Nonsense-mediated mRNA decay at the crossroads of many cellular pathways
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other cell processes which regulate or activate it under specific cell conditions or in response to mutations, mis-regulations, stresses, or particular cell programs. These cell processes and their connections with NMD are the focus of this review, which aims both to illustrate the complexity of the NMD mechanism and its regulation and to highlight the cellular consequences of NMD inhibition.
Abstract
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other cell processes which regulate or activate it under specific cell conditions or in response to mutations, mis-regulations, stresses, or particular cell programs. These cell processes and their connections with NMD are the focus of this review, which aims both to illustrate the complexity of the NMD mechanism and its regulation and to highlight the cellular consequences of NMD inhibition.
참고문헌 (146)
- Karousis ED, "Nonsense- mediated mRNA decay: novel mechanistic insights and biological impact", Wiley Interdiscip Rev RNA, 7, pp.661~682 (2016)
- Hug N, "Mechanism and regulation of the nonsense-mediated decay pathway", Nucleic Acids Res, 44, pp.1483~1495 (2016)
- He F, "Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story", Annu Rev Genet, 49, pp.339~366 (2015)
- Maximilian Wei-Lin Popp, "The Dharma of Nonsense-Mediated mRNA Decay in Mammalian Cells", Molecules and Cells, 37(1), pp.1~8 (2014), 한국분자세포생물학회
- Fatscher T, "Mechanism, factors, and physiological role of nonsense-mediated mRNA decay", Cell Mol Life Sci, 72, pp.4523~4544 (2015)
- Lejeune F, "Nonsense mutation correction in human diseases: an approach for targeted medicine", pp.1~192 (2016), Elsevier ed Publisher: Catherine Van Der Laan
- 황정욱, "When a ribosome encounters a premature termination codon", BMB Reports, 46(1), pp.9~16 (2013), 생화학분자생물학회
- Kurosaki T, "Nonsense-mediated mRNA decay in humans at a glance", J Cell Sci, 129, pp.461~467 (2016)
- Behm-Ansmant I, "A conserved role for cytoplasmic poly(A)-binding protein 1(PABPC1)in nonsense-mediated mRNA decay", EMBO J, 26, pp.1591~1601 (2007)
- Eberle AB, "Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region", PLoS Biol, 6, pp.e92~ (2008)
- Ivanov PV, "Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways", EMBO J, 27, pp.736~747 (2008)
- Silva AL, "Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay", RNA, 14, pp.563~576 (2008)
- Metze S, "Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways", RNA, 19, pp.1432~1448 (2013)
- Conti E, "Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species", Curr Opin Cell Biol, 17, pp.316~325 (2005)
- Fiorini F, "Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities", Nat Commun, 6, pp.7581~ (2015)
- Kashima I, "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex(SURF)to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay", Genes Dev, 20, pp.355~367 (2006)
- Melero R, "Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD", Structure, 22, pp.1105~1119 (2014)
- Ohnishi T, "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7", Mol Cell, 12, pp.1187~1200 (2003)
- Okada-Katsuhata Y, "N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD", Nucleic Acids Res, 40, pp.1251~1266 (2012)
- Chang YF, "The nonsense-mediated decay RNA surveillance pathway", Annu Rev Biochem, 76, pp.51~74 (2007)
- Sun X, "mRNA surveillance in mammalian cells: the relationship between introns and translation termination", RNA, 6, pp.1~8 (2000)
- Sun X, "Nonsensemediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position", EMBO J, 19, pp.4734~4744 (2000)
- Zhang J, "Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm", RNA, 4, pp.801~815 (1998)
- Le Hir H, "The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions", EMBO J, 19, pp.6860~6869 (2000)
- L Le Hir H, "Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions", Genes Dev, 14, pp.1098~1108 (2000)
- Ishigaki Y, "Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20", Cell, 106, pp.607~617 (2001)
- Gregersen LH, "MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs", Mol Cell, 54, pp.573~585 (2014)
- Cho H, "Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex", Mol Cell, 33, pp.75~86 (2009)
- Lejeune F, "Nonsensemediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities", Mol Cell, 12, pp.675~687 (2003)
- Huntzinger E, "SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan", RNA, 14, pp.2609~2617 (2008)
- Mascarenhas R, "SMG6 cleavage generates metastable decay intermediates from nonsense-containing beta-globin mRNA", PLoS One, 8, pp.e74791~ (2013)
