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Proteolytic cleavages of MET: the divide-and-conquer strategy of a receptor tyrosine kinase

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Membrane-anchored full-length MET stimulated by its ligand HGF/SF induces various biological responses, including survival, growth, and invasion. This panel of responses, referred to invasive growth, is required for embryogenesis and tissue regeneration in adults. On the contrary, MET deregulation is associated with tumorigenesis in many kinds of cancer. In addition to its well-documented ligand-stimulated downstream signaling, the receptor can be cleaved by proteases such as secretases, caspases, and calpains. These cleavages are involved either in MET receptor inactivation or, more interestingly, in generating active fragments that can modify cell fate. For instance, MET fragments can promote cell death or invasion. Given a large number of proteases capable of cleaving MET, this receptor appears as a prototype of proteolytic-cleavage-regulated receptor tyrosine kinase. In this review, we describe and discuss the mechanisms and consequences, both physiological and pathological, of MET proteolytic cleavages.

Abstract

Membrane-anchored full-length MET stimulated by its ligand HGF/SF induces various biological responses, including survival, growth, and invasion. This panel of responses, referred to invasive growth, is required for embryogenesis and tissue regeneration in adults. On the contrary, MET deregulation is associated with tumorigenesis in many kinds of cancer. In addition to its well-documented ligand-stimulated downstream signaling, the receptor can be cleaved by proteases such as secretases, caspases, and calpains. These cleavages are involved either in MET receptor inactivation or, more interestingly, in generating active fragments that can modify cell fate. For instance, MET fragments can promote cell death or invasion. Given a large number of proteases capable of cleaving MET, this receptor appears as a prototype of proteolytic-cleavage-regulated receptor tyrosine kinase. In this review, we describe and discuss the mechanisms and consequences, both physiological and pathological, of MET proteolytic cleavages.

참고문헌 (90)

