-1, GLD-2, GLD-3, RNP-8 and IFE-1). Importantly, all regulators are highly conserved in many multi-cellular animals. Therefore, GSCs from a simple animal may provide broad insight into vertebrate stem cells (e.g., hematopoietic stem cells) and their cell fate specification.

참고문헌 (48)

  1. Spradling A, "Germline stem cells", Cold Spring Harb Perspect Biol, 3, pp.a002642~ (2011)
  2. Datla US, "Role of PUF-8", PUF protein in stem cell control, sperm-oocyte decision, cell fate reprogramming, 2014, pp.10, 1306~1311
  3. Robert A. Kobet, "Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification", Biomolecules & Therapeutics, 22(5), pp.371~383 (2014), 한국응용약물학회
  4. Kimble J, "Controls of germline stem cells, entry into meiosis, and the sperm", oocyte decision in Caenorhabditis elegans, 2007, pp.23, 405~433
  5. Kimble J, "Controls of germline stem cells, entry into meiosis, , the sperm", oocyte decision in Caenorhabditis elegans, 2007, pp.23, 405~433
  6. Byrd DT, "Scratching the niche that controls Caenorhabditis elegans germline stem cells", Semin Cell Dev Biol, 20, pp.1107~1113 (2009)
  7. Angelo G, "Starvation protects germline stem cells, extends reproductive longevity in C. elegans", Science, 326, pp.954~958 (2009)
  8. Crittenden SL, "A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans", Nature, 417, pp.660~666 (2002)
  9. Morgan CT, "Mitosis-meiosis, sperm-oocyte fate decisions are separable regulatory events", Proc Natl Acad Sci U S A, 110, pp.3411~3416 (2013)
  10. Wong MD, "Molecular mechanisms of germline stem cell regulation", Annu Rev Genet, 39, pp.173~195 (2005)
  11. Austin J, "Transcript analysis of glp-1and lin-12, homologous genes required for cell interactions during development of C. elegans", Cell, 58, pp.565~571 (1989)
  12. Yochem J, "glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins", Cell, 58, pp.553~563 (1989)
  13. Crittenden SL, "Genes required for GLP-1 asymmetry in the early Caenorhabditis elegans embryo", Dev Biol, 181, pp.36~46 (1997)
  14. Crittenden SL, "Regulation of the mitosis", meiosis decision in the Caenorhabditis elegans germline, 2003, pp.358, 1359~1362
  15. Kershner AM, "Discovery of two GLP-1", Notch target genes that account for the role of GLP-1, Proc Natl Acad Sci U S A, pp.2014, 111[DOI]
  16. Lamont LB, "FBF-1, FBF-2 regulate the size of the mitotic region in the C. elegans germline", Dev Cell, 7, pp.697~707 (2004)
  17. Lee MH, "LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans", EMBO J, 25, pp.88~96 (2006)
  18. Hajnal A, "The C. elegans MAPK phosphatase LIP-1 is required for the G(2)", M meiotic arrest of developing oocytes, 2002, pp.21, 4317~4326
  19. Voronina E, "The P granule component PGL-1 promotes the localization, silencing activity of the PUF protein FBF-2 in germline stem cells", Development, 139, pp.3732~3740 (2012)
  20. Kershner AM, "Genome-wide analysis of mRNA targets for Caenorhabditis elegans FBF, a conserved stem cell regulator", Proc Natl Acad Sci U S A, 107, pp.3936~3941 (2010)
  21. Lee MH, "Conserved regulation of MAP kinase expression by PUF RNA-binding proteins", PLoS Genet, 3, pp.e233~ (2007)
  22. Friend K, "A conserved PUF–Ago–eEF1A complex attenuates translation elongation", Nat Struct Mol Biol, 19, pp.176~183 (2012)
  23. Goldstrohm AC, "PUF proteins bind Pop2p to regulate messenger RNAs", Nat Struct Mol Biol, 13, pp.533~539 (2006)
  24. Whelan JT, "Post-transcriptional regulation of the Ras-ERK", MAPK signaling pathway, 2012, pp.227, 1235~1241
