본문 바로가기
KERD
논문KCI 등재

KAREBrowser: SNP database of Korea Association REsource Project

2

조회

0

다운로드

3

인용

0

참고문헌

키워드

주제분류화학

초록

The International HapMap Project and the Human Genome Diversity Project (HGDP) provide plentiful resources on human genome information to the public. However, this kind of information is limited because of the small sample size in both databases. A Genome-Wide Association Study has been conducted with 8,842 Korean subjects as a part of the Korea Association Resource (KARE) project. In an effort to build a publicly available browsing system for genome data resulted from large scale KARE GWAS, we developed the KARE browser. This browser provides users with a large amount of single nucleotide polymorphisms (SNPs) information comprising 1.5 million SNPs from population-based cohorts of 8,842 samples. KAREBrowser was based on the generic genome browser (GBrowse), a webbased application tool developed for users to navigate and visualize the genomic features and annotations in an interactive manner. All SNP information and related functions are available at the web site http://ksnp.cdc. go.kr/karebrowser/. [BMB reports 2012; 45(1): 47-50]

Abstract

The International HapMap Project and the Human Genome Diversity Project (HGDP) provide plentiful resources on human genome information to the public. However, this kind of information is limited because of the small sample size in both databases. A Genome-Wide Association Study has been conducted with 8,842 Korean subjects as a part of the Korea Association Resource (KARE) project. In an effort to build a publicly available browsing system for genome data resulted from large scale KARE GWAS, we developed the KARE browser. This browser provides users with a large amount of single nucleotide polymorphisms (SNPs) information comprising 1.5 million SNPs from population-based cohorts of 8,842 samples. KAREBrowser was based on the generic genome browser (GBrowse), a webbased application tool developed for users to navigate and visualize the genomic features and annotations in an interactive manner. All SNP information and related functions are available at the web site http://ksnp.cdc. go.kr/karebrowser/. [BMB reports 2012; 45(1): 47-50]

참고문헌 (11)

  1. Thorisson, G. A., "The SNP Consortium website: past, present and future", Nucleic Acids Res., 31, pp.124~127 (2003)
  2. International HapMap Consortium, "The International HapMap Project", Nature, 426, pp.789~796 (2003)
  3. Kato, N., "Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians", NATURE GENETICS, 43(6), pp.530~57 (2011), NATURE PUBLISHING GROUP
  4. Soranzo, N., "A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium", Nat. Genet., 41, pp.1182~1190 (2009)
  5. Kim, Y. J., "Large-scale genome-wide association studies in east Asians identify new genetic loci influencing metabolic traits", NATURE GENETICS, 43(10), pp.990~U102 (2011), NATURE PUBLISHING GROUP
  6. Marchini, J., "A new multipoint method for genome-wide association studies by imputation of genotypes", Nat. Genet., 39, pp.906~913 (2007)
  7. Li, Y., "Genotype imputation", Annu Rev Genomics Hum. Genet, 10, pp.387~406 (2009)
  8. Koike, A., "Genome-wide association database developed in theJapanese Integrated Database Project", J. Hum. Genet., 54, pp.543~546 (2009)
  9. Stein, L. D., "The generic genome browser: a building block for a model organism system database", Genome Res., 12, pp.1599~1610 (2002)
  10. Cho, Y. S., "A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits", Nature Genet., 41(5), pp.527~534 (2009)
  11. Purcell, S., "PLINK: a tool set for whole-genome association and population-based linkage analyses", Am. J. Hum. Genet., 81, pp.559~575 (2007)

관련 논문AI추천

EvoSNP-DB: A database of genetic diversity in East Asian populations김영욱, 김영진, 박기정, 이종영생화학분자생물학회 · BMB Reports2013 · 제46권 제8호BioSMACK: a linux live CD for genome-wide association analyses신영아, 이종영, 조윤신, Chang Bum Hong, Dong-Joon Kim, Min Jin Go, Sanghoon Moon, Young Jin Kim생화학분자생물학회 · BMB Reports2012 · 제45권 제1호A database of 5305 healthy Korean individuals reveals genetic and clinical implications for an East Asian population박종화, 윤성수, 이병욱, 장인진, 최무림, 최병옥, 최진욱, Baek Daehyun, Chae Jong-Hee, Gee Heon Yung, Jang Insu, Jeon Sungwon, Kim Young-Joon, Koh Youngil, Lee Jean, Lee JeongEun, Lee Jeongha, Lee Sanghyuk, Oh Jaeseong, Park Soojin, Park Woong-Yang, Yang Jin Ok생화학분자생물학회 · Experimental and Molecular Medicine2022 · 제54권 Development of Korean Rare Disease Knowledge Base강희경, 김도균, 김주한, 서희원, 임병찬, 정해일, 채종희대한의료정보학회 · Healthcare Informatics Research2012 · 제18권 제4호Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population박기정, 조상헌, Bok-Ghee Han, Dankyu Yoon, Eun-Jin Kim, Hyo-Jeong Ban, Hyung-Cheol Kim, Joo-Shil Lee, Jung-Won Park, Soo-Jong Hong, Young Jin Kim생화학분자생물학회 · BMB Reports2012 · 제45권 제5호Inference of kinship coefficients from Korean SNP genotyping data권재근, 김상철, 박성진, 양진옥, 이병욱, 이상혁생화학분자생물학회 · BMB Reports2013 · 제46권 제6호

이 간행물의 다른 논문 (9건)