Proprioception, the regulator of motor function
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In animals, proper locomotion is crucial to find mates andfoods and avoid predators or dangers. Multiple sensory systemsdetect external and internal cues and integrate them to modulatemotor outputs. Proprioception is the internal sense of bodyposition, and proprioceptive control of locomotion is essentialto generate and maintain precise patterns of movement orgaits. This proprioceptive feedback system is conserved in manyanimal species and is mediated by stretch-sensitive receptorscalled proprioceptors. Recent studies have identified multipleproprioceptive neurons and proprioceptors and their roles inthe locomotion of various model organisms. In this review wedescribe molecular and neuronal mechanisms underlying proprioceptivefeedback systems in C. elegans, Drosophila, andmice.
Abstract
In animals, proper locomotion is crucial to find mates andfoods and avoid predators or dangers. Multiple sensory systemsdetect external and internal cues and integrate them to modulatemotor outputs. Proprioception is the internal sense of bodyposition, and proprioceptive control of locomotion is essentialto generate and maintain precise patterns of movement orgaits. This proprioceptive feedback system is conserved in manyanimal species and is mediated by stretch-sensitive receptorscalled proprioceptors. Recent studies have identified multipleproprioceptive neurons and proprioceptors and their roles inthe locomotion of various model organisms. In this review wedescribe molecular and neuronal mechanisms underlying proprioceptivefeedback systems in C. elegans, Drosophila, andmice.
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