  25. Millonigg S, "GLD-4-mediated translational activation regulates the size of the proliferative germ cell pool in the adult C. elegans germ line", PLoS Genet, 10, pp.e1004647~ (2014)
  26. Eckmann CR, "GLD-3, a bicaudal-C homolog that inhibits FBF to control germline sex determination in C. elegans", Dev Cell, 3, pp.697~710 (2002)
  27. Lee MH, "Phosphorylation state of a Tob", BTG protein, FOG-3, regulates initiation, maintenance of the Caenorhabditis elegans sperm fate program, 2011, pp.108, 9125~9130
  28. Thompson BE, "Dose-dependent control of proliferation, sperm specification by FOG-1", CPEB, 2005, pp.132, 3471~3481
  29. Arur S, "MPK-1 ERK controls membrane organization in C. elegans oogenesis via a sex-determination module", Dev Cell, 20, pp.677~688 (2011)
  30. Kershner A, "Germline stem cells, their regulation in the nematode Caenorhabditis elegans", Adv Exp Med Biol, 786, pp.29~46 (2013)
  31. Morgan CT, "Chemical reprogramming of Caenorhabditis elegans germ cell fate", Nat Chem Biol, 6, pp.102~104 (2010)
  32. Ellis RE, "The fog-3 gene, regulation of cell fate in the germ line of Caenorhabditis elegans", Genetics, 139, pp.561~577 (1995)
  33. Snow JJ, "C. elegans FOG-3", Tob can either promote or inhibit germline proliferation, depending on gene dosage, genetic context, 2013, pp.32, 2614~2621
  34. Morgan DE, "The C. elegans adult male germline: stem cells, sexual dimorphism", Dev Biol, 346, pp.204~214 (2010)
  35. Suh N, "The GLD-2 poly(A)polymerase activates gld-1mRNA in the Caenorhabditis elegans germ line", Proc Natl Acad Sci U S A, 103, pp.15108~15112 (2006)
  36. Kadyk LC, "Genetic regulation of entry into meiosis in Caenorhabditis elegans", Development, 125, pp.1803~1813 (1998)
  37. Wang L, "A regulatory cytoplasmic poly(A)polymerase in Caenorhabditis elegans", Nature, 419, pp.312~316 (2002)
  38. Kim KW, "Antagonism between GLD-2 binding partners controls gamete sex", Dev Cell, 16, pp.723~733 (2009)
  39. Kim KW, "GLD-2", RNP-8cytoplasmic poly(A)polymerase is a broad-spectrum regulator of the oogenesis program, 2010, pp.107, 17445~17450
  40. Henderson MA, "A germline-specific isoform of eIF4E(IFE-1)is required for efficient translation of stored mRNAs, maturation of both oocytes, sperm", J Cell Sci, 122, pp.1529~1539 (2009)
  41. Amiri A, "An isoform of eIF4E is a component of germ granules, is required for spermatogenesis in C. elegans", Development, 128, pp.3899~3912 (2001)
  42. Clifford R, "FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein, directs male sex determination in the C. elegans hermaphrodite germline", Development, 127, pp.5265~5276 (2000)
  43. Suh N, "FBF, its dual control of gld-1 expression in the Caenorhabditis elegans germline", Genetics, 181, pp.1249~1260 (2009)
  44. Updike D, "P granule assembly, function in Caenorhabditis elegans germ cells", J Androl, 31, pp.53~60 (2010)
  45. Sengupta MS, "Germ granules, the control of mRNA translation", IUBMB Life, 64, pp.586~594 (2012)
  46. Wickens M, "A PUF family portrait: 3'UTR regulation as a way of life", Trends Genet, 18, pp.150~157 (2002)
  47. Moore FL, "Human Pumilio-2 is expressed in embryonic stem cells, germ cells, interacts with DAZ(Deleted in AZoospermia)and DAZ-like proteins", Proc Natl Acad Sci U S A, 100, pp.538~543 (2003)
  48. Spassov DS, "Mouse Pum1, Pum2genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal, adult hematopoietic stem cells, progenitors", Blood Cells Mol Dis, 30, pp.55~69 (2003)

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