- Schmidt SA, "Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells", Nucleic Acids Res, 43, pp.309~323 (2015)
- Chiu SY, "The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex", Genes Dev, 18, pp.745~754 (2004)
- Lejeune F, "eIF4G is required for the pioneer round of translation in mammalian cells", Nat Struct Mol Biol, 11, pp.992~1000 (2004)
- Belgrader P, "Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping", Mol Cell Biol, 14, pp.6326~6336 (1994)
- Saulière J, "CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex", Nat Struct Mol Biol, 19, pp.1124~1131 (2012)
- Singh G, "The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus", Cell, 151, pp.750~764 (2012)
- Wang J, "Boundary-independent polar nonsense-mediated decay", EMBO Rep, 3, pp.274~279 (2002)
- Bühler M, "EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length", Nat Struct Mol Biol, 13, pp.462~464 (2006)
- Knezevic V, "The organizer-associated chick homeobox gene, Gnot1, is expressed before gastrulation and regulated synergistically by activin and retinoic acid", Dev Biol, 171, pp.458~470 (1995)
- Nagy E, "A rule for terminationcodon position within intron-containing genes: when nonsense affects RNA abundance", Trends Biochem Sci, 23, pp.198~199 (1998)
- Kebaara BW, "Long 3'-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae", Nucleic Acids Res, 37, pp.2771~2778 (2009)
- Graber JH, "Genomic detection of new yeast pre-mRNA 3'-endprocessing signals", Nucleic Acids Res, 27, pp.888~894 (1999)
- Mignone F, "Untranslated regions of mRNAs", Genome Biol, 3, pp.REVIEWS000~ (2002)
- Singh G, "A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay", PLoS Biol, 6, pp.e111~ (2008)
- Toma KG, "Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay", RNA, 21, pp.887~897 (2015)
- Durand S, "Nonsensemediated mRNA decay occurs during eIF4F-dependent translation in human cells", Nat Struct Mol Biol, 20, pp.702~709 (2013)
- Rufener SC, "eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells", Nat Struct Mol Biol, 20, pp.710~717 (2013)
- Hogg JR, "Upf1 senses 3'UTR length to potentiate mRNA decay", Cell, 143, pp.379~389 (2010)
- Kurosaki T, "A posttranslational regulatory switch on UPF1 controls targeted mRNA degradation", Genes Dev, 28, pp.1900~1916 (2014)
- Kurosaki T, "Rules that govern UPF1 binding to mRNA 3' UTRs", Proc Natl Acad Sci U S A, 110, pp.3357~3362 (2013)
- Zünd D, "Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs", Nat Struct Mol Biol, 20, pp.936~943 (2013)
- Thein SL, "The molecular basis of beta-thalassemia in Thailand: application to prenatal diagnosis", Am J Hum Genet, 47, pp.369~375 (1990)
- Fang Y, "Nonsense-mediated mRNA decay of collagen-emerging complexity in RNA surveillance mechanisms", J Cell Sci, 126, pp.2551~2560 (2013)
- Tan JT, "Competency for nonsense-mediated reduction in collagen X mRNA is specified by the 3' UTR and corresponds to the position of mutations in Schmid metaphyseal chondrodysplasia", Am J Hum Genet, 82, pp.786~793 (2008)
- Cheng J, "Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance", Mol Cell Biol, 14, pp.6317~6325 (1994)
- Zhang J, "At least one intron is required for the nonsensemediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation", Mol Cell Biol, 18, pp.5272~5283 (1998)
- Lejeune F, "Mechanistic links between nonsense-mediated mRNA decay and premRNA splicing in mammalian cells", Curr Opin Cell Biol, 17, pp.309~315 (2005)
- Li C, "Nuclear Pnn", DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1, 2003, pp.23, 7363~7376
- Murachelli AG, "The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex", Nat Struct Mol Biol, 19, pp.378~386 (2012)
- Tange TØ, "Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core", RNA, 11, pp.1869~1883 (2005)
- Luo ML, "Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly", Nature, 413, pp.644~647 (2001)
- Le Hir H, "The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay", EMBO J, 20, pp.4987~4997 (2001)
- Degot S, "Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module", J Biol Chem, 279, pp.33702~33715 (2004)
- Andersen CB, "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA", Science, 313, pp.1968~1972 (2006)
- Bono F, "Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex", EMBO Rep, 5, pp.304~310 (2004)
- Jackson RJ, "The mechanism of eukaryotic translation initiation and principles of its regulation", Nat Rev Mol Cell Biol, 11, pp.113~127 (2010)
- Gatfield D, "REF1", Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export, 2002, pp.159, 579~588
- Gatfield D, "The DExH", D box protein HEL, Curr Biol, pp.2001, 11[DOI]
