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논문KCI 등재

Ca²+-regulated ion channels

Daniel H. Cox
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2011.10|BMB Reports|제44권 제10호|pp. 635-646

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참고문헌

키워드

CalciumCalcium channelBK channelCalmodulinSK channel
주제분류화학

초록

Due to its high external and low internal concentration the Ca²+ ion is used ubiquitously as an intracellular signaling molecule,and a great many Ca²+-sensing proteins have evolved to receive and propagate Ca²+ signals. Among them are ion channel proteins, whose Ca²+ sensitivity allows internal Ca²+to influence the electrical activity of cell membranes and to feedback-inhibit further Ca²+ entry into the cytoplasm. In this review I will describe what is understood about the Ca²+ sensing mechanisms of the three best studied classes of Ca²+-sensitive ion channels: Large-conductance Ca²+-activated K+ channels,small-conductance Ca²+-activated K+ channels, and voltage-gated Ca²+ channels. Great strides in mechanistic understanding have be made for each of these channel types in just the past few years. [BMB reports 2011; 44(10): 635-646]

Abstract

Due to its high external and low internal concentration the Ca²+ ion is used ubiquitously as an intracellular signaling molecule,and a great many Ca²+-sensing proteins have evolved to receive and propagate Ca²+ signals. Among them are ion channel proteins, whose Ca²+ sensitivity allows internal Ca²+to influence the electrical activity of cell membranes and to feedback-inhibit further Ca²+ entry into the cytoplasm. In this review I will describe what is understood about the Ca²+ sensing mechanisms of the three best studied classes of Ca²+-sensitive ion channels: Large-conductance Ca²+-activated K+ channels,small-conductance Ca²+-activated K+ channels, and voltage-gated Ca²+ channels. Great strides in mechanistic understanding have be made for each of these channel types in just the past few years. [BMB reports 2011; 44(10): 635-646]

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