The role of EZH1 and EZH2 in development and cancer

키워드

참고문헌 (63)

1. Yu JR, "PRC2 is high maintenance", Genes Dev, 33, pp.903~905 (2019)
2. Margueron R, "The polycomb complex PRC2 and its mark in life", Nature, 469, pp.343~349 (2011)
3. Chen S, "Unique structural platforms of Suz12 dictate distinct classes of PRC2 for chromatin binding", Mol Cell, 69, pp.802~819 (2018)
4. Margueron R, "Role of the polycomb protein EED in the propagation of repressive histone marks", Nature, 461, pp.762~767 (2009)
5. Cao R, "Role of histone H3lysine 27 methylation in polycomb-group silencing", Science, 298, pp.1039~1043 (2002)
6. Czermin B, "Drosophila enhancer of Zeste", ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites, 2002, pp.111, 185~196
7. Kuzmichev A, "Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of zeste protein", Genes Dev, 16, pp.2893~2905 (2002)
8. Justin N, "Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2", Nat Commun, 7, pp.11316~ (2016)
9. Lee CH, "Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin", Mol Cell, 70, pp.422~434 (2018)
10. Hansen KH, "A model for transmission of the H3K27me3 epigenetic mark", Nat Cell Biol, 10, pp.1291~1300 (2008)
11. Oksuz O, "Capturing the onset of PRC2-mediated repressive domain formation", Mol Cell, 70, pp.1149~1162 (2018)
12. Cao R, "SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex", Mol Cell, 15, pp.57~67 (2004)
13. Schmitges FW, "Histone methylation by PRC2 is inhibited by active chromatin marks", Mol Cell, 42, pp.330~341 (2011)
14. Chammas P, "Engaging chromatin : PRC2 structure meets function", Br J Cancer, 122, pp.315~328 (2020)
15. Glancy E, "Structural basis for PRC2 engagement with chromatin", Curr Opin Struct Biol, 67, pp.135~144 (2021)
16. Piunti A, "Catacomb : an endogenous inducible gene that antagonizes H3K27methylation activity of polycomb repressive complex 2via an H3K27M-like mechanism", Sci Adv, 5, pp.eaax2887~ (2019)
17. Ragazzini R, "EZHIP constrains polycomb repressive complex 2 activity in germ cells", Nat Commun, 10, pp.3858~ (2019)
18. Conway E, "A family of vertebrate-specific polycombs encoded by the LCOR", LCORL genes balance PRC2 subtype activities, 2018, pp.70, 408~421
19. Liefke R, "EPOP interacts with elongin BC and USP7 to modulate the chromatin landscape", Mol Cell, 64, pp.659~672 (2016)
20. Beringer M, "EPOP functionally links elongin and polycomb in pluripotent stem cells", Mol Cell, 64, pp.645~658 (2016)
21. Højfeldt JW, "Non-core subunits of the PRC2 complex are collectively required for its target-site specificity", Mol Cell, 76, pp.423~436 (2019)
22. Laugesen A, "Molecular mechanisms directing PRC2 recruitment and H3K27 methylation", Mol Cell, 74, pp.8~18 (2019)
23. Lee CH, "Distinct stimulatory mechanisms regulate the catalytic activity of polycomb repressive complex 2", Mol Cell, 70, pp.435~448 (2018)
24. Son J, "Nucleosome-binding activities within JARID2 and EZH1regulate the function of PRC2 on chromatin", Genes Dev, 27, pp.2663~2677 (2013)
25. Margueron R, "Ezh1 and Ezh2maintain repressive chromatin through different mechanisms", Mol Cell, 32, pp.503~518 (2008)
26. Grau D, "Structures of monomeric and dimeric PRC2 : EZH1 reveal flexible modules involved in chromatin compaction", Nat Commun, 12, pp.714~ (2021)
27. Yuan W, "Dense chromatin activates polycomb repressive complex 2 to regulate H3lysine 27 methylation", Science, 337, pp.971~975 (2012)
28. Bratkowski M, "An evolutionarily conserved structural platform for PRC2 inhibition by a class of Ezh2 inhibitors", Sci Rep, 8, pp.9092~ (2018)
29. Bracken AP, "EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer", EMBO J, 22, pp.5323~5335 (2003)
30. Von Schimmelmann M, "Polycomb repressive complex 2(PRC2)silences genes responsible for neurodegeneration HHS public access", Nat Neurosci, 19, pp.1321~1330 (2016)
31. Shen X, "EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency", Mol Cell, 32, pp.491~502 (2008)