  1. Birchmeier C, "Met, metastasis, motility and more", Nat Rev Mol Cell Biol, 4, pp.915~925 (2003)
  2. Bladt F, "Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud", Nature, 376, pp.768~771 (1995)
  3. Schmidt C, "Scatter factor", hepatocyte growth factor is essential for liver development, 1995, pp.373, 699~702
  4. Uehara Y, "Placental defect and embryonic lethality in mice lacking hepatocyte growth factor", scatter factor, 1995, pp.373, 702~705
  5. Maina F, "Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons", Genes Dev, 11, pp.3341~3350 (1997)
  6. Chmielowiec J, "c-Met is essential for wound healing in the skin", J Cell Biol, 177, pp.151~162 (2007)
  7. Borowiak M, "Met provides essential signals for liver regeneration", Proc Natl Acad Sci U S A, 101, pp.10608~10613 (2004)
  8. Huh CG, "Hepatocyte growth factor", c-met signaling pathway is required for efficient liver regeneration and repair, 2004, pp.101, 4477~4482
  9. Schiering N, "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a", Proc Natl Acad Sci U S A, 100, pp.12654~12659 (2003)
  10. Longati P, "Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET protooncogene(HGF receptor)", Oncogene, 9, pp.49~57 (1994)
  11. Ponzetto C, "A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor", scatter factor receptor family, 1994, pp.77, 261~271
  12. Maina F, "Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development", Cell, 87, pp.531~542 (1996)
  13. Peschard P, "Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein", Mol Cell, 8, pp.995~1004 (2001)
  14. Hashigasako A, "Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor", J Biol Chem, 279, pp.26445~26452 (2004)
  15. Duplaquet L, "The multiple paths towards MET receptor addiction in cancer", Oncogene, 37, pp.3200~3215 (2018)
  16. Olivero M, "Overexpression and activation of hepatocyte growth factor", scatter factor in human non-small-cell lung carcinomas, 1996, pp.74, 1862~1868
  17. Ichimura E, "Expression of c-met", HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance, 1996, pp.87, 1063~1069
  18. Wislez M, "Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma : role in tumor progression and death", Cancer Res, 63, pp.1405~1412 (2003)
  19. Park S, "High MET copy number and MET overexpression : poor outcome in non-small cell lung cancer patients", Histol Histopathol, 27, pp.197~207 (2012)
  20. Koochekpour S, "Met and hepatocyte growth factor", scatter factor expression in human gliomas, 1997, pp.57, 5391~5398
  21. Ferracini R, "The Met", HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit, 1995, pp.10, 739~749
  22. Tuck AB, "Coexpression of hepatocyte growth factor and receptor(Met)in human breast carcinoma", Am J Pathol, 148, pp.225~232 (1996)
  23. Ponzetto C, "c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase", Oncogene, 6, pp.553~559 (1991)
  24. Watermann I, "Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?", Diagn Pathol, 10, pp.130~ (2015)
  25. Yang Y, "MET overexpression and amplification define a distinct molecular subgroup for targeted therapies in gastric cancer", Gastric Cancer, 19, pp.778~788 (2016)
  26. Sattler M, "The role of the c-Met pathway in lung cancer and the potential for targeted therapy", Ther Adv Med Oncol, 3, pp.171~184 (2011)
  27. Krishnaswamy S, "Ethnic differences and functional analysis of MET mutations in lung cancer", Clin Cancer Res, 15, pp.5714~5723 (2009)
  28. Baldacci S, "Outcome of EGFR-mutated NSCLC patients with MET-driven resistance to EGFR tyrosine kinase inhibitors", Oncotarget, 8, pp.105103~105114 (2017)
  29. Prat M, "C-terminal truncated forms of Met, the hepatocyte growth factor receptor", Mol Cell Biol, 11, pp.5954~5962 (1991)
  30. Galvani AP, "Suramin modulates cellular levels of hepatocyte growth factor receptor by inducing shedding of a soluble form", Biochem Pharmacol, 50, pp.959~966 (1995)
  31. Jeffers M, "Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway", Mol Cell Biol, 17, pp.799~808 (1997)
  32. Kopitz C, "Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling", Cancer Res, 67, pp.8615~8623 (2007)
  33. Schelter F, "A disintegrin and metalloproteinase-10(ADAM-10)mediates DN30antibody-induced shedding of the met surface receptor", J Biol Chem, 285, pp.26335~26340 (2010)
  34. Wajih N, "Vascular origin of a soluble truncated form of the hepatocyte growth factor receptor(c-met)", Circ Res, 90, pp.46~52 (2002)
  35. Foveau B, "Downregulation of the Met Receptor Tyrosine Kinase by Presenilindependent Regulated Intramembrane Proteolysis", Mol Biol Cell, 20, pp.2494~2506 (2009)
  36. Ancot F, "Shedding-Generated Met Receptor Fragments can be Routed to Either the Proteasomal or the Lysosomal Degradation Pathway", Traffic, 13, pp.1261~1272 (2012)
  37. Miller MA, "ADAM-10 and-17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling", Proc Natl Acad Sci U S A, 110, pp.E2074~2083 (2013)
  38. Trusolino L, "MET signalling : principles and functions in development, organ regeneration and cancer", Nat Rev Mol Cell Biol, 11, pp.834~848 (2010)
  39. Copin MC, "High-MET status in non-small cell lung tumors correlates with receptor phosphorylation but not with the serum level of soluble form", Lung Cancer, 101, pp.59~67 (2016)
  40. McNeil BK, "Preliminary evaluation of urinary soluble Met as a biomarker for urothelial carcinoma of the bladder", J Transl Med, 12, pp.199~ (2014)
  41. Michieli P, "Targeting the tumor and its microenvironment by a dual-function decoy Met receptor", Cancer Cell, 6, pp.61~73 (2004)
  42. Tulasne D, "Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage", Mol Cell Biol, 24, pp.10328~10339 (2004)
  43. Lefebvre J, "Caspasegenerated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity", Cell Death Dis, 4, pp.e871~ (2013)
  44. Mebratu YA, "Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria", Nat Commun, 8, pp.803~ (2017)
  45. Foveau B, "Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor", Cell Death Differ, 14, pp.752~764 (2007)
  46. Ma J, "A novel death defying domain in met entraps the active site of caspase-3 and blocks apoptosis in hepatocytes", Hepatology, 59, pp.2010~2021 (2013)
