Ethanol inhibits Kv7.2/7.3 channel open probability by reducing the PI(4,5)P2 sensitivity of Kv7.2 subunit

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참고문헌 (36)

1. Harrison NL, "Effects of acute alcohol on excitability in the CNS", Neuropharmacology, 122, pp.36~45 (2017)
2. Alderazi Y, "Alcohol and the nervous system", Curr Diagn Pathol, 13, pp.203~209 (2007)
3. Hirota Y, "Effect of ethanol on contraction and relaxation of isolated rat ventricular muscle", J Mol Cell Cardiol, 8, pp.727~732 (1976)
4. Harris RA, "Ethanol’s molecular targets", Sci Signal, 1, pp.re7~ (2008)
5. Kruse SW, "Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster", Nat Struct Mol Biol, 10, pp.694~700 (2003)
6. Bodhinathan K, "Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels", Proc Natl Acad Sci U S A, 110, pp.18309~18314 (2013)
7. Koyama S, "Ethanol inhibition of M-current and ethanol-induced direct excitation of ventral tegmental area dopamine neurons", J Neurophysiol, 97, pp.1977~1985 (2007)
8. Brown DA, "Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone", Nature, 283, pp.673~676 (1980)
9. Greene DL, "Modulation of Kv7 channels and excitability in the brain", Cell Mol Life Sci, 74, pp.495~508 (2017)
10. Wang H-S, "KCNQ2 and KCNQ3potassium channel subunits : molecular correlates of the M-channel", Science, 282, pp.1890~1893 (1998)
11. Telezhkin V, "Distinct subunit contributions to the activation of M-type potassium channels by PI(4, 5)P2", J Gen Physiol, 140, pp.41~53 (2012)
12. Suh BC, "Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4, 5-bisphosphate synthesis", Neuron, 35, pp.507~520 (2002)
13. Falkenburger BH, "Kinetics of PIP2 metabolism and KCNQ2", 3 channel regulation studied with a voltage-sensitive phosphatase in living cells, 2010, pp.135, 99~114
14. Zhang Q, "Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2channel gating", Proc Natl Acad Sci U S A, 110, pp.20093~20098 (2013)
15. Choveau FS, "Phosphatidylinositol 4, 5-bisphosphate(PIP2)regulates KCNQ3 K+ channels by interacting with four cytoplasmic channel domains", J Biol Chem, 293, pp.19411~19428 (2018)
16. Kim KW, "Ethanol elevates excitability of superior cervical ganglion neurons by inhibiting Kv7 channels in a cell type-specific and PI(4, 5)P2-dependent manner", Int J Mol Sci, 20, pp.4419~ (2019)
17. Hadley JK, "Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels", Br J Pharmacol, 129, pp.413~415 (2000)
18. Holmgren M, "Trapping of organic blockers by closing of voltage-dependent K+ channels : Evidence for a trap door mechanism of activation gating", J Gen Physiol, 109, pp.527~535 (1997)
19. Suh BC, "Electrostatic Interaction of internal Mg2+ with membrane PIP2 seen with KCNQ K+ channels", J Gen Physiol, 130, pp.241~256 (2007)
20. Keum D, "Phosphoinositide 5-and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence", Proc Natl Acad Sci U S A, 113, pp.E3686~E3695 (2016)
21. Jensen JB, "Fluorescence changes reveal kinetic steps of muscarinic receptor-mediated modulation of phosphoinositides and Kv7. 2", 7. 3K+ channels, 2009, pp.133, 347~359
22. Kutluay E, "Rapid intracellular TEA block of the KcsA potassium channel", Biophys J, 88, pp.1018~1029 (2005)
23. Luzhkov VB, "Mechanisms of tetraethylammonium ion block in the KcsA potassium channel", FEBS Lett, 495, pp.191~196 (2001)
24. Pegan S, "Andersen’s syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2. 1", Biochemistry, 45, pp.8599~8606 (2006)
25. Aryal P, "A discrete alcohol pocket involved in GIRK channel activation", Nat Neurosci, 12, pp.988~995 (2009)
26. Covarrubias M, "Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia", J Biol Chem, 270, pp.19408~19416 (1995)
27. Villarroel A, "Nonstationary noise analysis of M currents simulated and recorded in PC12 cells", J Neurophysiol, 77, pp.2131~2138 (1997)
28. Tatulian L, "Effect of the KCNQ potassium channel opener retigabine on single KCNQ2", 3channels expressed in CHO cells, 2003, pp.549, 57~63
29. Schwake M, "Surface expression and single channel properties of KCNQ2", KCNQ3, M-type K+ channels involved in epilepsy, 2000, pp.275, 13343~13348
30. Selyanko AA, "Properties of single M-type KCNQ2", KCNQ3 potassium channels expressed in mammalian cells, 2001, pp.534, 15~24
31. Gao H, "Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4, 5-bisphosphate", Proc Natl Acad Sci U S A, 114, pp.E6410~E6419 (2017)
32. Zhang H, "PIP2 activates KCNQ channels, and its hydrolysis underlies receptormediated inhibition of M currents", Neuron, 37, pp.963~975 (2003)
33. Keum D, "Voltage-dependent regulation of CaV2. 2 channels by Gqcoupled receptor is facilitated by membrane-localized βsubunit", J Gen Physiol, 144, pp.297~309 (2014)
34. Alvarez O, "Counting channels : A tutorial guide on ion channel fluctuation analysis", Adv Physio Educ, 26, pp.327~341 (2002)
35. Hartveit E, "Studying properties of neurotransmitter receptors by non-stationary noise analysis of spontaneous postsynaptic currents and agonist-evoked responses in outside-out patches", Nat Protoc, 2, pp.434~448 (2007)
36. Lim NK, "Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A", J Gen Physiol, 148, pp.375~392 (2016)

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