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Stem cells and reproduction

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주제분류화학

초록

Reproductive biotechnology has developed rapidly and is now able to overcome many birth difficulties due to infertility or the transmission of genetic diseases. Here we introduce the next generation of assisted reproductive technologies (ART), such as mitochondrial replacement technique (MRT) or genetic correction in eggs with micromanipulation. Further, we suggest that the transmission of genetic information from somatic cells to subsequent generations without gametes should be useful for people who suffer from infertility or genetic diseases. Pluripotent stem cells (PSCs) can be converted into germ cells such as sperm or oocytes in the laboratory. Notably, germ cells derived from nuclear transfer embryonic stem cells (NT-ESCs) or induced pluripotent stem cells (iPSCs) inherit the full parental genome. The most important issue in this technique is the generation of a haploid chromosome from diploid somatic cells. We hereby examine current science and limitations underpinning these important developments and provide recommendations for moving forward.

Abstract

Reproductive biotechnology has developed rapidly and is now able to overcome many birth difficulties due to infertility or the transmission of genetic diseases. Here we introduce the next generation of assisted reproductive technologies (ART), such as mitochondrial replacement technique (MRT) or genetic correction in eggs with micromanipulation. Further, we suggest that the transmission of genetic information from somatic cells to subsequent generations without gametes should be useful for people who suffer from infertility or genetic diseases. Pluripotent stem cells (PSCs) can be converted into germ cells such as sperm or oocytes in the laboratory. Notably, germ cells derived from nuclear transfer embryonic stem cells (NT-ESCs) or induced pluripotent stem cells (iPSCs) inherit the full parental genome. The most important issue in this technique is the generation of a haploid chromosome from diploid somatic cells. We hereby examine current science and limitations underpinning these important developments and provide recommendations for moving forward.

참고문헌 (80)

