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Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy

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초록

Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes that function as signaling molecules for regulating a diverse range of cellular processes, including cell proliferation, growth, survival, immune-cell trafficking, vascular and epithelial integrity, and inflammation. Recently, several studies have highlighted the pivotal role of sphingolipids in neuroinflammatory regulation. Sphingolipids have multiple functions, including induction of the expression of various inflammatory mediators and regulation of neuroinflammation by directly effecting the cells of the central nervous system. Accumulating evidence points to sphingolipid engagement in neuroinflammatory disorders, including Alzheimer’s and Parkinson’s diseases. Abnormal sphingolipid alterations, which involves an increase in ceramide and a decrease in sphingosine kinase, are observed during neuroinflammatory disease. These trends are observed early during disease development, and thus highlight the potential of sphingolipids as a new therapeutic and diagnostic target for neuroinflammatory diseases.

Abstract

Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes that function as signaling molecules for regulating a diverse range of cellular processes, including cell proliferation, growth, survival, immune-cell trafficking, vascular and epithelial integrity, and inflammation. Recently, several studies have highlighted the pivotal role of sphingolipids in neuroinflammatory regulation. Sphingolipids have multiple functions, including induction of the expression of various inflammatory mediators and regulation of neuroinflammation by directly effecting the cells of the central nervous system. Accumulating evidence points to sphingolipid engagement in neuroinflammatory disorders, including Alzheimer’s and Parkinson’s diseases. Abnormal sphingolipid alterations, which involves an increase in ceramide and a decrease in sphingosine kinase, are observed during neuroinflammatory disease. These trends are observed early during disease development, and thus highlight the potential of sphingolipids as a new therapeutic and diagnostic target for neuroinflammatory diseases.

참고문헌 (62)

