본문 바로가기
KERD
논문KCI 등재

Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류화학

초록

Breast cancer has become the most common cancer amongwomen worldwide. Among breast cancers, metastatic breastcancer is associated with the highest mortality rate. Twist1,one of the epithelial-mesenchymal transition-regulating transcriptionfactors, is known to promote the intravasation ofbreast cancer cells into metastatic sites. Therefore, targetingTwist1 to develop anti-cancer drugs might be a valuable strategy. In this study, LY-290181 dose-dependently inhibited migration,invasion, and multicellular tumor spheroid invasion inbreast cancer cell lines. These anti-cancer effects of LY-290181were mediated through the down-regulation of Twist1 proteinlevels. LY-290181 inhibited extracellular signal-regulated kinaseand c-Jun N-terminal kinase signaling pathways. Therefore, ourfindings suggest that LY-290181 may serve as a basis for futureresearch and development of an anti-cancer agent targetingmetastatic cancers.

Abstract

Breast cancer has become the most common cancer amongwomen worldwide. Among breast cancers, metastatic breastcancer is associated with the highest mortality rate. Twist1,one of the epithelial-mesenchymal transition-regulating transcriptionfactors, is known to promote the intravasation ofbreast cancer cells into metastatic sites. Therefore, targetingTwist1 to develop anti-cancer drugs might be a valuable strategy. In this study, LY-290181 dose-dependently inhibited migration,invasion, and multicellular tumor spheroid invasion inbreast cancer cell lines. These anti-cancer effects of LY-290181were mediated through the down-regulation of Twist1 proteinlevels. LY-290181 inhibited extracellular signal-regulated kinaseand c-Jun N-terminal kinase signaling pathways. Therefore, ourfindings suggest that LY-290181 may serve as a basis for futureresearch and development of an anti-cancer agent targetingmetastatic cancers.

참고문헌 (32)

