MiR-363 inhibits cisplatin chemoresistance of epithelial ovarian cancer by regulating snail-induced epithelial-mesenchymal transition
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Chemoresistance is a major barrier to successful cisplatinbased chemotherapy for epithelial ovarian cancer (EOC), and emerging evidences suggest that microRNAs (miRNAs) are involved in the resistance. In this study, it was indicated that miR-363 downregulation was significantly correlated with EOC carcinogenesis and cisplatin resistance. Moreover, miR-363 overexpression could resensitise cisplatin-resistant EOC cells to cisplatin treatment both in vitro and in vivo. In addition, data revealed that EMT inducer Snail was significantly upregulated in cisplatin-resistant EOC cell lines and EOC patients and was a functional target of miR-363 in EOC cells. Furthermore, snail overexpression could significantly attenuate miR-363-suppressed cisplatin resistance of EOC cells, suggesting that miR-363-regulated cisplatin resistance is mediated by snail-induced EMT in EOC cells. Taken together, findings suggest that miR-363 may be a biomarker for predicting responsiveness to cisplatin-based chemotherapy and a potential therapeutic target in EOC.
Abstract
Chemoresistance is a major barrier to successful cisplatinbased chemotherapy for epithelial ovarian cancer (EOC), and emerging evidences suggest that microRNAs (miRNAs) are involved in the resistance. In this study, it was indicated that miR-363 downregulation was significantly correlated with EOC carcinogenesis and cisplatin resistance. Moreover, miR-363 overexpression could resensitise cisplatin-resistant EOC cells to cisplatin treatment both in vitro and in vivo. In addition, data revealed that EMT inducer Snail was significantly upregulated in cisplatin-resistant EOC cell lines and EOC patients and was a functional target of miR-363 in EOC cells. Furthermore, snail overexpression could significantly attenuate miR-363-suppressed cisplatin resistance of EOC cells, suggesting that miR-363-regulated cisplatin resistance is mediated by snail-induced EMT in EOC cells. Taken together, findings suggest that miR-363 may be a biomarker for predicting responsiveness to cisplatin-based chemotherapy and a potential therapeutic target in EOC.
참고문헌 (31)
- Chiu WT, "FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells", Oncotarget, 6, pp.2349~2365 (2015)
- Kuchenbaecker KB, "Identification of six new susceptibility loci for invasive epithelial ovarian cancer", Nat Genet, 47, pp.164~171 (2015)[DOI]
- Raghavan R, "Drug discovery using clinical outcome-based Connectivity Mapping: application to ovarian cancer", BMC Genomics, 17, pp.811~ (2016)[DOI]
- Siddik ZH, "Cisplatin: mode of cytotoxic action and molecular basis of resistance", Oncogene, 22, pp.7265~7279 (2003)[DOI]
- Zamble DB, "Cisplatin and DNA repair in cancer chemotherapy", Trends Biochem Sci, 20, pp.435~439 (1995)[DOI]
- Siegel R, "Cancer statistics for Hispanics", Latinos, 2012, 2012, pp.62, 283~298
- Polyak K, "Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits", Nat Rev Cancer, 9, pp.265~273 (2009)[DOI]
- Marchini S, "Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer", Eur J Cancer, 49, pp.520~530 (2013)[DOI]
- Calin GA, "MicroRNA signatures in human cancers", Nat Rev Cancer, 6, pp.857~866 (2006)[DOI]
- Chang TC, "Widespread microRNA repression by Myc contributes to tumorigenesis", Nat Genet, 40, pp.43~50 (2008)[DOI]
- Johnson CD, "The let-7 microRNA represses cell proliferation pathways in human cells", Cancer Res, 67, pp.7713~7722 (2007)[DOI]
- Tsai WC, "MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis", J Clin Invest, 122, pp.2884~2897 (2012)[DOI]
- Liu J, "MicroRNA-363-3p inhibits papillary thyroid carcinoma progression by targeting PIK3CA", Am J Cancer Res, 7, pp.148~158 (2017)
- Zhang PF, "miR-363 promotes proliferation and chemo-resistance of human gastric cancer via targeting of FBW7 ubiquitin ligase expression", Oncotarget, 7, pp.35284~35292 (2016)
- Hu F, "MiR-363-3p inhibits the epithelial-to-mesenchymal transition and suppresses metastasis in colorectal cancer by targeting Sox4", Biochem Biophys Res Commun, 474, pp.35~42 (2016)[DOI]
- Zhang R, "MiR-363 sensitizes cisplatin-induced apoptosis targeting in Mcl-1 in breast cancer", Med Oncol, 31, pp.347~ (2014)[DOI]
- Li Y, "Oncogenic cAMP responsive element binding protein 1 is overexpressed upon loss of tumor suppressive miR-10b-5p and miR-363-3p in renal cancer", Oncol Rep, 35, pp.1967~1978 (2016)[DOI]
- Chen Y, "MicroRNA 363 mediated positive regulation of c-myc translation affect prostate cancer development and progress", Neoplasma, 62, pp.191~198 (2015)[DOI]
- Conti A, "MiRNA expression profiling in human gliomas: upregulated miR-363 increases cell survival and proliferation", Tumour Biol, 37, pp.14035~14048 (2016)[DOI]
- Lin Y, "MicroRNA-363 inhibits ovarian cancer progression by inhibiting NOB1", Oncotarget, 8, pp.101649~101658 (2017)
- Huang H, "LncRNA NR2F1-AS1 regulates hepatocellular carcinoma oxaliplatin resistance by targeting ABCC1 via miR-363", J Cell Mol Med, 22, pp.3238~3245 (2018)[DOI]
- Zhang P, "Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer", Cell Death Dis, 5, pp.e991~ (2014)[DOI]
- Boyerinas B, "Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1", Int J Cancer, 130, pp.1787~1797 (2012)[DOI]
- Chin LJ, "A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk", Cancer Res, 68, pp.8535~8540 (2008)[DOI]
- Liu C, "Distinct microRNA expression profiles in prostate cancer stem", progenitor cells and tumor-suppressive functions of let-7, 2012, pp.72, 3393~3404
- Yu F, "let-7 regulates self renewal and tumorigenicity of breast cancer cells", Cell, 131, pp.1109~1123 (2007)[DOI]
- Cai J, "Deregulation of let-7e in epithelial ovarian cancer promotes the development of resistance to cisplatin", Oncogenesis, 2, pp.e75~ (2013)[DOI]
- Hsu DS, "Regulation of excision repair cross-complementation group 1 by Snail contributes to cisplatin resistance in head and neck cancer", Clin Cancer Res, 16, pp.4561~4571 (2010)[DOI]
- Kaufhold S, "Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention", J Exp Clin Cancer Res, 33, pp.62~ (2014)[DOI]
- Haslehurst AM, "EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer", BMC Cancer, 12, pp.91~ (2012)[DOI]
- Zhuo W, "Knockdown of Snail, a novel zinc finger transcription factor, via RNA interference increases A549 cell sensitivity to cisplatin via JNK", mitochondrial pathway, 2008, pp.62, 8~14
