Effects of chronic alcohol consumption on expression levels of APP and Aβ-producing enzymes
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Chronic alcohol consumption contributes to numerous diseases,including cancers, cardiovascular diseases, and liver cirrhosis. Epidemiological studies have shown that excessive alcohol consumption is a risk factor for dementia. Along this line, Alzheimer’s disease (AD) is the most common form of dementia and is caused by the accumulation of amyloid-β (Aβplaques in neurons. In this study, we hypothesized that chronic ethanol consumption is associated with pathological processing of APP in AD. To investigate the relationship between chronic alcohol consumption and Aβ production, brain samples from rats fed an alcohol liquid diet for 5 weeks were analyzed. We show that the expression levels of APP, BACE1,and immature nicastrin were increased in the cerebellum, hippocampus,and striatum of the alcohol-fed group compared to the control group. Total nicastrin and PS1 levels were induced in the hippocampus of alcohol-fed rats. These data suggest that the altered expression of APP and Aβ-producing enzymes possibly contributes to the chronic alcohol consumption-mediated pathogenesis of AD. [BMB reports 2011; 44(2): 135-139]
Abstract
Chronic alcohol consumption contributes to numerous diseases,including cancers, cardiovascular diseases, and liver cirrhosis. Epidemiological studies have shown that excessive alcohol consumption is a risk factor for dementia. Along this line, Alzheimer’s disease (AD) is the most common form of dementia and is caused by the accumulation of amyloid-β (Aβplaques in neurons. In this study, we hypothesized that chronic ethanol consumption is associated with pathological processing of APP in AD. To investigate the relationship between chronic alcohol consumption and Aβ production, brain samples from rats fed an alcohol liquid diet for 5 weeks were analyzed. We show that the expression levels of APP, BACE1,and immature nicastrin were increased in the cerebellum, hippocampus,and striatum of the alcohol-fed group compared to the control group. Total nicastrin and PS1 levels were induced in the hippocampus of alcohol-fed rats. These data suggest that the altered expression of APP and Aβ-producing enzymes possibly contributes to the chronic alcohol consumption-mediated pathogenesis of AD. [BMB reports 2011; 44(2): 135-139]
참고문헌 (34)
- Kalaria, R. N, "Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors", Lancet Neurol, 7, pp.812~826 (2008)
- Tanzi, R. E, "Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective", Cell, 120, pp.545~555 (2005)
- Mattson, M. P, "Pathways towards and away from Alzheimer's disease", Nature, 430, pp.631~639 (2004)
- Gasior, M, "Neuroprotective and disease-modifying effects of the ketogenic diet", Behav. Pharmacol, 17, pp.431~439 (2006)
- Lau, F. C, "Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress", Subcell. Biochem, 42, pp.299~318 (2007)
- Dosunmu, R, "Environmental and dietary risk factors in Alzheimer's disease", Expert Rev. Neurother, 7, pp.887~900 (2007)
- Panza, F, "Alcohol use, thiamine deficiency, and cognitive impairment", JAMA, 299, pp.2853~2855 (2008)
- Ramesh, B. N, "Neuronutrition and Alzheimer's disease", J. Alzheimers. Dis, 19, pp.1123~1139
- Ruitenberg, A, "Alcohol consumption and risk of dementia: the Rotterdam Study", Lancet, 359, pp.281~286 (2002)
- Mukamal, K. J, "Prospective study of alcohol consumption and risk of dementia in older adults", JAMA, 289, pp.1405~1413 (2003)
- Galanis, D. J, "A longitudinal study of drinking and cognitive performance in elderly Japanese American men: the Honolulu-Asia Aging Study", Am. J. Public. Health, 90, pp.1254~1259 (2000)
- Luchsinger, J. A, "Cardiovascular risk factors and Alzheimer's disease", Curr. Atheroscler. Rep, 6, pp.261~266 (2004)
- Truelsen, T, "Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study", Neurology, 59, pp.1313~1319 (2002)
- Jaatinen, P, "Interaction of aging and intermittent ethanol exposure on brain cytochrome c oxidase activity levels", Alcohol, 29, pp.91~100 (2003)
- de la Monte, S. M, "Morphometric demonstration of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's disease", J. Neuropathol. Exp. Neurol, 47, pp.516~525 (1988)
- Mann, K, "Neuroimaging in alcoholism: ethanol and brain damage", Alcohol. Clin. Exp. Res, 25, pp.104S~109S (2001)
- Ferrer, I, "A Golgi study of cerebellar atrophy in human chronic alcoholism", Neuropathol. Appl. Neurobiol, 10, pp.245~253 (1984)
- Fox, J. H, "Cerebral ventricular enlargement. Chronic alcoholics examined by computerized tomography", JAMA, 236, pp.365~368 (1976)
- Sullivan, E. V, "Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics", Alcohol. Clin. Exp. Res, 19, pp.110~122 (1995)
- Bleich, S, "reduction and first-onset alcohol withdrawal seizure", A volumetric MRI study. Alcohol Alcohol, 38, pp.40~44 (2003)
- Kurth, C, "Analysis of hippocampal atrophy in alcoholic patients by a Kohonen feature map", Neuroreport, 15, pp.367~371 (2004)
- Bleich, S, "Apolipoprotein E epsilon 4 is associated with hippocampal volume reduction in females with alcoholism", J. Neural. Transm, 110, pp.401~411 (2003)
- Hommer, D, "Evidence for a gender-related effect of alcoholism on brain volumes", Am. J. Psychiatry, 158, pp.198~204 (2001)
- Pfefferbaum, A, "Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study", Alcohol. Clin. Exp. Res, 16, pp.1078~1089 (1992)
- Teichman, M, ""Dose", duration effect" relationship between alcohol consumption and cerebral atrophy: a psychological and neuroradiological evaluation, 1987, pp.13, 357~363
- Kril, J. J, "Neuronal changes in the cerebral cortex of the rat following alcohol treatment and thiamin deficiency", J. Neuropathol. Exp. Neurol, 52, pp.586~593 (1993)
- Woo, H. N, "Alzheimer's disease and Notch signaling", Biochem. Biophys. Res. Commun, 390, pp.1093~1097 (2009)
- Woo, H. N, "Secretases as therapeutic targets for Alzheimer's disease", Biochem. Biophys. Res. Commun (2011)[DOI]
- Jo, D. G, "Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease", NEUROBIOLOGY OF AGING, 31(6), pp.917~925 (2010), ELSEVIER SCIENCE INC
- Shah, S, "Nicastrin functions as a gamma-secretase-substrate receptor", Cell, 122, pp.435~447 (2005)
- Anttila, T, "Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study", BMJ, 329, pp.539~ (2004)
- Rothman, S. M, "Adverse stress, hippocampal networks, and Alzheimer's disease", Neuromolecular Med, 12, pp.56~70 (2010)
- Lieber, C. S, "Liquid diet technique of ethanol administration: 1989 update", Alcohol Alcohol, 24, pp.197~211 (1989)
- Kerai, M. D, "Reversal of ethanol-induced hepatic steatosis and lipid peroxidation by taurine: a study in rats", Alcohol Alcohol, 34, pp.529~541 (1999)