- Strässer K, "Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export", EMBO J, 19, pp.410~420 (2000)
- Lejeune F, "The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling", EMBO J, 21, pp.3536~3545 (2002)
- Green RE, "Widespread predicted nonsense-mediated mRNA decay of alternatively- spliced transcripts of human normal and disease genes", Bioinformatics, 19(Suppl 1), pp.i118~i121 (2003)
- Lewis BP, "Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans", Proc Natl Acad Sci U S A, 100, pp.189~192 (2003)
- Pan Q, "Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing", Nat Genet, 40, pp.1413~1415 (2008)
- Bourgeois CF, "Broad specificity of SR (serine", arginine) proteins in the regulation of alternative splicing of pre-messenger RNA, 2004, pp.78, 37~88
- Lareau LF, "The coupling of alternative splicing and nonsense-mediated mRNA decay", Adv Exp Med Biol, 623, pp.190~211 (2007)
- Lareau LF, "Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements", Nature, 446, pp.926~929 (2007)
- Bruno IG, "Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay", Mol Cell, 42, pp.500~510 (2011)
- Choe J, "Ago2", miRISC-mediated inhibition of CBP80, FEBS Lett, pp.2011, 585[DOI]
- Choe J, "microRNA", Argonaute 2 regulates nonsense-mediated messenger RNA decay, 2010, pp.11, 380~386
- Hosoda N, "CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells", Nat Struct Mol Biol, 12, pp.893~901 (2005)
- Epstein JA, "Pax3 inhibits myogenic differentiation of cultured myoblast cells", J Biol Chem, 270, pp.11719~11722 (1995)
- Gong C, "SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs", Genes Dev, 23, pp.54~66 (2009)
- Choe J, "The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA", Nucleic Acids Res, 42, pp.9334~9349 (2014)
- Azzalin CM, "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability", Curr Biol, 16, pp.433~439 (2006)
- Belgrader P, "Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA", Proc Natl Acad Sci U S A, 90, pp.482~486 (1993)
- Maquat LE, "Translational Control of Gene Expression" (2000), Cold Spring Harbor Laboratory Press
- Shoemaker CJ, "Translation drives mRNA quality control", Nat Struct Mol Biol, 19, pp.594~601 (2012)
- Apcher S, "Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation", Proc Natl Acad Sci U S A, 108, pp.11572~11577 (2011)
- Kuroha K, "Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome", EMBO Rep, 10, pp.1265~1271 (2009)
- Mazroui R, "Inhibition of the ubiquitin-proteasome system induces stress granule formation", Mol Biol Cell, 18, pp.2603~2618 (2007)
- Mocquet V, "The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6", EIF3E and UPF1, 2012, pp.86, 7530~7543
- Morris C, "Human INT6", eIF3e is required for nonsense-mediated mRNA decay, 2007, pp.8, 596~602
- Martin L, "Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine", glutamate exchanger SLC7A11, 2015, pp.34, 4211~4218
- Wang D, "Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis", Mol Cell Biol, 31, pp.3670~3680 (2011)
- Isken O, "Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay", Cell, 133, pp.314~327 (2008)
- Kunz JB, "Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation", RNA, 12, pp.1015~1022 (2006)
- Nott A, "Splicing enhances translation in mammalian cells: an additional function of the exon junction complex", Genes Dev, 18, pp.210~222 (2004)
- Keeling KM, "Nonsense-mediated mRNA Decay - Landes Bioscience", pp.121~136 (2006)
- Loughran G, "Evidence of efficient stop codon readthrough in four mammalian genes", Nucleic Acids Res, 42, pp.8928~8938 (2014)
- Welch EM, "PTC124 targets genetic disorders caused by nonsense mutations", Nature, 447, pp.87~91 (2007)
- Du L, "Nonaminoglycoside compounds induce readthrough of nonsense mutations", J Exp Med, 206, pp.2285~2297 (2009)
- Salas-Marco J, "Discrimination between defects in elongation fidelity and termination efficiency provides mechanistic insights into translational readthrough", J Mol Biol, 348, pp.801~805 (2005)
- Wang W, "The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts", EMBO J, 20, pp.880~890 (2001)
- Harger JW, "Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough", RNA, 10, pp.1721~1729 (2004)
- Jia J, "PTC-readthrough occurs in specific cytoplasmic foci and requires UPF proteins in human cells", ~
- Keeling K.M, "Therapeutics based on stop codon readthrough", Annu Rev Genomics Hum Genet, 15, pp.371~394 (2014)
- Gonzalez-Hilarion S, "Rescue of nonsense mutations by amlexanox in human cells", Orphanet J Rare Dis, 7, pp.58~ (2012)