  1. Sherrod RA, "Understanding the emotional aspects of infertility : Implications for nursing practice", J Psychosoc Nurs Ment Health Serv, 42, pp.40~47 (2004)
  2. Boulet SL, "Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection", JAMA, 313, pp.255~263 (2015)
  3. Verhaak CM, "Women's emotional adjustment to IVF : A systematic review of 25 years of research", Hum Reprod Update, 13, pp.27~36 (2007)
  4. Maleki-Saghooni N, "Effectiveness of infertility counseling on pregnancy rate in infertile patients undergoing assisted reproductive technologies: A systematic review and meta-analysis", Int J Reprod Biomed (Yazd), 15, pp.391~402 (2017)
  5. Edwards RG, "Establishing full-term human pregnancies using cleaving embryos grown in vitro", Br J Obstet Gynaecol, 87, pp.737~756 (1980)
  6. Devroey P, "A review of ten years experience of ICSI", Hum Reprod Update, 10, pp.19~28 (2004)
  7. Palermo G, "Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte", Lancet, 340, pp.17~18 (1992)
  8. Zegers-Hochschild F, "The international glossary on infertility and fertility care", Fertil Steril, 108, pp.393~406 (2017)
  9. Vaiarelli A, "Pre-implantation genetic testing in ART: Who will benefit and what is the evidence?", J Assist Reprod Genet, 33, pp.1273~1278 (2016)
  10. Lee HS, "Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck", Cell Rep, 1, pp.506~515 (2012)
  11. Steffann J, "Analysis of mtDNA variant segregation during early human embryonic development : A tool for successful NARP preimplantation diagnosis", J Med Genet, 43, pp.244~247 (2006)
  12. Wolf DP, "Mitochondrial replacement therapy in reproductive medicine", Trends Mol Med, 21, pp.68~76 (2015)
  13. Tachibana M, "Mitochondrial replacement therapy and assisted reproductive technology : A paradigm shift toward treatment of genetic diseases in gametes or in early embryos", Reprod Med Biol, 17, pp.421~433 (2018)
  14. McGrath J, "Nuclear transplantation in the mouse embryo by microsurgery and cell fusion", Science, 220, pp.1300~1302 (1983)
  15. Hyslop LA, "Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease", Nature, 534, pp.383~386 (2016)
  16. Tachibana M, "Mitochondrial gene replacement in primate offspring and embryonic stem cells", Nature, 461, pp.367~372 (2009)
  17. Tachibana M, "Towards germline gene therapy of inherited mitochondrial diseases", Nature, 493, pp.627~631 (2013)
  18. Kang E, "Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations", Nature, 540, pp.270~275 (2016)
  19. Zhang J, "Live birth derived from oocyte spindle transfer to prevent mitochondrial disease", Reprod Biomed Online, 34, pp.361~368 (2017)
  20. Wakayama T, "The first polar body can be used for the production of normal offspring in mice", Biol Reprod, 59, pp.100~104 (1998)
  21. Wakayama T, "Participation of the female pronucleus derived from the second polar body in full embryonic development of mice", J Reprod Fertil, 110, pp.263~266 (1997)
  22. Ma H, "Functional human oocytes generated by transfer of polar body genomes", Cell Stem Cell, 20, pp.112~119 (2017)
  23. "Reproduction and fertility: How could stem cells help?"[URL]
  24. Hayashi K, "Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells", Cell, 146, pp.519~532 (2011)
  25. Hayashi K, "Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice", Science, 338, pp.971~975 (2012)
  26. Hikabe O, "Reconstitution in vitro of the entire cycle of the mouse female germ line", Nature, 539, pp.299~303 (2016)
  27. Zhou Q, "Complete meiosis from embryonic stem cell-derived germ cells in vitro", Cell Stem Cell, 18, pp.330~340 (2016)
  28. Sun M, "Efficient generation of functional haploid spermatids from human germline stem cells by three-dimensional-induced system", Cell Death Differ, 25, pp.747~764 (2018)
  29. Yamashiro C, "Generation of human oogonia from induced pluripotent stem cells in vitro", Science, 362, pp.356~360 (2018)
  30. Jung D, "In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells", Nat Commun, 8, pp.15680~ (2017)
  31. Rathjen J, "Formation of a primitive ectoderm like cell population, EPL cells, from ES cells in response to biologically derived factors", J Cell Sci, 112(Pt 5), pp.601~612 (1999)
  32. Tesar PJ, "New cell lines from mouse epiblast share defining features with human embryonic stem cells", Nature, 448, pp.196~199 (2007)
  33. Brons IG, "Derivation of pluripotent epiblast stem cells from mammalian embryos", Nature, 448, pp.191~195 (2007)
  34. Hayashi M, "Generation of germ cells from pluripotent stem cells in mammals", Reprod Med Biol, 17, pp.107~114 (2017)
  35. Ma H, "Correction of a pathogenic gene mutation in human embryos", Nature, 548, pp.413~419 (2017)
  36. Zhang C, "Development and application of CRISPR", Cas9 technologies in genomic editing, 2018, pp.27, R79~R88
  37. Tang L, "CRISPR", Cas9-mediated gene editing in human zygotes using Cas9 protein, 2017, pp.292, 525~533
  38. Kang X, "Introducing precise genetic modifications into human 3PN embryos by CRISPR", cas-mediated genome editing, 2016, pp.33, 581~588
  39. Liang P, "Correction of beta-thalassemia mutant by base editor in human embryos", Protein Cell, 8, pp.811~822 (2017)
  40. Zhou C, "Highly efficient base editing in human tripronuclear zygotes", Protein Cell, 8, pp.772~775 (2017)
  41. Evans MJ, "Establishment in culture of pluripotential cells from mouse embryos", Nature, 292, pp.154~156 (1981)