  1. Bray F, "Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries", CA Cancer J Clin, 68, pp.394~424 (2018)
  2. Besic N, "Surgical treatment of breast cancer in patients aged 80 years or older-how much is enough?", BMC Cancer, 14, pp.1~7 (2014)
  3. Pagani O, "International guidelines for management of metastatic breast cancer : can metastatic breast cancer be cured?", J Natl Cancer Inst, 102, pp.456~463 (2010)
  4. Grant CM, "Epithelial mesenchymal transition(EMT)in prostate growth and tumor progression", Transl Androl, 2, pp.202~ (2013)
  5. Ribatti D, "Epithelialmesenchymal transition in cancer : a historical overview", Transl Oncol, 13, pp.100773~ (2020)
  6. Škovierová H, "Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis", Int J Mol Med, 41, pp.1187~1200 (2018)
  7. Moustakas A, "Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression", Cancer Sci, 98, pp.1512~1520 (2007)
  8. Gonzalez DM, "Signaling mechanisms of the epithelial-mesenchymal transition", Sci Signal, 7, pp.re8~ (2014)
  9. Jiang W, "Expression and clinical significance of MAPK and EGFR in triple‑negative breast cancer", Oncol Lett, 19, pp.1842~1848 (2020)
  10. Liu W, "Roles of AKT signal in breast cancer", Front Biosci, 12, pp.4011~4019 (2007)
  11. Zhao Z, "Multiple biological functions of Twist1 in various cancers", Oncotarget, 8, pp.20380~ (2017)
  12. Zhu QQ, "The role of TWIST1 in epithelial-mesenchymal transition and cancers", Tumor Biol, 37, pp.185~197 (2016)
  13. Riaz M, "High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptorpositive human breast cancer and is co-expressed with stromal as well as ECM related genes", Breast Cancer Res, 14, pp.1~15 (2012)
  14. Watson MA, "Isolation and molecular profiling of bone marrow micrometastases identifies TWIST1 as a marker of early tumor relapse in breast cancer patients", Clin Cancer Res, 13, pp.5001~5009 (2007)
  15. Wiernicki TR, "Inhibition of vascular smooth muscle cell proliferation and arterial intimal thickening by a novel antiproliferative naphthopyran", J Pharmacol Exp Ther, 278, pp.1452~1459 (1996)
  16. Wood DL, "Inhibition of mitosis and microtubule function through direct tubulin binding by a novel antiproliferative naphthopyran LY290181", Mol Pharmacol, 52, pp.437~444 (1997)
  17. Panda D, "Suppression of microtubule dynamics by LY290181 : a potential mechanism for its antiproliferative action", J Biol Chem, 272, pp.7681~7687 (1997)
  18. Schmitt F, "New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents", Eur J Med Chem, 163, pp.160~168 (2019)
  19. Sun Y, "Inhibitory effect of emodin on migration, invasion and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo", Oncol Rep, 33, pp.338~346 (2015)
  20. Victorasso Jardim-Perassi B, "Melatonin regulates angiogenic factors under hypoxia in breast cancer cell lines", Anticancer Agents Med Chem, 16, pp.347~358 (2016)
  21. Costa EC, "3D tumor spheroids : an overview on the tools and techniques used for their analysis", Biotechnol Adv, 34, pp.1427~1441 (2016)
  22. Cho SB, "Expression of E-and N-cadherin and clinicopathology in hepatocellular carcinoma", Pathol Int, 58, pp.635~642 (2008)
  23. Kang E, "The posttranslational regulation of epithelial-mesenchymal transitioninducing transcription factors in cancer metastasis", Int J Mol Sci, 22, pp.3591~ (2021)
  24. Seyfried TN, "On the origin of cancer metastasis", Crit Rev Oncog, 18, pp.43~73 (2013)
  25. Rossi L, "Impact of adjuvant chemotherapy on breast cancer survival : a real-world population", PLoS One, 10, pp.e0132853~ (2015)
  26. Kang Y, "Epithelial-mesenchymal transitions : twist in development and metastasis", Cell, 118, pp.277~279 (2004)
  27. Yin L, "Triple-negative breast cancer molecular subtyping and treatment progress", Breast Cancer Res, 22, pp.1~13 (2020)
  28. Kciuk M, "Metastasis and MAPK Pathways", Int J Mol Sci, 23, pp.3847~ (2022)
  29. Santen RJ, "The role of mitogen-activated protein(MAP)kinase in breast cancer", J Steroid Biochem Mol Biol, 80, pp.239~256 (2002)
  30. Shin I, "H-Ras-specific activation of Rac-MKK3", 6-p38 pathway : its critical role in invasion and migration of breast epithelial cells, 2005, pp.280, 14675~14683
  31. Gui T, "The roles of mitogen-activated protein kinase pathways in TGF-β-induced epithelial-mesenchymal transition", J Signal Transduct, 2012, pp.289243~ (2012)
  32. Hong J, "Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness", Cancer Res, 71, pp.3980~3990 (2011)

관련 논문AI추천

Inhibition of p90RSK activation sensitizes triple-negative breast cancer cells to cisplatin by inhibiting proliferation, migration and EMT강건욱, 명창선, 진유진, 허경선, Diem Thi Ngoc Huynh생화학분자생물학회 · BMB Reports2019 · 제52권 제12호Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung CancerAkiko Murakami, Fariz Nurwidya, Fumiyuki Takahashi, Kazuhisa Takahashi대한암학회 · Cancer Research and Treatment2012 · 제44권 제3호Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis김선경, 김정은, 김지현, 김태용, 김태유, 남현진, 민아름, 박소정, 방영주, 송상현, 양예원, 오도연, 이경훈, 이동순, 임경옥, 임석아, 임지민, 한세원, David Hangauer, Johnson Yiu-Nam Lau대한암학회 · Cancer Research and Treatment2017 · 제49권 제3호Lysophosphatidic Acid-Induced TWIST1 and Slug Expression in Oral Cancer Cell Invasion조경화한국치위생과학회 · 치위생과학회지2017 · 제17권 제5호Dexamethasone Inhibits TGF-!1–Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61김영미, 신동복, 조문제, 한상훈, Manh Tin Ho, Ngoc Thuy Bui대한암학회 · Cancer Research and Treatment2016 · 제48권 제3호Beta-Catenin Downregulation Contributes to Epidermal Growth Factor-induced Migration and Invasion of MDAMB231 Cells권아랑, 박현정, 백정화대한구강생물학회 · International Journal of Oral Biology2018 · 제43권 제3호

이 간행물의 다른 논문 (6건)