Emerging roles of PHLPP phosphatases in metabolism
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Over the last decades, research has focused on the role of pleckstrinhomology (PH) domain leucine-rich repeat protein phosphatases(PHLPPs) in regulating cellular signaling via PI3K/Aktinhibition. The PKB/Akt signaling imbalances are associated witha variety of illnesses, including various types of cancer, inflammatoryresponse, insulin resistance, and diabetes, demonstratingthe relevance of PHLPPs in the prevention of diseases. Furthermore,identification of novel substrates of PHLPPs unveils theirrole as a critical mediator in various cellular processes. Recently,researchers have explored the increasing complexity of signalingnetworks involving PHLPPs whereby relevant information ofPHLPPs in metabolic diseases was obtained. In this review, wediscuss the current knowledge of PHLPPs on the well-knownsubstrates and metabolic regulation, especially in liver, pancreaticbeta cell, adipose tissue, and skeletal muscle in relation withthe stated diseases. Understanding the context-dependent functionsof PHLPPs can lead to a promising treatment strategy for severalkinds of metabolic diseases.
Abstract
Over the last decades, research has focused on the role of pleckstrinhomology (PH) domain leucine-rich repeat protein phosphatases(PHLPPs) in regulating cellular signaling via PI3K/Aktinhibition. The PKB/Akt signaling imbalances are associated witha variety of illnesses, including various types of cancer, inflammatoryresponse, insulin resistance, and diabetes, demonstratingthe relevance of PHLPPs in the prevention of diseases. Furthermore,identification of novel substrates of PHLPPs unveils theirrole as a critical mediator in various cellular processes. Recently,researchers have explored the increasing complexity of signalingnetworks involving PHLPPs whereby relevant information ofPHLPPs in metabolic diseases was obtained. In this review, wediscuss the current knowledge of PHLPPs on the well-knownsubstrates and metabolic regulation, especially in liver, pancreaticbeta cell, adipose tissue, and skeletal muscle in relation withthe stated diseases. Understanding the context-dependent functionsof PHLPPs can lead to a promising treatment strategy for severalkinds of metabolic diseases.
참고문헌 (67)
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