Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway
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Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs. In this study, we investigated the effect of HAMSCs on HASCs by a transwell co-culture system. HAMSCs promoted proliferation, osteogenic differentiation, angiogenic potential and adiponectin (APN) secretion of HASCs. Moreover, the positive effect of HAMSCs was significantly inhibited by U0126, a highly selective inhibitor of extracellular signaling-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signaling pathway. These observations suggested that HAMSCs induced bone regeneration in HASCs via ERK1/2 MAPK signaling pathway.
Abstract
Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs. In this study, we investigated the effect of HAMSCs on HASCs by a transwell co-culture system. HAMSCs promoted proliferation, osteogenic differentiation, angiogenic potential and adiponectin (APN) secretion of HASCs. Moreover, the positive effect of HAMSCs was significantly inhibited by U0126, a highly selective inhibitor of extracellular signaling-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signaling pathway. These observations suggested that HAMSCs induced bone regeneration in HASCs via ERK1/2 MAPK signaling pathway.
참고문헌 (37)
- Kassebaum NJ, "Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression", J Dent Res, 93, pp.1045~1053 (2014)[DOI]
- Liu Y, "Human Corneal Endothelial Cells Expanded In Vitro Are a Powerful Resource for Tissue Engineering", Int J Med Sci, 14, pp.128~135 (2017)[DOI]
- Zuk PA, "Human adipose tissue is a source of multipotent stem cells", Mol Biol Cell, 13, pp.4279~4295 (2002)[DOI]
- Hong JM, "Enhancement of bone regeneration through facile surface functionalization of solid freeform fabrication-based three-dimensional scaffolds using mussel adhesive proteins", Acta Biomater, 8, pp.2578~2586 (2012)[DOI]
- Park KH, "Bone morphogenic protein-2 (BMP-2) loaded nanoparticles mixed with human mesenchymal stem cell in fibrin hydrogel for bone tissue engineering", J Biosci Bioeng, 108, pp.530~537 (2009)[DOI]
- Sheridan RL, "Skin substitutes in burns", Burns, 27, pp.92~ (2001)[DOI]
- Alviano F, "Term Amniotic membrane is a high throughput source for multipotent Mesenchymal Stem Cells with the ability to differentiate into endothelial cells in vitro", BMC Dev Biol, 7, pp.11~ (2007)[DOI]
- Wolbank S, "Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue", Tissue Eng, 13, pp.1173~1183 (2007)[DOI]
- Wang Y, "Human amnion mesenchymal stem cells promote proliferation and osteogenic differentiation in human bone marrow mesenchymal stem cells", J Mol Histol, 46, pp.13~20 (2015)[DOI]
- Wang Y, "Human Amnion-Derived Mesenchymal Stem Cells Promote Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells by Influencing the ERK1", 2 Signaling Pathway, 2016, pp.2016, 4851081~
- Ning Chen, "Human Amnion-Derived Mesenchymal Stem Cells Protect Human Bone Marrow Mesenchymal Stem Cells against Oxidative Stress-Mediated Dysfunction via ERK1", 2 MAPK Signaling, 2016, pp.39(3), 186~194[DOI]
- Wang Y, "Role of human amnion-derived mesenchymal stem cells in promoting osteogenic differentiation by influencing p38 MAPK signaling in lipopolysaccharide-induced human bone marrow mesenchymal stem cells", Exp Cell Res, 350, pp.41~49 (2017)[DOI]
- Lee HW, "Adiponectin stimulates osteoblast differentiation through induction of COX2 in mesenchymal progenitor cells", Stem Cells, 27, pp.2254~2262 (2009)[DOI]
- Jiang X, "Effect of intermittent administration of adiponectin on bone regeneration following mandibular osteodistraction in rabbits", J Orthop Res, 29, pp.1081~1085 (2011)[DOI]
- Park M, "APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction", Am J Physiol Endocrinol Metab, 305, pp.795~804 (2013)[DOI]
- Corbella S, "Histomorphometric Results After Postextraction Socket Healing with Different Biomaterials: A Systematic Review of the Literature and Meta-Analysis", Int J Oral Maxillofac Implants, 32, pp.1001~1017 (2017)[DOI]
- Gimble JM, "Adiposederived stem cells for regenerative medicine", Circ Res, 100, pp.1249~1260 (2007)[DOI]
- Tsuji W, "Adipose-derived stem cells: Implications in tissue regeneration", World J Stem Cells, 6, pp.312~321 (2014)[DOI]
- Ruetze M, "Adipose-derived stromal cells for osteoarticular repair: trophic function versus stem cell activity", Expert Rev Mol Med, 16, pp.e9~ (2014)[DOI]
- Kempen DH, "Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration", Biomaterials, 30, pp.2816~2825 (2009)[DOI]
- Kanczler JM, "Osteogenesis and angiogenesis: the potential for engineering bone", Eur Cell Mater, 15, pp.100~114 (2008)[DOI]
- Carano RA, "Angiogenesis and bone repair", Drug Discov Today, 8, pp.980~989 (2003)[DOI]
- Hsiao ST, "Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue", Stem Cells Dev, 21, pp.2189~2203 (2012)[DOI]
- Konig J, "Amnionderived mesenchymal stromal cells show angiogenic properties but resist differentiation into mature endothelial cells", Stem Cells Dev, 21, pp.1309~1320 (2012)[DOI]
- Fierro FA, "Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells", Front Cell Dev Biol, 3, pp.68~ (2015)
- Oshima K, "Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast", Biochem Biophys Res Commun, 331, pp.520~526 (2005)[DOI]
- Williams GA, "In vitro and in vivo effects of adiponectin on bone", Endocrinology, 150, pp.3603~3610 (2009)[DOI]
- Yamaguchi N, "Adiponectin inhibits induction of TNF-alpha", RANKL-stimulated NFATc1 via the AMPK signaling, 2008, pp.582, 451~456
- Chen T, "Adiponectin enhances osteogenic differentiation in human adipose-derived stem cells by activating the APPL1-AMPK signaling pathway", Biochem Biophys Res Commun, 461, pp.237~242 (2015)[DOI]
- Li S, "Slit2 Promotes Angiogenic Activity Via the Robo1-VEGFR2-ERK1", 2 Pathway in Both In Vivo and In Vitro Studies, 2015, pp.56, 5210~5217
- Hammond CL, "Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling", Development, 136, pp.3991~4000 (2009)[DOI]
- Krum SA, "Novel functions for NFkappaB: inhibition of bone formation", Nat Rev Rheumatol, 6, pp.607~611 (2010)[DOI]
- Hu N, "Regulative Effect of Mir-205 on Osteogenic Differentiation of Bone Mesenchymal Stem Cells (BMSCs): Possible Role of SATB2", Runx2 and ERK, Int J Mol Sci, pp.2015, 16[DOI]
- Franceschi RT, "Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways", J Cell Biochem, 88, pp.446~454 (2003)[DOI]
- Zhang D, "Transplanted human amniotic membrane-derived mesenchymal stem cells ameliorate carbon tetrachloride-induced liver cirrhosis in mouse", PLoS One, 6, pp.e16789~ (2011)[DOI]
- Chen YJ, "The effects of acellular amniotic membrane matrix on osteogenic differentiation and ERK1", 2 signaling in human dental apical papilla cells, 2012, pp.33, 455~463
- Kim KI, "Osteogenic differentiation and angiogenesis with cocultured adipose-derived stromal cells and bone marrow stromal cells", Biomaterials, 35, pp.4792~4804 (2014)[DOI]