  42. Thomson JA, "Embryonic stem cell lines derived from human blastocysts", Science, 282, pp.1145~1147 (1998)
  43. Daughtry B, "Concise review : Parthenote stem cells for regenerative medicine : Genetic, epigenetic, and developmental features", Stem Cells Transl Med, 3, pp.290~298 (2014)
  44. Thomson JA, "Isolation of a primate embryonic stem cell line", Proc Natl Acad Sci U S A, 92, pp.7844~7848 (1995)
  45. Wolf DP, "Concise review:Embryonic stem cells derived by somatic cell nuclear transfer: A horse in the race?", Stem Cells, 35, pp.26~34 (2017)
  46. Takahashi K, "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors", Cell, 126, pp.663~676 (2006)
  47. Okita K, "Generation of germline-competent induced pluripotent stem cells", Nature, 448, pp.313~317 (2007)
  48. Takahashi K, "Induction of pluripotent stem cells from adult human fibroblasts by defined factors", Cell, 131, pp.861~872 (2007)
  49. Ma H, "Abnormalities in human pluripotent cells due to reprogramming mechanisms", Nature, 511, pp.177~183 (2014)
  50. Yamada M, "Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells", Nature, 510, pp.533~536 (2014)
  51. Matoba S, "Somatic cell nuclear transfer reprogramming : Mechanisms and applications", Cell Stem Cell, 23, pp.471~485 (2018)
  52. GURDON JB, "The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles", J Embryol Exp Morphol, 10, pp.622~640 (1962)
  53. Thuan NV, "How to improve the success rate of mouse cloning technology", J Reprod Dev, 56, pp.20~30 (2010)
  54. Inoue K, "Effects of donor cell type and genotype on the efficiency of mouse somatic cell cloning", Biol Reprod, 69, pp.1394~1400 (2003)
  55. Wakayama S, "Establishment of male and female nuclear transfer embryonic stem cell lines from different mouse strains and tissues", Biol Reprod, 72, pp.932~936 (2005)
  56. Tachibana M, "Human embryonic stem cells derived by somatic cell nuclear transfer", Cell, 153, pp.1228~1238 (2013)
  57. Chung YG, "Human somatic cell nuclear transfer using adult cells", Cell Stem Cell, 14, pp.777~780 (2014)
  58. Ziller MJ, "Genomic distribution and inter-sample variation of non-CpG methylation across human cell types", PLoS Genet, 7, pp.e1002389~ (2011)
  59. Dinger TC, "Androgenetic embryonic stem cells form neural progenitor cells in vivo and in vitro", Stem Cells, 26, pp.1474~1483 (2008)
  60. Mitalipov SM, "Parthenogenetic activation of rhesus monkey oocytes and reconstructed embryos", Biol Reprod, 65, pp.253~259 (2001)
  61. Tarkowski AK, "Experimental partheonogenesis in the mouse", Nature, 226, pp.162~165 (1970)
  62. Chen Z, "Birth of parthenote mice directly from parthenogenetic embryonic stem cells", Stem Cells, 27, pp.2136~2145 (2009)
  63. Sritanaudomchai H, "Discovery of a novel imprinted gene by transcriptional analysis of parthenogenetic embryonic stem cells", Hum Reprod, 25, pp.1927~1941 (2010)
  64. Yang H, "Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells", Cell, 149, pp.605~617 (2012)
  65. Li W, "Androgenetic haploid embryonic stem cells produce live transgenic mice", Nature, 490, pp.407~411 (2012)
  66. Ding C, "Derivation of a homozygous human androgenetic embryonic stem cell line", Stem Cells Dev, 24, pp.2307~2316 (2015)
  67. Paffoni A, "Parthenogenetic activation: Biology and applications in the ART laboratory", Placenta, 29(Suppl B), pp.121~125 (2008)
  68. Graham CF, "The production of parthenogenetic mammalian embryos and their use in biological research", Biol Rev Camb Philos Soc, 49, pp.399~424 (1974)
  69. Leeb M, "Derivation of haploid embryonic stem cells from mouse embryos", Nature, 479, pp.131~134 (2011)
  70. Wutz A, "Haploid mouse embryonic stem cells : Rapid genetic screening and germline transmission", Annu Rev Cell Dev Biol, 30, pp.705~722 (2014)
  71. Ford CE, "A functional 'sex-reversed' oocyte in the mouse", Proc R Soc Lond B Biol Sci, 190, pp.187~197 (1975)
  72. Hubner K, "Derivation of oocytes from mouse embryonic stem cells", Science, 300, pp.1251~1256 (2003)
  73. Qing T, "Induction of oocyte-like cells from mouse embryonic stem cells by co-culture with ovarian granulosa cells", Differentiation, 75, pp.902~911 (2007)
  74. Taketo T, "The role of sex chromosomes in mammalian germ cell differentiation: Can the germ cells carrying X and Y chromosomes differentiate into fertile oocytes?", Asian J Androl, 17, pp.360~366 (2015)
  75. Tsai MC, "Alternative sources of gametes:Reality or science fiction?", Hum Reprod, 15, pp.988~998 (2000)
  76. Fulka J Jr, "Somatic and embryonic cell nucleus transfer into intact and enucleated immature mouse oocytes", Hum Reprod, 17, pp.2160~2164 (2002)
  77. Tesarik J, "Fertilizable oocytes reconstructed from patient's somatic cell nuclei and donor ooplasts", Reprod Biomed Online, 2, pp.160~164 (2001)
  78. Halley-Stott RP, "Epigenetic memory in the context of nuclear reprogramming and cancer", Brief Funct Genomics, 12, pp.164~173 (2013)
  79. Maherali N, "Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution", Cell Stem Cell, 1, pp.55~70 (2007)
  80. Marcin Samiec MS, "Can reprogramming of overall epigenetic memory and specific parental genomic imprinting memory within donor cell-inherited nuclear genome be a major hindrance for the somatic cell cloning of mammals? – A review", Annals of Animal Science (Ann Anim Sci), 18, pp.623~638 (2018)

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