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Role of vascular smooth muscle cell in the inflammation of atherosclerosis

박성하|임소연
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2014.01|BMB Reports|제47권 제1호|pp. 1-7

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참고문헌

키워드

AtherosclerosisMembrane receptorSmooth muscle cellVascular inflammation
주제분류화학

초록

Atherosclerosis is a pathologic process occurring within theartery, in which many cell types, including T cell,macrophages, endothelial cells, and smooth muscle cells,interact, and cause chronic inflammation, in response tovarious inner- or outer-cellular stimuli. Atherosclerosis ischaracterized by a complex interaction of inflammation, lipiddeposition, vascular smooth muscle cell proliferation,endothelial dysfunction, and extracellular matrix remodeling,which will result in the formation of an intimal plaque. Although the regulation and function of vascular smoothmuscle cells are important in the progression of atherosclerosis,the roles of smooth muscle cells in regulating vascularinflammation are rarely focused upon, compared to those ofendothelial cells or inflammatory cells. Therefore, in thisreview, we will discuss here how smooth muscle cellscontribute or regulate the inflammatory reaction in theprogression of atherosclerosis, especially in the context of theactivation of various membrane receptors, and how they mayregulate vascular inflammation.

Abstract

Atherosclerosis is a pathologic process occurring within theartery, in which many cell types, including T cell,macrophages, endothelial cells, and smooth muscle cells,interact, and cause chronic inflammation, in response tovarious inner- or outer-cellular stimuli. Atherosclerosis ischaracterized by a complex interaction of inflammation, lipiddeposition, vascular smooth muscle cell proliferation,endothelial dysfunction, and extracellular matrix remodeling,which will result in the formation of an intimal plaque. Although the regulation and function of vascular smoothmuscle cells are important in the progression of atherosclerosis,the roles of smooth muscle cells in regulating vascularinflammation are rarely focused upon, compared to those ofendothelial cells or inflammatory cells. Therefore, in thisreview, we will discuss here how smooth muscle cellscontribute or regulate the inflammatory reaction in theprogression of atherosclerosis, especially in the context of theactivation of various membrane receptors, and how they mayregulate vascular inflammation.

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