  47. Furlan A, "How does met regulate the survival", apoptosis balance?, 2013, pp.60, 1108~1109
  48. Peschard P, "A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl", Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation, 2004, pp.279, 29565~29571
  49. Deheuninck J, "Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage", Cell Signal, 21, pp.1455~1463 (2009)
  50. Deheuninck J, "Caspase cleavage of the MET receptor generates an HGF interfering fragment", Biochem Biophys Res Commun, 367, pp.573~577 (2008)
  51. Bredesen DE, "Receptors that mediate cellular dependence", Cell Death Differ, 12, pp.1031~1043 (2005)
  52. Negulescu AM, "Dependence receptors-the dark side awakens", FEBS J, 285, pp.3909~3924 (2018)
  53. Ichim G, "The Dependence Receptor TrkC Triggers Mitochondria-Dependent Apoptosis upon Cobra-1 Recruitment", Mol Cell, 51, pp.632~646 (2013)
  54. Menard M, "Hey1-and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth", PLoS Biol, 16, pp.e2002912~ (2018)
  55. Halestrap AP, "A pore way to die : the role of mitochondria in reperfusion injury and cardioprotection", Biochem Soc Trans, 38, pp.841~860 (2010)
  56. Francis RJ, "Ca2+activation of cytosolic calpain induces the transition from apoptosis to necrosis in neutrophils with externalized phosphatidylserine", J Leukoc Biol, 93, pp.95~100 (2013)
  57. Yun B, "Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation", J Biol Chem, 289, pp.1491~1504 (2014)
  58. Montagne R, "Necrosisand apoptosis-related Met cleavages have divergent functional consequences", Cell Death Dis, 6, pp.e1769~ (2015)
  59. Billger M, "Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules", Cell Calcium, 9, pp.33~44 (1988)
  60. Czogalla A, "Spectrin and calpain : a 'target' and a 'sniper' in the pathology of neuronal cells", Cell Mol Life Sci, 62, pp.1913~1924 (2005)
  61. Kelly BL, "Beta-amyloidinduced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease", J Biol Chem, 280, pp.31746~31753 (2005)
  62. Cortot AB, "Exon 14 deleted MET receptor as a new biomarker and target in cancers", J Natl Cancer Inst, 109 (2017)
  63. Lee JH, "A novel germ line juxtamembrane Met mutation in human gastric cancer", Oncogene, 19, pp.4947~4953 (2009)
  64. Ma PC, "c-MET mutational analysis in small cell lung cancer : novel juxtamembrane domain mutations regulating cytoskeletal functions", Cancer Res, 63, pp.6272~6281 (2003)
  65. Tyner JW, "MET receptor sequence variants R970C and T992I lack transforming capacity", Cancer Res, 70, pp.6233~6237 (2010)
  66. Shieh JM, "Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis", Int J Med Sci, 10, pp.988~994 (2013)
  67. Boland JM, "MET and EGFR mutations identified in ALK-rearranged pulmonary adenocarcinoma : molecular analysis of 25 ALK-positive cases", J Thorac Oncol, 8, pp.574~581 (2013)
  68. Zaffaroni D, "Met proto-oncogene juxtamembrane rare variations in mouse and humans : differential effects of Arg and Cys alleles on mouse lung tumorigenesis", Oncogene, 24, pp.1084~1090 (2005)
  69. Montagne R, "MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering", Oncotarget, 8, pp.11268~11283 (2017)
  70. Merilahti JAM, "Gamma-secretasedependent signaling of receptor tyrosine kinases", Oncogene, 38, pp.151~163 (2019)
  71. Matteucci E, "Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells", Carcinogenesis, 30, pp.937~945 (2009)
  72. CHAUDHARYSHUBHASHCHANDRA, "A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met", Experimental and Molecular Medicine, 46, pp.1~13 (2014), 생화학분자생물학회
  73. Tauszig-Delamasure S, "The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm", Proc Natl Acad Sci U S A, 104, pp.13361~13366 (2007)
  74. Bordeaux MC, "The RET proto-oncogene induces apoptosis : a novel mechanism for Hirschsprung disease", EMBO J, 19, pp.4056~4063 (2000)
  75. Wang H, "The Proto-oncogene c-Kit Inhibits Tumor Growth by Behaving as a Dependence Receptor", Mol Cell, 72, pp.413~425 (2018)[DOI]
  76. Genevois AL, "Dependence receptor TrkC is a putative colon cancer tumor suppressor", Proc Natl Acad Sci U S A, 110, pp.3017~3022 (2013)
  77. Luo Y, "NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer", PLoS Genet, 9, pp.e1003552~ (2013)
  78. De Oliveira AT, "MET Is highly expressed in advanced stages of colorectal cancer and indicates worse prognosis and mortality", Anticancer Res, 29, pp.4807~4811 (2009)
  79. Petrelli A, "Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity", Proc Natl Acad Sci U S A, 103, pp.5090~5095 (2006)
  80. Pacchiana G, "Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody", J Biol Chem, 285, pp.36149~36157 (2010)
  81. Cignetto S, "Dual Constant Domain-Fab : A novel strategy to improve half-life and potency of a Met therapeutic antibody", Mol Oncol, 10, pp.938~948 (2016)
  82. Vigna E, "Inhibition of ligand-independent constitutive activation of the Met oncogenic receptor by the engineered chemically-modified antibody DN30", Mol Oncol, 9, pp.1760~1772 (2015)
  83. Vigna E, "Targeted therapy by gene transfer of a monovalent antibody fragment against the Met oncogenic receptor", J Mol Med (Berl), 92, pp.65~76 (2014)
  84. Basilico C, "Targeting the MET oncogene by concomitant inhibition of receptor and ligand via an antibody-"decoy"strategy", Int J Cancer (2018)
  85. Perk LR, "Quantitative PET imaging of Met-expressing human cancer xenografts with 89Zr-labelled monoclonal antibody DN30", Eur J Nucl Med Mol Imaging, 35, pp.1857~1867 (2008)
  86. Athauda G, "c-Met ectodomain shedding rate correlates with malignant potential", Clin Cancer Res, 12(14 Pt 1), pp.4154~4162 (2006)
  87. Fu L, "Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer", Biomarkers, 18, pp.126~135 (2013)
  88. Lv H, "Soluble c-Met is a reliable and sensitive marker to detect c-Met expression level in lung cancer", Biomed Res Int, 2015, pp.626578~ (2015)
  89. Engelman JA, "MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling", Science, 316, pp.1039~1043 (2007)
  90. Siebel C, "Notch Signaling in Development, Tissue Homeostasis, and Disease", Physiol Rev, 97, pp.1235~1294 (2017)

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