32. Lavarone E, "Dissecting the role of H3K27 acetylation and methylation in PRC2mediated control of cellular identity", Nat Commun, 10, pp.1~16 (2019)
33. Jadhav U, "Replicational dilution of H3K27me3 in mammalian cells and the role of poised promoters", Mol Cell, 78, pp.141~151 (2020)
34. He A, "Polycomb repressive complex 2 regulates normal development of the mouse heart", Circ Res, 110, pp.406~415 (2012)
35. Ezhkova E, "Ezh2orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells", Cell, 136, pp.1122~1135 (2009)
36. Ezhkova E, "EZH1 and EZH2 cogovern histone H3K27trimethylation and are essential for hair follicle homeostasis and wound repair", Genes Dev, 25, pp.485~498 (2011)
37. Hidalgo I, "Ezh1is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest", Cell Stem Cell, 11, pp.649~662 (2012)
38. von Schimmelmann M, "Polycomb repressive complex 2(PRC2)silences genes responsible for neurodegeneration", Nat Neurosci, 2, pp.1~14 (2016)
39. Vo LT, "Regulation of embryonic haematopoietic multipotency by EZH1", Nature, 553, pp.506~510 (2018)
40. Ai S, "Divergent requirements for EZH1 in heart development versus regeneration", Circ Res, 121, pp.106~112 (2017)
41. Hoy SM, "Tazemetostat : first approval", Drugs, 80, pp.513~521 (2020)
42. Chen Z, "Expression of EZH2 is associated with poor outcome in colorectal cancer", Oncol Lett, 15, pp.2953~2961 (2018)
43. Huet S, "EZH2 alterations in follicular lymphoma : biological and clinical correlations", Blood Cancer J, 7, pp.e555~ (2017)
44. Varambally S, "The polycomb group protein EZH2 is involved in progression of prostate cancer", Nature, 419, pp.624~629 (2002)
45. Zingg D, "The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors", Nat Commun, 6, pp.6051~ (2015)
46. Takata K, "Pathology of follicular lymphoma", J Clin Exp Hematop, 54, pp.3~9 (2014)
47. Bödör C, "EZH2 mutations are frequent and represent an early event in follicular lymphoma", Blood, 122, pp.3165~3168 (2013)
48. Yap DB, "Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation", Blood, 117, pp.2451~2459 (2011)
49. McCabe MT, "Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3on lysine 27(H3K27)", Proc Natl Acad Sci, 109, pp.2989~2994 (2012)
50. Ott HM, "A687V EZH2 is a driver of histone H3 lysine 27(H3K27)hypertrimethylation", Mol Cancer Ther, 13, pp.3062~3073 (2014)
51. Souroullas GP, "An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation", Nat Med, 22, pp.632~640 (2016)
52. Becker PB, "Nucleosome remodeling and epigenetics", Cold Spring Harb Perspect Biol, 5, pp.a017905~ (2013)
53. Euskirchen G, "SWI", SNF chromatin-remodeling factors : multiscale analyses and diverse functions, 2012, pp.287, 30897~30905
54. Kadoch C, "Dynamics of BAF-Polycomb complex opposition on heterochromatin in normal and oncogenic states", Nat Genet, 49, pp.213~222 (2017)
55. Zhang W, "The BAF and PRC2 complex subunits dpf2 and eed antagonistically converge on Tbx3 to control ESC differentiation", Cell Stem Cell, 24, pp.138~152 (2019)
56. Schuettengruber B, "Genome regulation by polycomb and trithorax : 70 years and counting", Cell, 171, pp.34~57 (2017)
57. Wilson BG, "Epigenetic antagonism between polycomb and SWI", SNF complexes during oncogenic transformation, 2010, pp.18, 316~328
58. Mittal P, "The SWI", SNF complex in cancer-biology, biomarkers and therapy, 2020, pp.17, 435~448
59. Weber CM, "mSWI", SNF promotes polycomb repression both directly and through genome-wide redistribution, 2021, pp.28, 501~511
60. Calebiro D, "Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas", J Clin Invest, 126, pp.3383~3388 (2016)
61. 송영신, "Genomic Characterization of Differentiated Thyroid Carcinoma", Endocrinology and Metabolism, 34(1), pp.1~10 (2019), 대한내분비학회[DOI]
62. Jung CK, "Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors", Hum Pathol, 81, pp.9~17 (2018)
63. Poepsel S, "Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes", Nat Struct Mol, 25, pp.154~162 (2018)

관련 논문AI추천