- Linde L, "Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin", J Clin Invest, 117, pp.683~692 (2007)
- Keeling KM, "Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression", PLoS One, 8, pp.e60478~ (2013)
- Trcek T, "Temporal and spatial characterization of nonsensemediated mRNA decay", Genes Dev, 27, pp.541~551 (2013)
- Durand S, "Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies", J Cell Biol, 178, pp.1145~1160 (2007)
- Sheth U, "Targeting of aberrant mRNAs to cytoplasmic processing bodies", Cell, 125, pp.1095~1109 (2006)
- Anderson P, "RNA granules: post-transcriptional and epigenetic modulators of gene expression", Nat Rev Mol Cell Biol, 10, pp.430~436 (2009)
- Zheng D, "Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation", RNA, 17, pp.1619~1634 (2011)
- Jia J, "Caspases shutdown nonsense-mediated mRNA decay during apoptosis", Cell Death Differ, 22, pp.1754~1763 (2015)
- Popp MW, "Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics", Nat Commun, 6, pp.6632~ (2015)
- Mendell JT, "Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise", Nat Genet, 36, pp.1073~1078 (2004)
- Reggiori F, "Autophagy in the eukaryotic cell", Eukaryot Cell, 1, pp.11~21 (2002)
- Wengrod J, "Inhibition of nonsense-mediated RNA decay activates autophagy", Mol Cell Biol, 33, pp.2128~2135 (2013)
- Li Z, "Inhibition of nonsense-mediated RNA decay by ER stress", RNA, 23, pp.378~394 (2017)
- Karam R, "Wilkinson MF The unfolded protein response is shaped by the NMD pathway", EMBO Rep, 16, pp.599~609 (2015)
- Oren YS, "The unfolded protein response affects readthrough of premature termination codons", EMBO Mol Med, 6, pp.685~701 (2014)
- Sieber J, "Proteomic Analysis Reveals Branch-specific Regulation of the Unfolded Protein Response by Nonsense-mediated mRNA Decay", Mol Cell Proteomics, 15, pp.1584~1597 (2016)
- Groenendyk J, "Endoplasmic reticulum quality control and apoptosis", Acta Biochim Pol, 52, pp.381~395 (2005)
- Nickless A, "Intracellular calcium regulates nonsense-mediated mRNA decay", Nat Med, 20, pp.961~966 (2014)
- McIlwain DR, "Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay", Proc Natl Acad Sci U S A, 107, pp.12186~12191 (2010)
- Medghalchi SM, "Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability", Hum Mol Genet, 10, pp.99~105 (2001)
- Thoren LA, "UPF2 is a critical regulator of liver development, function and regeneration", PLoS One, 5, pp.e11650~ (2010)
- Jolly LA, "The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth", Hum Mol Genet, 22, pp.4673~4687 (2013)
- Nguyen LS, "Transcriptome profiling of UPF3B", NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability, 2012, pp.17, 1103~1115
- Tzschach A, "Next-generation sequencing in X-linked intellectual disability", Eur J Hum Genet, 23, pp.1513~1518 (2015)
- Addington AM, "A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders", Mol Psychiatry, 16, pp.238~239 (2011)
- Laumonnier F, "Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism", Mol Psychiatry, 15, pp.767~776 (2010)
- Tarpey PS, "Mutations in UPF3B, a member of the nonsense mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation", Nat Genet, 39, pp.1127~1133 (2007)
- Nguyen LS, "Contribution of copy number variants involving nonsensemediated mRNA decay pathway genes to neurodevelopmental disorders", Hum Mol Genet, 22, pp.1816~1825 (2013)
- Weischenfeldt J, "NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements", Genes Dev, 22, pp.1381~1396 (2008)
- Tinguely A, "Cross talk between immunoglobulin heavy-chain transcription and RNA surveillance during B cell development", Mol Cell Biol, 32, pp.107~117 (2012)
- Frischmeyer-Guerrerio PA, "Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice", Proc Natl Acad Sci U S A, 108, pp.10638~10643 (2011)
- Balistreri G, "The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication", Cell Host Microbe, 16, pp.403~411 (2014)
- Ajamian L, "HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA", Biomolecules, 5, pp.2808~2839 (2015)
- Serquiña AK, "UPF1 is crucial for the infectivity of human immunodeficiency virus type 1 progeny virions", J Virol, 87, pp.8853~8861 (2013)
- Viegas MH, "The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway", Nucleic Acids Res, 35, pp.4542~4551 (2007)
- Singh G, "Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm", Mol Cell, 27, pp.780~792 (2007)
- Kim VN, "Role of the nonsense-mediated decay factor hUpf3 in the splicingdependent exon-exon junction complex", Science, 293, pp.1832~1836 (2001)
- Kuzmiak HA, "Applying nonsensemediated mRNA decay research to the clinic: progress and challenges", Trends Mol Med, 12, pp.306~316 (2006)