  1. Maceyka M, "Sphingolipid metabolites in inflammatory disease", Nature, 510, pp.58~67 (2014)
  2. Merrill AH Jr, "Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics", Chem Rev, 111, pp.6387~6422 (2011)
  3. Hannun YA, "Sphingolipids and their metabolism in physiology and disease", Nat Rev Mol Cell Biol, 19, pp.175~191 (2018)
  4. Nixon GF, "Sphingolipids in inflammation : pathological implications and potential therapeutic targets", Br J Pharmacol, 158, pp.982~993 (2009)
  5. Chitnis T, "CNS inflammation and neurodegeneration", J Clin Invest, 127, pp.3577~3587 (2017)
  6. Brambilla R, "Neuroinflammation, the thread connecting neurological disease : Cluster : "Neuroinflammatory mechanisms in neurodegenerative disorders"", Acta Neuropathol, 137, pp.689~691 (2019)
  7. Schwartz M, "The resolution of neuroinflammation in neurodegeneration : leukocyte recruitment via the choroid plexus", EMBO J, 33, pp.7~22 (2014)
  8. Norris GT, "Immune cells and CNS physiology : Microglia and beyond", J Exp Med, 216, pp.60~70 (2019)
  9. Arcuri C, "The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS", Front Mol Neurosci, 10, pp.191~ (2017)
  10. Zhu M, "Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42Phagocytosis", Mol Neurobiol, 53, pp.2733~2749 (2016)
  11. Kosicek M, "Phospholipids and Alzheimer's disease : alterations, mechanisms and potential biomarkers", Int J Mol Sci, 14, pp.1310~1322 (2013)
  12. Assi E, "Sphingolipids and brain resident macrophages in neuroinflammation : an emerging aspect of nervous system pathology", Clin Dev Immunol, 2013, pp.309302~ (2013)
  13. Liu Q, "Lipid metabolism in Alzheimer's disease", Neurosci Bull, 30, pp.331~345 (2014)
  14. Yin F, "Energy metabolism and inflammation in brain aging and Alzheimer's disease", Free Radic Biol Med, 100, pp.108~122 (2016)
  15. Davies L, "Sphingolipids in neuroinflammation", Handb Exp Pharmacol, 216, pp.421~430 (2013)
  16. Mesa-Herrera F, "Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases : A Window for the Development of New Biomarkers", Int J Mol Sci, 20, pp.E3810~ (2019)
  17. Di Pardo A, "Sphingolipid Metabolism : A New Therapeutic Opportunity for Brain Degenerative Disorders", Front Neurosci, 12, pp.249~ (2018)
  18. Szepesi Z, "Bidirectional Microglia-Neuron Communication in Health and Disease", Front Cell Neurosci, 12, pp.323~ (2018)
  19. Young MM, "Sphingolipids : regulators of crosstalk between apoptosis and autophagy", J Lipid Res, 54, pp.5~19 (2013)
  20. Czubowicz K, "The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders", Mol Neurobiol, 56, pp.5436~5455 (2019)
  21. Jęśko H, "The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling : Significance for Aging and Neurodegeneration", Mol Neurobiol, 56, pp.3501~3521 (2019)
  22. Pahan K, "Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes", J Biol Chem, 273, pp.2591~2600 (1998)
  23. Liu L, "Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1in primary neurons by sphingomyelinases", Neurobiol Aging, 34, pp.540~550 (2013)
  24. de Wit NM, "Astrocytic ceramide as possible indicator of neuroinflammation", J Neuroinflammation, 16, pp.48~ (2019)
  25. Jung JS, "Anti-inflammatory mechanism of exogenous C2 ceramide in lipopolysaccharide-stimulated microglia", Biochim Biophys Acta, 1831, pp.1016~1026 (2013)
  26. Fischer I, "Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions", PLoS One, 6, pp.e23905~ (2011)
  27. Grassi S, "Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases", Front Pharmacol, 10, pp.807~ (2019)
  28. Karunakaran I, "Sphingosine 1-phosphate-A double edged sword in the brain", Biochim Biophys Acta Biomembr, 1859, pp.1573~1582 (2017)
  29. Spiegel S, "The outs and the ins of sphingosine-1-phosphate in immunity", Nat Rev Immunol, 11, pp.403~415 (2011)
  30. Wu YP, "Sphingosine kinase 1", S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease, 2008, pp.17, 2257~2264
  31. Rothhammer V, "Control of autoimmune CNS inflammation by astrocytes", Semin Immunopathol, 37, pp.625~638 (2015)
  32. Chalfant CE, "Sphingosine 1-phosphate and ceramide 1-phosphate : expanding roles in cell signaling", J Cell Sci, 118, pp.4605~4612 (2005)
  33. Lee JY, "Neuronal SphK1acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease", Nat Commun, 9, pp.1479~ (2018)
  34. Kalgutkar AS, "Aspirin-like molecules that covalently inactivate cyclooxygenase-2", Science, 280, pp.1268~1270 (1998)
  35. Müller N, "COX-2 Inhibitors, Aspirin, and Other Potential Anti-Inflammatory Treatments for Psychiatric Disorders", Front Psychiatry, 10, pp.375~ (2019)
  36. Serhan CN, "Pro-resolving lipid mediators are leads for resolution physiology", Nature, 510, pp.92~101 (2014)
  37. Buckley CD, "Proresolving lipid mediators and mechanisms in the resolution of acute inflammation", Immunity, 40, pp.315~327 (2014)
  38. Fullerton JN, "Lipid mediators in immune dysfunction after severe inflammation", Trends Immunol, 35, pp.12~21 (2014)
  39. Mencarelli C, "Ceramide function in the brain : when a slight tilt is enough", Cell Mol Life Sci, 70, pp.181~203 (2013)
  40. Graham WV, "Update on Alzheimer's Disease Therapy and Prevention Strategies", Annu Rev Med, 68, pp.413~430 (2017)
  41. Cerquera-Jaramillo MA, "Visual Features in Alzheimer's Disease : From Basic Mechanisms to Clinical Overview", Neural Plast, 2018, pp.2941783~ (2018)
  42. Heppner FL, "Immune attack : the role of inflammation in Alzheimer disease", Nat Rev Neurosci, 16, pp.358~372 (2015)
  43. Visan I, "Alzheimer's disease microglia", Nat Immunol, 18, pp.876~ (2017)
  44. Katsumoto A, "Microglia in Alzheimer's Disease : Risk Factors and Inflammation", Front Neurol, 9, pp.978~ (2018)
  45. Jazvinšćak Jembrek M, "Ceramides in Alzheimer's Disease : Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation", Oxid Med Cell Longev, 2015, pp.346783~ (2015)
  46. Couttas TA, "Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis", Acta Neuropathol Commun, 2, pp.9~ (2014)
  47. Ceccom J, "Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease", Acta Neuropathol Commun, 2, pp.12~ (2014)
  48. Salter MW, "Microglia emerge as central players in brain disease", Nat Med, 23, pp.1018~1027 (2017)
  49. Ulland TK, "TREM2-a key player in microglial biology and Alzheimer disease", Nat Rev Neurol, 14, pp.667~675 (2018)
  50. Fakhoury M, "Microglia and Astrocytes in Alzheimer's Disease : Implications for Therapy", Curr Neuropharmacol, 16, pp.508~518 (2018)
  51. 김승현, "A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation", Dementia and Neurocognitive Disorders(대한치매학회지), 18(2), pp.33~46 (2019), 대한치매학회[DOI]
  52. Alhouayek M, "COX-2-derived endocannabinoid metabolites as novel inflammatory mediators", Trends Pharmacol Sci, 35, pp.284~292 (2014)
  53. Bertolini A, "Selective COX-2 inhibitors and dual acting anti-inflammatory drugs : critical remarks", Curr Med Chem, 9, pp.1033~1043 (2002)
  54. Chiang N, "Aspirin triggers formation of anti-inflammatory mediators : New mechanism for an old drug", Discov Med, 4, pp.470~475 (2004)
  55. Kotilinek LA, "Cyclooxygenase-2 inhibition improves amyloid-betamediated suppression of memory and synaptic plasticity", Brain, 131, pp.651~664 (2008)
  56. Mitchell JA, "COX isoforms in the cardiovascular system : understanding the activities of non-steroidal anti-inflammatory drugs", Nat Rev Drug Discov, 5, pp.75~86 (2006)
  57. Xu XM, "Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate", Proc Natl Acad Sci U S A, 96, pp.5292~5297 (1999)
  58. Cuello AC, "Early and Late CNS Inflammation in Alzheimer's Disease: Two Extremes of a Continuum?", Trends Pharmacol Sci, 38, pp.956~966 (2017)
  59. Poewe W, "Parkinson disease", Nat Rev Dis Primers, 3, pp.17013~ (2017)
  60. Engelender S, "The Threshold Theory for Parkinson's Disease", Trends Neurosci, 40, pp.4~14 (2017)
  61. Charvin D, "Therapeutic strategies for Parkinson disease : beyond dopaminergic drugs", Nat Rev Drug Discov, 17, pp.844~ (2018)
  62. McGregor MM, "Circuit Mechanisms of Parkinson's Disease", Neuron, 101, pp.1042~1056 (2019)

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